Patents by Inventor Sara Alajem

Sara Alajem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11280785
    Abstract: A device and method for use in capturing a substance in a liquid, by feeding the liquid through a capturing device including: a lateral capillary flow matrix and a capturing matrix in fluid communication with the lateral capillary flow matrix so as to produce two lateral flows sufficient to impart transverse oscillations to the lateral flow in the capturing matrix, such oscillations driving the liquid into the interior of the capturing matrix thereby exposing its interior to the liquid.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: March 22, 2022
    Assignee: RealBio Technologies Ltd.
    Inventors: Avraham Reinhartz, Sara Alajem
  • Patent number: 10598572
    Abstract: A device for performing lateral capillary flow may comprise a housing having a proximal end and a distal end, said housing comprising an interior defined between a lower base portion and an upper portion coupled to the lower base portion, wherein the interior includes a region sized and shaped to receive a capillary flow matrix. A reservoir may be located in the upper portion of the housing proximate the proximal end of the housing, the reservoir having an inlet accessible from an exterior of the housing and an outlet in flow communication with an interior of the housing at a location above the region. The device may further comprise a support system disposed in the interior of the housing, the support system comprising a surface positioned in the region sized and shaped to receive a capillary flow matrix and in alignment with the outlet of the reservoir, the surface being configured to receive and support a capillary flow matrix received in the region.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: March 24, 2020
    Assignee: REALBIO TECHNOLOGIES, LTD.
    Inventors: Ari Gargir, Eugene Semenov, Avraham Reinhartz, Sara Alajem
  • Patent number: 10335783
    Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: July 2, 2019
    Assignee: REALBIO TECHNOLOGIES, LTD.
    Inventors: Sara Alajem, Avraham Reinhartz
  • Publication number: 20180231543
    Abstract: A device and method for use in capturing a substance in a liquid, by feeding the liquid through a capturing device including: a lateral capillary flow matrix and a capturing matrix in fluid communication with the lateral capillary flow matrix so as to produce two lateral flows sufficient to impart transverse oscillations to the lateral flow in the capturing matrix, such oscillations driving the liquid into the interior of the capturing matrix thereby exposing its interior to the liquid.
    Type: Application
    Filed: April 16, 2018
    Publication date: August 16, 2018
    Applicant: RealBio Technologies Ltd.
    Inventors: Avraham Reinhartz, Sara Alajem
  • Patent number: 9952211
    Abstract: A capturing device (20) and method for use in capturing a substance in a liquid, by feeding the liquid through a capturing device (20) including: a lateral capillary flow matrix (13) and a capturing matrix (26) in fluid communication with the lateral capillary flow matrix (13) such as to produce a lateral capillary flow in the capturing matrix having a lower velocity than that in the lateral capillary flow matrix. This produces by the Bernoulli effect, a lower pressure with respect to the two lateral flows sufficient to impart transverse oscillations to the lateral flow in the capturing matrix, such oscillations driving the liquid into the interior of the capturing matrix thereby exposing its interior, rather than merely a surface thereof, to the liquid. In the described preferred embodiments, the capturing device is a biological assay device, and each substance in the liquid to be captured in the capture zone of the capturing matrix is a biological substance.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: April 24, 2018
    Assignee: RealBio Technologies Ltd.
    Inventors: Avraham Reinhartz, Sara Alajem
  • Publication number: 20180045620
    Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath capillary flow matrix and a plurality of reservoirs each in fluid communication with the capillary flow matrix. The device includes one or more pressure delivery systems configured to urge capillary flow matrix toward a portion of the housing in which it resides, such that a substantially uniform pressure is applied over a portion of the capillary flow matrix.
    Type: Application
    Filed: July 25, 2017
    Publication date: February 15, 2018
    Applicant: REALBIO TECHNOLOGIES, LTD.
    Inventors: Ari GARGIR, Eugene SEMENOV, Avraham REINHARTZ, Sara ALAJEM
  • Patent number: 9726581
    Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath capillary flow matrix and a plurality of reservoirs each in fluid communication with the capillary flow matrix. The device includes one or more pressure delivery systems configured to urge capillary flow matrix toward a portion of the housing in which it resides, such that a substantially uniform pressure is applied over a portion of the capillary flow matrix.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: August 8, 2017
    Assignee: RealBio Technologies Ltd.
    Inventors: Ari Gargir, Eugene Semenov, Avraham Reinhartz, Sara Alajem
  • Publication number: 20160038935
    Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.
    Type: Application
    Filed: July 13, 2015
    Publication date: February 11, 2016
    Inventors: SARA ALAJEM, AVRAHAM REINHARTZ
  • Patent number: 9101927
    Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: August 11, 2015
    Assignee: RealBio Technologies Ltd.
    Inventors: Sara Alajem, Avraham Reinhartz
  • Publication number: 20140294697
    Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath capillary flow matrix and a plurality of reservoirs each in fluid communication with the capillary flow matrix. The device includes one or more pressure delivery systems configured to urge capillary flow matrix toward a portion of the housing in which it resides, such that a substantially uniform pressure is applied over a portion of the capillary flow matrix.
    Type: Application
    Filed: February 10, 2014
    Publication date: October 2, 2014
    Applicant: Life Technologies Israel, Ltd.
    Inventors: Ari GARGIR, Eugene Semenov, Avraham Reinhartz, Sara Alajem
  • Publication number: 20140248389
    Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.
    Type: Application
    Filed: July 10, 2013
    Publication date: September 4, 2014
    Applicant: RealBio Technologies, Ltd.
    Inventors: Sara Alajem, Avraham Reinhartz
  • Patent number: 8507260
    Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/ matrix interface, allowing accurate sequential draining of liquid from the reservoirs.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: August 13, 2013
    Assignee: Realbio Technologies, Ltd.
    Inventors: Sara Alajem, Avraham Reinhartz
  • Publication number: 20110189792
    Abstract: A capturing device (20) and method for use in capturing a substance in a liquid, by feeding the liquid through a capturing device (20) including: a lateral capillary flow matrix (13) and a capturing matrix (26) in fluid communication with the lateral capillary flow matrix (13) such as to produce a lateral capillary flow in the capturing matrix having a lower velocity than that in the lateral capillary flow matrix. This produces by the Bernoulli effect, a lower pressure with respect to the two lateral flows sufficient to impart transverse oscillations to the lateral flow in the capturing matrix, such oscillations driving the liquid into the interior of the capturing matrix thereby exposing its interior, rather than merely a surface thereof, to the liquid. In the described preferred embodiments, the capturing device is a biological assay device, and each substance in the liquid to be captured in the capture zone of the capturing matrix is a biological substance.
    Type: Application
    Filed: June 29, 2009
    Publication date: August 4, 2011
    Applicant: RealBio Technologies Ltd.
    Inventors: Avraham Reinhartz, Sara Alajem
  • Publication number: 20100239459
    Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.
    Type: Application
    Filed: June 2, 2010
    Publication date: September 23, 2010
    Inventors: Sara Alajem, Avraham Reinhartz
  • Publication number: 20080145835
    Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.
    Type: Application
    Filed: January 31, 2006
    Publication date: June 19, 2008
    Applicant: RealBio Technologies LTd
    Inventors: Sara Alajem, Avraham Reinhartz
  • Patent number: 6887662
    Abstract: Oligonucleotides useful in the detection of a nucleic acid target sequence in a sample.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: May 3, 2005
    Assignee: Diasorin srl
    Inventors: Sara Alajem, Avraham Reinhartz, Michal Waksman
  • Publication number: 20040142369
    Abstract: Oligonucoleotides useful in the detection of a nucleic acid target sequence in a sample.
    Type: Application
    Filed: December 29, 2003
    Publication date: July 22, 2004
    Inventors: Sara Alajem, Avraham Reinhartz, Michal Waksman
  • Patent number: 5807751
    Abstract: Apparatus for detection one or more analyte in a fluid sample. The apparatus includes one or more fluid including the fluid sample to be tested for the analyte(s) and one or more vessels for holding the fluid(s). The vessel includes a base at a first end, side walls extending generally perpendicularly from the base to a second end, an opening in the vessel defined by the side walls and the second end and a central axis extending from the center of the base to the center of vessel opening. The apparatus further includes a single matrix sheet including at least one capture site for capturing a specific analyte which is inserted in vessel and spaced from the central axis opposite the side walls and at least one apparatus for detection of a captured specific analyte.
    Type: Grant
    Filed: May 23, 1996
    Date of Patent: September 15, 1998
    Assignee: Gamida Sense Diagnostics Ltd.
    Inventors: Sara Alajem, Menachem Ritterband, Avraham Reinhartz
  • Patent number: 5698395
    Abstract: This disclosure describes an apparatus for separation and detection of target molecules in a liquid sample containing the target molecules and non-target molecules comprising at least one absorption area, a bibulous carrier defining a first liquid transport path in fluid contact with at least one absorption area including at least one reaction area upstream of the at least one absorption area wherein the reaction area includes a capture reagent and a sample area upstream of the reaction area wherein the liquid sample when applied to sample area is transported by capillary action past the reaction area where at least a portion of the target molecules may be bound to the capture reagent to permit detection of the target molecules. The liquid sample is then transported by capillary action on to the absorption area.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: December 16, 1997
    Inventors: Menachem Ritterband, Sara Alajem, Michal Schrift, Ileana Rusu, Avraham Reinhartz