Patents by Inventor Sara Alajem
Sara Alajem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11280785Abstract: A device and method for use in capturing a substance in a liquid, by feeding the liquid through a capturing device including: a lateral capillary flow matrix and a capturing matrix in fluid communication with the lateral capillary flow matrix so as to produce two lateral flows sufficient to impart transverse oscillations to the lateral flow in the capturing matrix, such oscillations driving the liquid into the interior of the capturing matrix thereby exposing its interior to the liquid.Type: GrantFiled: April 16, 2018Date of Patent: March 22, 2022Assignee: RealBio Technologies Ltd.Inventors: Avraham Reinhartz, Sara Alajem
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Patent number: 10598572Abstract: A device for performing lateral capillary flow may comprise a housing having a proximal end and a distal end, said housing comprising an interior defined between a lower base portion and an upper portion coupled to the lower base portion, wherein the interior includes a region sized and shaped to receive a capillary flow matrix. A reservoir may be located in the upper portion of the housing proximate the proximal end of the housing, the reservoir having an inlet accessible from an exterior of the housing and an outlet in flow communication with an interior of the housing at a location above the region. The device may further comprise a support system disposed in the interior of the housing, the support system comprising a surface positioned in the region sized and shaped to receive a capillary flow matrix and in alignment with the outlet of the reservoir, the surface being configured to receive and support a capillary flow matrix received in the region.Type: GrantFiled: July 25, 2017Date of Patent: March 24, 2020Assignee: REALBIO TECHNOLOGIES, LTD.Inventors: Ari Gargir, Eugene Semenov, Avraham Reinhartz, Sara Alajem
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Patent number: 10335783Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.Type: GrantFiled: July 13, 2015Date of Patent: July 2, 2019Assignee: REALBIO TECHNOLOGIES, LTD.Inventors: Sara Alajem, Avraham Reinhartz
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Publication number: 20180231543Abstract: A device and method for use in capturing a substance in a liquid, by feeding the liquid through a capturing device including: a lateral capillary flow matrix and a capturing matrix in fluid communication with the lateral capillary flow matrix so as to produce two lateral flows sufficient to impart transverse oscillations to the lateral flow in the capturing matrix, such oscillations driving the liquid into the interior of the capturing matrix thereby exposing its interior to the liquid.Type: ApplicationFiled: April 16, 2018Publication date: August 16, 2018Applicant: RealBio Technologies Ltd.Inventors: Avraham Reinhartz, Sara Alajem
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Patent number: 9952211Abstract: A capturing device (20) and method for use in capturing a substance in a liquid, by feeding the liquid through a capturing device (20) including: a lateral capillary flow matrix (13) and a capturing matrix (26) in fluid communication with the lateral capillary flow matrix (13) such as to produce a lateral capillary flow in the capturing matrix having a lower velocity than that in the lateral capillary flow matrix. This produces by the Bernoulli effect, a lower pressure with respect to the two lateral flows sufficient to impart transverse oscillations to the lateral flow in the capturing matrix, such oscillations driving the liquid into the interior of the capturing matrix thereby exposing its interior, rather than merely a surface thereof, to the liquid. In the described preferred embodiments, the capturing device is a biological assay device, and each substance in the liquid to be captured in the capture zone of the capturing matrix is a biological substance.Type: GrantFiled: June 29, 2009Date of Patent: April 24, 2018Assignee: RealBio Technologies Ltd.Inventors: Avraham Reinhartz, Sara Alajem
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Publication number: 20180045620Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath capillary flow matrix and a plurality of reservoirs each in fluid communication with the capillary flow matrix. The device includes one or more pressure delivery systems configured to urge capillary flow matrix toward a portion of the housing in which it resides, such that a substantially uniform pressure is applied over a portion of the capillary flow matrix.Type: ApplicationFiled: July 25, 2017Publication date: February 15, 2018Applicant: REALBIO TECHNOLOGIES, LTD.Inventors: Ari GARGIR, Eugene SEMENOV, Avraham REINHARTZ, Sara ALAJEM
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Patent number: 9726581Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath capillary flow matrix and a plurality of reservoirs each in fluid communication with the capillary flow matrix. The device includes one or more pressure delivery systems configured to urge capillary flow matrix toward a portion of the housing in which it resides, such that a substantially uniform pressure is applied over a portion of the capillary flow matrix.Type: GrantFiled: February 10, 2014Date of Patent: August 8, 2017Assignee: RealBio Technologies Ltd.Inventors: Ari Gargir, Eugene Semenov, Avraham Reinhartz, Sara Alajem
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Publication number: 20160038935Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.Type: ApplicationFiled: July 13, 2015Publication date: February 11, 2016Inventors: SARA ALAJEM, AVRAHAM REINHARTZ
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Patent number: 9101927Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.Type: GrantFiled: January 31, 2006Date of Patent: August 11, 2015Assignee: RealBio Technologies Ltd.Inventors: Sara Alajem, Avraham Reinhartz
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Publication number: 20140294697Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath capillary flow matrix and a plurality of reservoirs each in fluid communication with the capillary flow matrix. The device includes one or more pressure delivery systems configured to urge capillary flow matrix toward a portion of the housing in which it resides, such that a substantially uniform pressure is applied over a portion of the capillary flow matrix.Type: ApplicationFiled: February 10, 2014Publication date: October 2, 2014Applicant: Life Technologies Israel, Ltd.Inventors: Ari GARGIR, Eugene Semenov, Avraham Reinhartz, Sara Alajem
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Publication number: 20140248389Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.Type: ApplicationFiled: July 10, 2013Publication date: September 4, 2014Applicant: RealBio Technologies, Ltd.Inventors: Sara Alajem, Avraham Reinhartz
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Patent number: 8507260Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/ matrix interface, allowing accurate sequential draining of liquid from the reservoirs.Type: GrantFiled: June 2, 2010Date of Patent: August 13, 2013Assignee: Realbio Technologies, Ltd.Inventors: Sara Alajem, Avraham Reinhartz
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Publication number: 20110189792Abstract: A capturing device (20) and method for use in capturing a substance in a liquid, by feeding the liquid through a capturing device (20) including: a lateral capillary flow matrix (13) and a capturing matrix (26) in fluid communication with the lateral capillary flow matrix (13) such as to produce a lateral capillary flow in the capturing matrix having a lower velocity than that in the lateral capillary flow matrix. This produces by the Bernoulli effect, a lower pressure with respect to the two lateral flows sufficient to impart transverse oscillations to the lateral flow in the capturing matrix, such oscillations driving the liquid into the interior of the capturing matrix thereby exposing its interior, rather than merely a surface thereof, to the liquid. In the described preferred embodiments, the capturing device is a biological assay device, and each substance in the liquid to be captured in the capture zone of the capturing matrix is a biological substance.Type: ApplicationFiled: June 29, 2009Publication date: August 4, 2011Applicant: RealBio Technologies Ltd.Inventors: Avraham Reinhartz, Sara Alajem
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Publication number: 20100239459Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.Type: ApplicationFiled: June 2, 2010Publication date: September 23, 2010Inventors: Sara Alajem, Avraham Reinhartz
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Publication number: 20080145835Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.Type: ApplicationFiled: January 31, 2006Publication date: June 19, 2008Applicant: RealBio Technologies LTdInventors: Sara Alajem, Avraham Reinhartz
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Patent number: 6887662Abstract: Oligonucleotides useful in the detection of a nucleic acid target sequence in a sample.Type: GrantFiled: December 4, 2000Date of Patent: May 3, 2005Assignee: Diasorin srlInventors: Sara Alajem, Avraham Reinhartz, Michal Waksman
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Publication number: 20040142369Abstract: Oligonucoleotides useful in the detection of a nucleic acid target sequence in a sample.Type: ApplicationFiled: December 29, 2003Publication date: July 22, 2004Inventors: Sara Alajem, Avraham Reinhartz, Michal Waksman
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Patent number: 5807751Abstract: Apparatus for detection one or more analyte in a fluid sample. The apparatus includes one or more fluid including the fluid sample to be tested for the analyte(s) and one or more vessels for holding the fluid(s). The vessel includes a base at a first end, side walls extending generally perpendicularly from the base to a second end, an opening in the vessel defined by the side walls and the second end and a central axis extending from the center of the base to the center of vessel opening. The apparatus further includes a single matrix sheet including at least one capture site for capturing a specific analyte which is inserted in vessel and spaced from the central axis opposite the side walls and at least one apparatus for detection of a captured specific analyte.Type: GrantFiled: May 23, 1996Date of Patent: September 15, 1998Assignee: Gamida Sense Diagnostics Ltd.Inventors: Sara Alajem, Menachem Ritterband, Avraham Reinhartz
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Patent number: 5698395Abstract: This disclosure describes an apparatus for separation and detection of target molecules in a liquid sample containing the target molecules and non-target molecules comprising at least one absorption area, a bibulous carrier defining a first liquid transport path in fluid contact with at least one absorption area including at least one reaction area upstream of the at least one absorption area wherein the reaction area includes a capture reagent and a sample area upstream of the reaction area wherein the liquid sample when applied to sample area is transported by capillary action past the reaction area where at least a portion of the target molecules may be bound to the capture reagent to permit detection of the target molecules. The liquid sample is then transported by capillary action on to the absorption area.Type: GrantFiled: August 30, 1994Date of Patent: December 16, 1997Inventors: Menachem Ritterband, Sara Alajem, Michal Schrift, Ileana Rusu, Avraham Reinhartz