Patents by Inventor Sara CHIRAYIL

Sara CHIRAYIL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Zinc sensors for in vivo imaging of beta-cell function by MRI
    Patent number: 11713305
    Abstract: In some aspects, the present disclosure provides gadolinium based sensors which may be used to image zinc ions in vivo. In some embodiments, the compounds show appropriate reactivity with zinc ions while maintaining high relaxivity to achieve improved background relative to other sensors.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: August 1, 2023
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Andre F. Martins, Sara Chirayil, Maria Veronica Clavijo Jordan, A. Dean Sherry
  • Mn(II)-based sensors to detect zinc in vivo with MRI
    Patent number: 11267832
    Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are defined herein. In some aspects, the present disclosure provides methods of preparing imaging agents, compositions thereof, and methods of imaging using said imaging agents or compositions thereof.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: March 8, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Sara Chirayil, Veronica Clavijo Jordan, Andre F. Martins, A. Dean Sherry
  • Gadolinium-based contrast agents for sensitive detection of Znwith MRI
    Patent number: 11097017
    Abstract: In some aspects, the present disclosure provides novel ligands, which may be used to make novel MRI contrast agents for the detection of zinc. In further aspects, by the present disclosure also provides methods of using as imaging agents and compositions thereof.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: August 24, 2021
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Christian Preihs, Jing Yu, Veronica Clavijo Jordan, Yunkou Wu, Khaled Nasr, A. Dean Sherry, Sara Chirayil
  • MN(II)-BASED SENSORS TO DETECT ZINC IN VIVO WITH MRI
    Publication number: 20200123183
    Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are defined herein. In some aspects, the present disclosure provides methods of preparing imaging agents, compositions thereof, and methods of imaging using said imaging agents or compositions thereof.
    Type: Application
    Filed: October 21, 2019
    Publication date: April 23, 2020
    Inventors: Sara CHIRAYIL, Veronica Clavijo JORDAN, Andre F. MARTINS, A. Dean SHERRY
  • GADOLINIUM-BASED CONTRAST AGENTS FOR SENSITIVE DETECTION OF Zn2+ WITH MRI
    Publication number: 20190142977
    Abstract: In some aspects, the present disclosure provides novel ligands, which may be used to make novel MRI contrast agents for the detection of zinc. In further aspects, by the present disclosure also provides methods of using as imaging agents and compositions thereof.
    Type: Application
    Filed: January 14, 2019
    Publication date: May 16, 2019
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Christian PREIHS, Jing YU, Veronica Clavijo JORDAN, Yunkou WU, Khaled NASR, A. Dean SHERRY, Sara CHIRAYIL
  • Gadolinium-based contrast agents for sensitive detection of Znwith MRI
    Patent number: 10207013
    Abstract: In some aspects, the present disclosure provides novel ligands, which may be used to make novel MRI contrast agents for the detection of zinc. In further aspects, by the present disclosure also provides methods of using as imaging agents and compositions thereof.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: February 19, 2019
    Assignee: The Board of Regents of the University of Texas Systems
    Inventors: Christian Preihs, Jing Yu, Veronica Clavijo Jordan, Yunkou Wu, Khaled Nasr, A. Dean Sherry, Sara Chirayil
  • ZINC SENSORS FOR IN VIVO IMAGING OF BETA-CELL FUNCTION BY MRI
    Publication number: 20190031640
    Abstract: In some aspects, the present disclosure provides gadolinium based sensors which may be used to image zinc ions in vivo. In some embodiments, the compounds show appropriate reactivity with zinc ions while maintaining high relaxivity to achieve improved background relative to other sensors.
    Type: Application
    Filed: July 3, 2018
    Publication date: January 31, 2019
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Andre F. MARTINS, Sara CHIRAYIL, Maria Veroncia Clavijo JORDAN, A. Dean SHERRY
  • NEW GADOLINIUM-BASED CONTRAST AGENTS FOR SENSITIVE DETECTION OF Zn2+ WITH MRI
    Publication number: 20170106103
    Abstract: In some aspects, the present disclosure provides novel ligands, which may be used to make novel MRI contrast agents for the detection of zinc. In further aspects, by the present disclosure also provides methods of using as imaging agents and compositions thereof.
    Type: Application
    Filed: March 11, 2015
    Publication date: April 20, 2017
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Christian PREIHS, Jing YU, Veronica Clavijo JORDAN, Yunkou WU, Khaled NASR, A. Dean SHERRY, Sara CHIRAYIL