Abstract: The disclosure deals with methodology and involved or associated systems for using infrared technology to detect tissue damage below the skin. Pressure and shear stress can damage the microvascular structure below the skin, which is not visible to the naked eye. Infrared thermography is a non-invasive mechanism to measure skin temperature via thermal radiation. Changes (restrictions) in blood flow below the skin can result in microvascular damage to the tissue, and directly impact skin temperature, which can be detected by infrared thermography. Infrared thermography can detect these changes at the site of tissue damage. This disclosure uses affordable infrared thermography to detect changes in temperature related to blood flow alterations, supported with AI. Using serial images, AI can detect an emerging DFU (Diabetic Foot Ulcer) in DM (Diabetes Mellitus) patients through deviations in skin temperature.