Patents by Inventor Sara E. Heisel
Sara E. Heisel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11008580Abstract: This invention provides molecular constructs and methods for the temporally specific control of gene expression in plants or in plant pests or pathogens. More specifically, this invention provides plant miRNA genes having novel circadian expression patterns that are useful for designing recombinant DNA constructs for temporally specific expression of at least one gene. Also provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention.Type: GrantFiled: April 20, 2018Date of Patent: May 18, 2021Assignee: MONSANTO TECHNOLOGY LLCInventors: Edwards M. Allen, Sara E. Heisel, Sergey Ivashuta, Elysia K. Krieger, Jennifer Lutke, Robert J. Meister, Yuanji Zhang
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Patent number: 10793869Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: GrantFiled: June 29, 2017Date of Patent: October 6, 2020Assignee: MONSANTO TECHNOLOGY LLCInventors: Edwards M. Allen, Larry A Gilbertson, Sara E. Heisel, Shihshieh Huang, Elysia K. Krieger, Thomas M. Malvar
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Patent number: 10435686Abstract: This invention discloses novel microRNAs and their precursors, and recombinant DNA constructs including such novel miRNAs, miRNA precursors, miRNA promoters, and miRNA recognition sites corresponding to the miRNAs. Included are novel miRNA and miRNA precursors that exhibit nutrient-responsive expression. Also disclosed are miRNA decoy sequences. Further provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention and methods of controlling gene expression using recombinant DNA constructs of this invention.Type: GrantFiled: December 11, 2014Date of Patent: October 8, 2019Assignee: MONSANTO TECHNOLOGY LLCInventors: Edwards M. Allen, Barry S. Goldman, Liang Guo, Sara E. Heisel, Shihshieh Huang, Sergey I. Ivashuta, David K. Kovalic, Elysia K. Krieger, James K. Roberts, Yuanji Zhang
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Patent number: 10301623Abstract: This invention discloses recombinant DNA constructs encoding phased small RNAs useful in regulating expression of one or more genes of interest. Also disclosed by this invention are transgenic plant cells, plants, and seeds containing a recombinant DNA construct of this invention.Type: GrantFiled: February 24, 2016Date of Patent: May 28, 2019Assignee: Monsanto Technology LLCInventors: Edwards Allen, Liang Guo, Sara E. Heisel, Sergey I. Ivashuta, Yuanji Zhang
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Publication number: 20180237791Abstract: This invention provides molecular constructs and methods for the temporally specific control of gene expression in plants or in plant pests or pathogens. More specifically, this invention provides plant miRNA genes having novel circadian expression patterns that are useful for designing recombinant DNA constructs for temporally specific expression of at least one gene. Also provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention.Type: ApplicationFiled: April 20, 2018Publication date: August 23, 2018Inventors: Edwards M. ALLEN, Sara E. HEISEL, Sergey IVASHUTA, Elysia K. KRIEGER, Jennifer LUTKE, Robert J. MEISTER, Yuanji ZHANG
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Patent number: 9976152Abstract: This invention provides molecular constructs and methods for the temporally specific control of gene expression in plants or in plant pests or pathogens. More specifically, this invention provides plant miRNA genes having novel circadian expression patterns that are useful for designing recombinant DNA constructs for temporally specific expression of at least one gene. Also provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention.Type: GrantFiled: March 9, 2016Date of Patent: May 22, 2018Assignee: MONSANTO TECHNOLOGY LLCInventors: Edwards M. Allen, Sara E. Heisel, Sergey Ivashuta, Elysia K. Krieger, Jennifer Lutke, Robert J. Meister, Yuanji Zhang
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Publication number: 20180002713Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: June 29, 2017Publication date: January 4, 2018Inventors: Edwards M. ALLEN, Larry A. GILBERTSON, Sara E. HEISEL, Shihshieh HUANG, Elysia K. KRIEGER, Thomas M. MALVAR
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Patent number: 9708620Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: GrantFiled: December 24, 2014Date of Patent: July 18, 2017Assignee: Monsanto Technology LLCInventors: Edwards M. Allen, Larry A. Gilbertson, Sara E. Heisel, Shihshieh Huang, Elysia K. Krieger, Thomas M. Malvar
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Publication number: 20160186194Abstract: This invention provides molecular constructs and methods for the temporally specific control of gene expression in plants or in plant pests or pathogens. More specifically, this invention provides plant miRNA genes having novel circadian expression patterns that are useful for designing recombinant DNA constructs for temporally specific expression of at least one gene. Also provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention.Type: ApplicationFiled: March 9, 2016Publication date: June 30, 2016Applicant: Monsanto Technology LLCInventors: Edwards M. Allen, Sara E. Heisel, Sergey Ivashuta, Elysia K. Krieger, Jennifer Lutke, Robert J. Meister, Yuanji Zhang
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Publication number: 20160168569Abstract: This invention discloses recombinant DNA constructs encoding phased small RNAs useful in regulating expression of one or more genes of interest. Also disclosed by this invention are transgenic plant cells, plants, and seeds containing a recombinant DNA construct of this invention.Type: ApplicationFiled: February 24, 2016Publication date: June 16, 2016Applicant: Monsanto Technology LLCInventors: Edwards Allen, Liang Guo, Sara E. Heisel, Sergey I. Ivashuta, Yuanji Zhang
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Patent number: 9315819Abstract: This invention provides molecular constructs and methods for the temporally specific control of gene expression in plants or in plant pests or pathogens. More specifically, this invention provides plant miRNA genes having novel circadian expression patterns that are useful for designing recombinant DNA constructs for temporally specific expression of at least one gene. Also provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention.Type: GrantFiled: February 27, 2014Date of Patent: April 19, 2016Assignee: Monsanto Technology LLCInventors: Edwards M. Allen, Sara E. Heisel, Sergey Ivashuta, Elysia K. Krieger, Jennifer Lutke, Robert J. Meister, Yuanji Zhang
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Patent number: 9309512Abstract: This invention discloses recombinant DNA constructs encoding phased small RNAs useful in regulating expression of one or more genes of interest. Also disclosed by this invention are transgenic plant cells, plants, and seeds containing a recombinant DNA construct of this invention.Type: GrantFiled: February 25, 2013Date of Patent: April 12, 2016Assignee: Monsanto Technology LLCInventors: Edwards Allen, Liang Guo, Sara E. Heisel, Sergey I. Ivashuta, Yuanji Zhang
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Patent number: 9212370Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: GrantFiled: March 18, 2010Date of Patent: December 15, 2015Assignee: Monsanto Technology LLCInventors: Edwards M. Allen, Larry A. Gilbertson, Sara E. Heisel, Shihshieh Huang, Elysia K. Krieger, Thomas M. Malvar
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Publication number: 20150184179Abstract: The present invention provides molecular constructs and methods for use thereof, including constructs including heterologous miRNA recognition sites, constructs for gene suppression including a gene suppression element embedded within an intron flanked on one or on both sides by non-protein-coding sequence, constructs containing engineered miRNA or miRNA precursors, and constructs for suppression of production of mature microRNA in a cell. Also provided are transgenic plant cells, plants, and seeds containing such constructs, and methods for their use. The invention further provides transgenic plant cells, plants, and seeds containing recombinant DNA for the ligand-controlled expression of a target sequence, which may be endogenous or exogenous. Also disclosed are novel miRNAs and miRNA precursors from crop plants including maize and soy.Type: ApplicationFiled: December 24, 2014Publication date: July 2, 2015Applicant: MONSANTO TECHNOLOGY LLCInventors: Edwards M. Allen, Larry A. Gilbertson, Sara E. Heisel, Shihshieh Huang, Elysia K. Krieger, Thomas M. Malvar
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Publication number: 20150166993Abstract: This invention discloses novel microRNAs and their precursors, and recombinant DNA constructs including such novel miRNAs, miRNA precursors, miRNA promoters, and miRNA recognition sites corresponding to the miRNAs. Included are novel miRNA and miRNA precursors that exhibit nutrient-responsive expression. Also disclosed are miRNA decoy sequences. Further provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention and methods of controlling gene expression using recombinant DNA constructs of this invention.Type: ApplicationFiled: December 11, 2014Publication date: June 18, 2015Applicant: MONSANTO TECHNOLOGY LLCInventors: Edwards M. Allen, Barry S. Goldman, Liang Guo, Sara E. Heisel, Shihshieh Huang, Sergey I. Ivashuta, David K. Kovalic, Elysia K. Krieger, James K. Roberts, Yuanji Zhang
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Patent number: 8946511Abstract: This invention discloses novel microRNAs and their precursors, and recombinant DNA constructs including such novel miRNAs, miRNA precursors, miRNA promoters, and miRNA recognition sites corresponding to the miRNAs. Included are novel miRNA and miRNA precursors that exhibit nutrient-responsive expression. Also disclosed are miRNA decoy sequences. Further provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention and methods of controlling gene expression using recombinant DNA constructs of this invention.Type: GrantFiled: October 12, 2007Date of Patent: February 3, 2015Assignee: Monsanto Technology LLCInventors: Edwards Allen, Barry S. Goldman, Liang Guo, Sara E. Heisel, Shihshieh Huang, Sergey I. Ivashuta, David K. Kovalik, Elysia K. Krieger, James K. Roberts, Yuanji Zhang
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Publication number: 20140317780Abstract: This invention provides molecular constructs and methods for the temporally specific control of gene expression in plants or in plant pests or pathogens. More specifically, this invention provides plant miRNA genes having novel circadian expression patterns that are useful for designing recombinant DNA constructs for temporally specific expression of at least one gene. Also provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention.Type: ApplicationFiled: February 27, 2014Publication date: October 23, 2014Applicant: Monsanto Technology LLCInventors: Edwards M. Allen, Sara E. Heisel, Sergey Ivashuta, Elysia K. Krieger, Jennifer Lutke, Robert J. Meister, Yuanji Zhang
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Patent number: 8697949Abstract: This invention provides molecular constructs and methods for the temporally specific control of gene expression in plants or in plant pests or pathogens. More specifically, this invention provides plant miRNA genes having novel circadian expression patterns that are useful for designing recombinant DNA constructs for temporally specific expression of at least one gene. Also provided are non-natural transgenic plant cells, plants, and seeds containing in their genome a recombinant DNA construct of this invention.Type: GrantFiled: June 26, 2008Date of Patent: April 15, 2014Assignee: Monsanto Technology LLCInventors: Edwards Allen, Sara E. Heisel, Sergey Ivashuta, Elysia Krieger, Jennifer Lutke, Robert J. Meister, Yuanji Zhang
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Publication number: 20130232644Abstract: This invention discloses recombinant DNA constructs encoding phased small RNAs useful in regulating expression of one or more genes of interest.Type: ApplicationFiled: February 25, 2013Publication date: September 5, 2013Applicant: MONSANTO TECHNOLOGY LLCInventors: Edwards Allen, Liang Guo, Sara E. Heisel, Sergey I. Ivashuta, Yuanji Zhang
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Patent number: 8404928Abstract: This invention discloses recombinant DNA constructs encoding phased small RNAs useful in regulating expression of one or more genes of interest. Also disclosed by this invention are transgenic plant cells, plants, and seeds containing a recombinant DNA construct of this invention.Type: GrantFiled: August 31, 2007Date of Patent: March 26, 2013Assignee: Monsanto Technology LLCInventors: Edwards Allen, Liang Guo, Sara E. Heisel, Sergey I. Ivashuta, Yuanji Zhang