Patents by Inventor Sara Ginsburg

Sara Ginsburg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4235906
    Abstract: Intermediate-duration reversible neuromuscular blocking agents of the formula (I) ##STR1## where B and C are preferably para or may be meta and are each ##STR2## where W is CH.sub.2 or most preferably CH.dbd.CH R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are each hydrogen or lower alkoxy of 1 to 4 carbon atoms and preferably methoxy, Y is lower alkyl of 1 to 4 carbon atoms and preferably methyl, Z is hydrogen, lower alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, benzyl, or ##STR3## where ALKYL has 1 to 4 carbon atoms preferably where the O-ALKYL is at the 2, 3, 4 or 5 positions such as 4-methoxy benzyl and is most preferably 3,4-dimethoxy benzyl or 3, 4, 5-trimethoxybenzyl, n is 2, 3 or 4, most preferably 2 or 3 provided that at least one of R.sub.1 to R.sub.4 is lower alkoxy and most preferably where R.sub.1 and R.sub.4 is hydrogen and R.sub.2 and R.sub.3 are methoxy and X is a pharmaceutically acceptable anion.
    Type: Grant
    Filed: January 31, 1979
    Date of Patent: November 25, 1980
    Assignee: Massachusetts General Hospital
    Inventors: John J. Savarese, Richard J. Kitz, Sara Ginsburg
  • Patent number: 4192877
    Abstract: Short acting reversible neuromuscular blocking agents of the formula (I) ##STR1## where B and C is preferably meta or maybe para ##STR2## where m is 2, 3 or 4 and is preferably 2,R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are the same or different and are hydrogen or lower alkoxy of 1 to 4 carbon atomsY is lower alkyl of 1 to 4 carbon atomsn is 2, 3 or 4, most preferably 3, provided that at least one of R.sub.1 to R.sub.4 and one of R.sub.5 to R.sub.7 is lower alkoxy and X is a pharmaceutically acceptable anion. These neuromuscular blocking agents of formula I are useful upon administration to a patient in providing muscular relaxation in the patient during surgery and are normally intravenously administered in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: July 3, 1978
    Date of Patent: March 11, 1980
    Assignee: Massachusetts General Hospital
    Inventors: John J. Savarese, Richard J. Kitz, Sara Ginsburg