Abstract: The invention relates to an apparatus and method of detecting and quantifying the number of circulating tumour cells (CTCs) and/or tumour cells (TCs) from a liquid biopsy by using a hyperoxic environment and incubation with a fluorophore-labelled metabolic indicator (fluorophore-labelled 2-D-glucose derivative) and microfluidic chips.

Abstract: The present invention relates to a device and method for the preparation of platelet rich plasma, and to the plasma obtained by employing said device and method. The method comprises evaporating and dialysing plasma with the device of the invention to provide a plasma enriched in platelets and non-platelet biomolecules. The plasma thus obtained shows improved regenerative properties with respect to other plasma preparations.

Abstract: A method and a system for detection of presence or absence of analytes in fluids, the method comprising the steps of: a) contacting a fluid sample and a plurality of nanoparticles, the nanoparticles being functionalized with a selective ligand, the contact of the fluid sample with the nanoparticles being under conditions such that, the nanoparticles aggregate selectively on surface of their target analyte, forming a nanoparticle-analyte complex, the aggregation promoting the concentration of the nanoparticles on the surface of the target analyte; b) subjecting a fluid mixture of the fluid sample and the plurality of nanoparticles to SERS; c) measuring at least a SERS signal associated with the fluid mixture; d) spectrally analyzing the at least one SERS signal of step c); e) recognizing at least one defined SERS spectrum of the nanoparticle-analyte complex, through a SERS signal enhanced by the at least one narrow inter-nanoparticle gap.

Abstract: The invention relates to an apparatus and method of detecting and quantifying the number of circulating tumour cells (CTCs) and/or tumour cells (TCs) from a liquid biopsy by using a hyperoxic environment and incubation with a fluorophore-labelled metabolic indicator (fluorophore-labelled 2-D-glucose derivative) and microfluidic chips.

Abstract: A method and a system for detection of presence or absence of analytes in fluids, the method comprising the steps of: a) contacting a fluid sample and a plurality of nanoparticles, the nanoparticles being functionalized with a selective ligand, the contact of the fluid sample with the nanoparticles being under conditions such that, the nanoparticles aggregate selectively on surface of their target analyte, forming a nanoparticle-analyte complex, the aggregation promoting the concentration of the nanoparticles on the surface of the target analyte; b) subjecting a fluid mixture of the fluid sample and the plurality of nanoparticles to SERS; c) measuring at least a SERS signal associated with the fluid mixture; d) spectrally analysing the at least one SERS signal of step c); e) recognizing at least one defined SERS spectrum of the nanoparticle-analyte complex, through a SERS signal enhanced by the at least one narrow inter-nanoparticle gap.