Abstract: The present invention relates to the treatment of T-cell acute lymphoblastic leukemia (T-ALLs) by means of immunotherapy with a monoclonal antibody which recognizes the pre-TCR receptor which, due to its presence in all phases of T-ALL pre-TCR+ development, can also be used as a leukemia-initiating cell (LIC) biomarker and as a therapeutic target useful for monitoring minimal residual disease and identifying compounds inhibiting the disease.

Abstract: A switch, in particular a grounding switch, is for quickly establishing a ground connection and for extinguishing an arc fault for a switching system. The grounding switch includes at least one fixed contact having a first cable feed, a moving contact, a contact guide having a second cable feed, and a mechanical energy store. In the opened state, an insulating distance between the fixed contact and the moving contact, is filled with insulation liquid, at least in part. The switch further includes a triggering device and a locking mechanism.

Abstract: The present invention relates to silane-crosslinking curable compositions encompassing a polymer P having at least two terminal groups of the following formulas (I) and (II) -Am-K1—SiR1XY (I), -Am-K2—SiR2XY (II), and/or two polymers P1 and P2, polymer P1 having terminal groups of the following formula (I) -Am-K1—SiR1XY (I), and polymer P2 having terminal groups of the following formula (II) -Am-K2—SiR2XY (II), in which A denotes a divalent bonding group, K1, K2, mutually independently, denote a divalent aliphatic hydrocarbon group that has a main chain of 1 to 6 carbon atoms, the hydrocarbon groups K1, K2 being different, X, Y mutually independently denote a hydroxy group or a hydrolyzable group, R1, R2 mutually independently denote a hydrocarbon residue having 1 to 20 carbon atoms, and m assumes the values 0 or 1.

Abstract: A method for producing a silylated polyurethane including the steps: (A) converting (i) at least polyol compound having a molecular weight of 4,000-30,000 g/mol and at least one monofunctional compound relative to isocyanates and (ii) at least one diisocyanate at a stoichiometric excess of the sum of the polyol compound(s) and monofunctional compound relative to the diisocyanate compound(s), whereby a hydroxyl-terminated polyurethane prepolymer is formed; and (B) converting the polyurethane prepolymer and one or more isocyanate silane(s) of the formula (I): OCN—R—Si—(R1)m(-OR2)3-m, where m is 0, 1 or 2, each R2 is an alkyl radical having 1 to 4 carbon atoms, each R1 is an alkyl radical having 1 to 4 carbon atoms, and R is a difunctional organic group. Also compounds comprising the silylated polyurethane that can be so produced, and the use thereof as an adhesive and sealant or coating composition.

Abstract: The invention relates to silane cross-linking curable compositions, comprising a polymer P with at least two terminal groups of the following formulae (I) and (II) -Am-K1-SiXYZ (1), -Am-K2-SiXYZ (II), and/or two polymers P1 and P2, the polymer P1 having terminal groups of the following formula (I) -Am-K1-SiXYZ (I), and the polymer P2 having terminal groups of the following formula (II) -Am-K2-SiXYZ (II). In said formulae, A represents a bivalent binding group K1 and K2 independently of one another represent a bivalent aliphatic hydrocarbon group with a main chain of between 1 and 6 carbon atoms, the hydrocarbon groups K1, K2 being different, X, Y and Z independently of one another represent a hydroxy group of a hydrolysable group and m stands for 0 or 1.

Abstract: The invention relates to silane cross-linking curable compositions, comprising a polymer P with at least two terminal groups of the following formulae (I) and (II) -Am-K1—SiXYZ (I), -Am-K2—SiXYZ (II), and/or two polymers P1 and P2, the polymer P1 having terminal groups of the following formula (I) -Am-K1—SiXYZ (I), and the polymer P2 having terminal groups of the following formula (II) -Am-K2—SiXYZ (II). In said formulae, A represents a bivalent binding group K1 and K2 independently of one another represent a bivalent aliphatic hydrocarbon group with a main chain of between 1 and 6 carbon atoms, the hydrocarbon groups K1, K2 being different, X, Y and Z independently of one another represent a hydroxy group of a hydrolysable group and m stands for 0 or 1.

Abstract: The invention relates to a silylated polyurethane that is manufactured by reacting at least one polyether compound having an OH number per DIN 53783 between 3 and 20 mg KOH/g, made up of at least two polyoxyalkylene blocks A and B, the number of carbon atoms in the alkylene units of blocks A and B differing by at least 1, with one or more isocyanatosilanes of formula (I): OCN—R—Si—(R1)m(—OR2)3-m, in which m is 0, 1, or 2, each R2 is an alkyl residue having 1 to 4 carbon atoms, each R1 is an alkyl residue having 1 to 4 carbon atoms, and R is a difunctional organic group, in order to cap the hydroxyl groups of the prepolymer with the isocyanatosilane, thereby forming a silylated polyurethane that comprises alkoxysilyl groups as reactive end groups. The silylated polyurethanes that are described are suitable for the manufacture of adhesive, sealant, or coating-agent preparations having good mechanical properties.

Abstract: The invention relates to a method for producing cross-linkable formulations. In a first step of the method, at least one ?,?-difunctional organic polymer of formula (1) X-A-X (1) is converted into organyloxysilyl-terminated polymers P1, using organofunctional silanes of formula (2) Y—R—Si—(R1)m(—OR2)3m (2), in the presence of catalysts (A) selected from the group consisting of potassium, iron, indium, zinc, bismuth and copper compounds.

Abstract: A method for producing a silylated polyurethane including the steps: (A) converting (i) at least polyol compound having a molecular weight of 4,000-30,000 g/mol and at least one monofunctional compound relative to isocyanates and (ii) at least one diisocyanate at a stoichiometric excess of the sum of the polyol compound(s) and monofunctional compound relative to the diisocyanate compound(s), whereby a hydroxyl-terminated polyurethane prepolymer is formed; and (B) converting the polyurethane prepolymer and one or more isocyanate silane(s) of the formula (I): OCN—R—Si—(R1)m(-OR2)3-m, where m is 0, 1 or 2, each R2 is an alkyl radical having 1 to 4 carbon atoms, each R1 is an alkyl radical having 1 to 4 carbon atoms, and R is a difunctional organic group. Also compounds comprising the silylated polyurethane that can be so produced, and the use thereof as an adhesive and sealant or coating composition.

Abstract: The invention relates to silane cross-linking curable compositions, comprising a polymer P with at least two terminal groups of the following formulae (I) and (II) -Am-K1—SiXYZ (I), -Am-K2—SiXYZ (II), and/or two polymers P1 and P2, the polymer P1 having terminal groups of the following formula (I) -Am-K1—SiXYZ (I), and the polymer P2 having terminal groups of the following formula (II) -Am-K2—SiXYZ (II). In said formulae, A represents a bivalent binding group K1 and K2 independently of one another represent a bivalent aliphatic hydrocarbon group with a main chain of between 1 and 6 carbon atoms, the hydrocarbon groups K1, K2 being different, X, Y and Z independently of one another represent a hydroxy group of a hydrolysable group and m stands for 0 or 1.

Abstract: The present invention relates to silane-crosslinking curable compositions encompassing a polymer P having at least two terminal groups of the following formulas (I) and (II) -Am-K1—SiR1XY (I), -Am-K2—SiR2XY (II), and/or two polymers P1 and P2, polymer P1 having terminal groups of the following formula (I) -Am-K1—SiR1XY (I), and polymer P2 having terminal groups of the following formula (II) -Am-K2—SiR2XY (II), in which A denotes a divalent bonding group, K1, K2, mutually independently, denote a divalent aliphatic hydrocarbon group that has a main chain of 1 to 6 carbon atoms, the hydrocarbon groups K1, K2 being different, X, Y mutually independently denote a hydroxy group or a hydrolyzable group, R1, R2 mutually independently denote a hydrocarbon residue having 1 to 20 carbon atoms, and m assumes the values 0 or 1.