Patents by Inventor Sara H. Thrall

Sara H. Thrall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for characterizing enzyme inhibitors
    Patent number: 7897330
    Abstract: Methods for characterizing a biochemical reaction and analysis of reaction products by establishing continuously variable concentration gradients of one or more reagents of the biochemical reaction are provided. Methods for determining mechanism of inhibition or activation, potency of inhibition or activation, or both of an enzyme inhibitor or activator, respectively, are also provided. The continuously variable concentration gradients can be established in a microfluidic chip.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: March 1, 2011
    Assignee: AB Sciex, LLC
    Inventors: Mehul Patel, Dawn M. Schmidt, Sara H. Thrall, David G. Tew
  • METHODS FOR CHARACTERIZING BIOLOGICAL MOLECULE MODULATORS
    Publication number: 20090148858
    Abstract: Methods for characterizing a biochemical reaction and analysis of reaction products by establishing continuously variable concentration gradients of one or more reagents of the biochemical reaction are provided. Methods for determining mechanism of inhibition or activation, potency of inhibition or activation, or both of an enzyme inhibitor or activator, respectively, are also provided. The continuously variable concentration gradients can be established in a microfluidic chip.
    Type: Application
    Filed: August 10, 2006
    Publication date: June 11, 2009
    Applicant: EKSIGENT TECHNOLOGIES, LLC
    Inventors: Mehul Patel, Dawn M. Schmidt, Sara H. Thrall, David G. Tew
  • MICROFLUIDIC APPARATUS AND METHOD FOR SAMPLE PREPARATION AND ANALYSIS
    Publication number: 20090053814
    Abstract: The pumps (Pn) are operated to transport individual reagent streams into the chip in a non-pulsatile, laminar flow regime at low flow rates permitting lows grading from 0 to as little as 5 nl/min with a precision of 0.1 nl/min. In the chip (MFC), the reagent streams are merged and the reagents mixed to form a reaction product. The reaction product can be measured at one or more detection points defined in the chip. Concentration gradients are continuously varied by continuously varying the flow rates respectively produced by the pumps according to predetermined flow velocity profiles.
    Type: Application
    Filed: August 10, 2006
    Publication date: February 26, 2009
    Applicant: EKSIGENT TECHNOLOGIES, LLC
    Inventors: Mehul Patel, Daniel M. Hartmann, Joshua T. Nevill, Katya M. Prince, David G. Tew, Sara H. Thrall, Gregory A. Votaw, Hugh C. Crenshaw