Patents by Inventor Sara J. Fernandez

Sara J. Fernandez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MONOCLONAL ANTIBODIES THAT TARGET PATHOLOGICAL ASSEMBLIES OF AMYLOID BETA (ABETA)
    Publication number: 20130330837
    Abstract: Disclosed herein are antibodies that bind with high specificity to soluble oligomers of amyloid ? (Abeta) and methods utilizing such antibodies. The antibodies are able to distinguish between Alzheimer's Disease (AD) and control human brain extracts. The antibodies identify endogenous Abeta oligomers in AD brain slices and also bind to Abeta oligomers on cultured hippocampal cells. The antibodies neutralize endogenous Abeta oligomers and Abeta oligomers produced in solution.
    Type: Application
    Filed: July 16, 2013
    Publication date: December 12, 2013
    Applicants: Acumen Pharmaceuticals, Inc., Northwestern University
    Inventors: Mary P. Lambert, Pauline T. Velasco, Lei Chang, Kirsten L. Viola, Sara J. Fernandez, Pascale N. Lacor, Daliya Khuon, Yuesong Gong, William L. Klein, Grant A. Krafft
  • Monoclonal antibodies that target pathological assemblies of amyloid ? (Abeta)
    Patent number: 8507206
    Abstract: Disclosed herein are antibodies that bind with high specificity to soluble oligomers of amyloid ? (Abeta) and methods of employing those antibodies. The antibodies are able to distinguish between Alzheimer's Disease (AD) and control human brain extracts. The antibodies identify endogenous Abeta oligomers in AD brain slices and also bind to Abeta oligomers on cultured hippocampal cells. The antibodies neutralize endogenous Abeta oligomers and Abeta oligomers produced in solution.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: August 13, 2013
    Assignees: Northwestern University, Acumen Pharmaceuticals, Inc.
    Inventors: Mary P Lambert, Pauline T. Velasco, Lei Chang, Kirsten L. Viola, Sara J. Fernandez, Pascale N. Lacor, Daliya Khuon, Yuesong Gong, William L. Klein, Grant A. Krafft
  • Compositions Comprising Addl Receptors, Related Compositions, and Related Methods
    Publication number: 20080306074
    Abstract: Disclosed and claimed herein are compositions comprising ADDL receptors, related compositions, and related methods. ADDL receptors are typically, but perhaps not exclusively, localized at the post-synaptic density (PSD) of neuronal cells. Related compositions include, but are not limited to, compounds that affect, positively or negatively, ADDL binding to neuronal cells, either via one or more receptors localized at the post-synaptic density (PSD) or otherwise. Related methods include, but are not limited to, procedures to screen for compounds that affect, either positively or negatively, ADDL binding to neuronal cells, either via one or more receptors localized at the post-synaptic density (PSD) or otherwise.
    Type: Application
    Filed: May 16, 2005
    Publication date: December 11, 2008
    Inventors: Pascale N. Lacor, Kirsten L. Viola, Mary P. Lambert, Yeusong Gong, Lei Chang, Pauline T. Velasco, Eileen H. Bigio, Maria C. Buniel, Sara J. Fernandez, Jasna Jerecic, Susan Catalano, Todd Pray, Ray Lowe, Grant A. Krafft, William L. Klein