Patents by Inventor Sara J. Holditch

Sara J. Holditch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and materials for increasing viral vector infectivity
    Patent number: 11207424
    Abstract: This document relates to methods and materials for increasing viral vector infectivity. For example, methods and materials for using spliceosome inhibitors (e.g., U2 snRNP spliceosome inhibitors such as meayamycin B or pladienolide derivative E7107) to increase viral vector (e.g., adeno-associated virus-based vector) infectivity are provided.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: December 28, 2021
    Assignees: Mayo Foundation for Medical Education and Research, University of Pittsburgh—Of the Commonwealth System of Higher Educat
    Inventors: Yasuhiro Ikeda, Claire A. Schreiber, Toshie Sakuma, Sara J. Holditch, Kazunori Koide
  • METHODS AND MATERIALS FOR REDUCING CYSTS AND KIDNEY WEIGHT IN MAMMALS WITH POLYCYSTIC KIDNEY DISEASE
    Publication number: 20170333530
    Abstract: This document provides methods and materials for using natriuretic polypeptides to reduce the generation of kidney cysts, to reduce the number of kidney cysts, to reduce the size of kidney cysts, and/or to reduce the weight of a mammal's kidneys in mammals with polycystic kidney disease. For example, methods and materials for using natriuretic polypeptides (e.g., BNP) and/or nucleic acid encoding natriuretic polypeptides to reduce kidney cystogenesis and to reduce kidney organ to body weight ratios in mammals with mammals with polycystic kidney disease (e.g., autosomal recessive polycystic kidney disease) are provided.
    Type: Application
    Filed: November 5, 2015
    Publication date: November 23, 2017
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Yasuhiro Ikeda, Sara J. Holditch, Alessandro Cataliotti, Vicente E. Torres
  • METHODS AND MATERIALS FOR INCREASING VIRAL VECTOR INFECTIVITY
    Publication number: 20170112946
    Abstract: This document relates to methods and materials for increasing viral vector infectivity. For example, methods and materials for using spliceosome inhibitors (e.g., U2 snRNP spliceosome inhibitors such as meayamycin B or pladienolide derivative E7107) to increase viral vector (e.g., adeno-associated virus-based vector) infectivity are provided.
    Type: Application
    Filed: June 12, 2015
    Publication date: April 27, 2017
    Applicants: Mayo Foundation for Medical Education and Research, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Yasuhiro Ikeda, Claire A. Schreiber, Toshie Sakuma, Sara J. Holditch, Kazunori Koide