Patents by Inventor Sara Keene

Sara Keene has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
    Publication number: 20070066550
    Abstract: The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
    Type: Application
    Filed: March 7, 2005
    Publication date: March 22, 2007
    Inventors: John Diener, Alicia Ferguson, Nobuko Hamaguchi, Sara Keene, H.A. Lagasse, Pooja Sawhney, Kristin Thompson
  • Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics
    Publication number: 20070009907
    Abstract: The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.
    Type: Application
    Filed: April 26, 2005
    Publication date: January 11, 2007
    Inventors: Paula Burmeister, Sharon Cload, John Diener, Anthony Keefe, Sara Keene, Markus Kurz, H.A. Lagasse, Harold Marsh, Pooja Sawhney, Chunhua Wang
  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Publication number: 20060105980
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Application
    Filed: December 22, 2005
    Publication date: May 18, 2006
    Inventors: Claude Benedict, John Diener, David Epstein, Dilara Grate, Sara Keene, Jeffrey Kurz, Markus Kurz, Thomas McCauley, James Rottman, Kristin Thompson, Charles Wilson, Anna Zoltoski
  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Publication number: 20060018871
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Application
    Filed: February 14, 2005
    Publication date: January 26, 2006
    Inventors: Claude Benedict, John Diener, David Epstein, Dilara Grate, Sara Keene, Jeffrey Kurz, Markus Kurz, Thomas McCauley, James Rottman, Kristin Thompson, Charles Wilson, Anna Zoltoski
  • Method for in vitro selection of 2'-substituted nucleic acids
    Publication number: 20050037394
    Abstract: Materials and methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence. The aptamers produced by the methods of the invention have increased stability and half life.
    Type: Application
    Filed: June 21, 2004
    Publication date: February 17, 2005
    Inventors: Anthony Keefe, Charles Wilson, Paula Burmeister, Sara Keene