Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Abstract: A scheduler for ranking-based scheduling of multiple users on a shared communication channel of a serving base station in a wireless communication system comprises a determiner (42), a priority ranker (44), a user selector (46) and a resource allocator (48). The determiner (42) is configured to determine, for each user of a given traffic class, measured bandwidth share ratios with respect to each of a number of other traffic classes. The priority ranker (44) is configured to determine, for each user, a priority rank based on i) achievable bit rate of the user according to reported channel quality, and ii) a quality of service component representing compliance of the measured bandwidth share ratios to corresponding target bandwidth share ratios.

Abstract: A scheduler for ranking-based scheduling of multiple users on a shared communication channel of a serving base station in a wireless communication system comprises a determiner (42), a priority ranker (44), a user selector (46) and a resource allocator (48). The determiner (42) is configured to determine, for each user of a given traffic class, measured bandwidth share ratios with respect to each of a number of other traffic classes. The priority ranker (44) is configured to determine, for each user, a priority rank based on i) achievable bit rate of the user according to reported channel quality, and ii) a quality of service component representing compliance of the measured bandwidth share ratios to corresponding target bandwidth share ratios.