Patents by Inventor Sara Louise Isbell

Sara Louise Isbell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of Thiol Compounds to Treat Neurological Disease
    Publication number: 20230115413
    Abstract: The present disclosure relates, in general, to use of small diffusible thiols in the treatment of neurodegenerative diseases associated with glutamate excitotoxicity, protein aggregation and oxidative stress in the central nervous system, particularly in the brain.
    Type: Application
    Filed: April 1, 2022
    Publication date: April 13, 2023
    Inventors: Todd C. Zankel, Sara Louise Isbell
  • Methods of Treating Excitotoxicity Disorders
    Publication number: 20210113496
    Abstract: The present disclosure relates in general to methods for the treatment of excitotoxicity disorders, using compositions comprising cysteamine or cystamine or salts or derivatives thereof in combination with an agent that inhibits or blocks glutamate/cystine antiporter xc?.
    Type: Application
    Filed: April 25, 2019
    Publication date: April 22, 2021
    Inventors: Todd C. Zankel, Amanda Anne Ko, Sara Louise Isbell
  • Use of Thiol Compounds to Treat Neurological Disease
    Publication number: 20210069129
    Abstract: The present disclosure relates, in general, to use of small diffusible thiols in the treatment of neurodegenerative diseases associated with glutamate excitotoxicity, protein aggregation and oxidative stress in the central nervous system, particularly in the brain.
    Type: Application
    Filed: June 23, 2020
    Publication date: March 11, 2021
    Inventors: Todd C. Zankel, Sara Louise Isbell
  • Fucosidase inhibitors
    Patent number: 10308607
    Abstract: The present disclosure relates, in general, to compounds useful as inhibitors of fucosidase enzymes, and to methods and compositions for the treatment of tumors or cancers, such as liver disorders and liver tumors (e.g., hepatocellular carcinoma), with a compound as disclosed herein.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: June 4, 2019
    Assignee: HORIZON ORPHAN LLC
    Inventors: Todd C. Zankel, Sara Louise Isbell, Amanda Anne Ko
  • FUCOSIDASE INHIBITORS
    Publication number: 20190077756
    Abstract: The present disclosure relates, in general, to compounds useful as inhibitors of fucosidase enzymes, and to methods and compositions for the treatment of tumors or cancers, such as liver disorders and liver tumors (e.g., hepatocellular carcinoma), with a compound as disclosed herein.
    Type: Application
    Filed: March 30, 2018
    Publication date: March 14, 2019
    Applicant: HORIZON ORPHAN LLC
    Inventors: Todd C. Zankel, Sara Louise Isbell, Amanda Anne Ko
  • Use of Thiol Compounds to Treat Neurological Disease
    Publication number: 20190029977
    Abstract: The present disclosure relates, in general, to use of small diffusible thiols in the treatment of neurodegenerative diseases associated with glutamate excitotoxicity, protein aggregation and oxidative stress in the central nervous system, particularly in the brain.
    Type: Application
    Filed: April 24, 2018
    Publication date: January 31, 2019
    Inventors: Todd C. Zankel, Sara Louise Isbell
  • Fucosidase inhibitors
    Patent number: 9951013
    Abstract: The present disclosure relates, in general, to compounds useful as inhibitors of fucosidase enzymes, and to methods and compositions for the treatment of tumors or cancers, such as liver disorders and liver tumors (e.g., hepatocellular carcinoma), with a compound as disclosed herein.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: April 24, 2018
    Assignee: Horizon Orphan LLC
    Inventors: Todd C. Zankel, Sara Louise Isbell, Amanda Anne Ko
  • FUCOSIDASE INHIBITORS
    Publication number: 20170029376
    Abstract: The present disclosure relates, in general, to compounds useful as inhibitors of fucosidase enzymes, and to methods and compositions for the treatment of tumors or cancers, such as liver disorders and liver tumors (e.g., hepatocellular carcinoma), with a compound as disclosed herein.
    Type: Application
    Filed: August 1, 2016
    Publication date: February 2, 2017
    Applicant: RAPTOR PHARMACEUTICALS INC.
    Inventors: Todd C. Zankel, Sara Louise Isbell, Amanda Anne Ko