Abstract: A needle disclosed herein may include an elongate body extending between a proximal end and a distal end with a central longitudinal axis defined by the body, where the distal end includes a single sharp point along the central longitudinal axis and defining a distal end terminus three longitudinal fluted surfaces converging at the distal end terminus; and three longitudinal beveled cutting edges defining borders between the fluted surfaces and converging at the distal end terminus. Needle embodiments may include one or more ports open into and/or proximal of the fluted surfaces and communicating with one or more longitudinal needle lumens.

Abstract: An expandable endoluminal prosthesis may include a graft body and a support structure attached to the graft body. The graft body may include a tubular body of nonwoven electrospun fibers disposed about a longitudinal axis. A first fiber matrix segment may be attached to and extend in a transverse direction along the tubular body. A second fiber matrix segment may be attached to and extend in a longitudinal direction along the tubular body.

Abstract: An occlusion device for placement within a body vessel may include a wire constructed support structure having a covering applied thereto. The covering includes a mixture of PET and ultra-high molecular weight polyethylene (UHMWPE). The covering is applied to the support structure via an electrospinning process to produce a non-woven fiber covering having increase strain capabilities relative to an electrospun PET covering without UHMWPE. The device has a nominal state that is radially expanded and a delivery state that is radially compressed and longitudinally extended for disposal within a low-profile delivery sheath. The covering increased strain capability allows for the device to have relative large diameter in the nominal state while still being capable of low-profile delivery. This occlusion device can provide faster occlusive capability when deployed and does not rely on delayed embolization. The covering extends across the vessel upon deployment to provide instant occlusion.

Abstract: A needle disclosed herein may include an elongate body extending between a proximal end and a distal end with a central longitudinal axis defined by the body, where the distal end includes a single sharp point along the central longitudinal axis and defining a distal end terminus three longitudinal fluted surfaces converging at the distal end terminus; and three longitudinal beveled cutting edges defining borders between the fluted surfaces and converging at the distal end terminus. Needle embodiments may include one or more ports open into and/or proximal of the fluted surfaces and communicating with one or more longitudinal needle lumens.

Abstract: A needle disclosed herein may include an elongate body extending between a proximal end and a distal end with a central longitudinal axis defined by the body, where the distal end includes a single sharp point along the central longitudinal axis and defining a distal end terminus three longitudinal fluted surfaces converging at the distal end terminus; and three longitudinal beveled cutting edges defining borders between the fluted surfaces and converging at the distal end terminus. Needle embodiments may include one or more ports open into and/or proximal of the fluted surfaces and communicating with one or more longitudinal needle lumens.

Abstract: An endoluminal prosthesis and systems and methods for making the prosthesis are provided. In one example, a patterned graft material for a prosthesis includes a network of electrospun fibers. The network of electrospun fibers may include a plurality of continuous electrospun fibers. The fibers may be collected on a collector plate using an electrospinning process to form the network of fibers. The patterned graft material also may include a plurality of openings in the network of electrospun fibers. The plurality of openings may be arranged in a pattern. The network of electrospun fibers may include a plurality of edges, each surrounding a corresponding one of the plurality of openings. Each of the plurality of edges may include at least one electrospun fiber of the network of electrospun fibers. A majority of the electrospun fibers of the plurality of edges may be continuous at the edges.

Abstract: An occlusion device for placement within a body vessel may include a wire constructed support structure having a covering applied thereto. The covering includes a mixture of PET and ultra-high molecular weight polyethylene (UHMWPE). The covering is applied to the support structure via an electrospinning process to produce a non-woven fiber covering having increase strain capabilities relative to an electrospun PET covering without UHMWPE. The device has a nominal state that is radially expanded and a delivery state that is radially compressed and longitudinally extended for disposal within a low-profile delivery sheath. The covering increased strain capability allows for the device to have relative large diameter in the nominal state while still being capable of low-profile delivery. This occlusion device can provide faster occlusive capability when deployed and does not rely on delayed embolization. The covering extends across the vessel upon deployment to provide instant occlusion.

Abstract: A stent is provided with braided filaments. First and second filaments are braided with each other and extend spirally around the stent wall in opposite directions. One or more third filaments are braided with the first filaments and extends spirally around the stent wall only in the direction of the second filaments. The third filament is stiffer than the first and second filaments, and there are fewer third filaments than the first and second filaments.

Abstract: A needle disclosed herein may include an elongate body extending between a proximal end and a distal end with a central longitudinal axis defined by the body, where the distal end includes a single sharp point along the central longitudinal axis and defining a distal end terminus three longitudinal fluted surfaces converging at the distal end terminus; and three longitudinal beveled cutting edges defining borders between the fluted surfaces and converging at the distal end terminus. Needle embodiments may include one or more ports open into and/or proximal of the fluted surfaces and communicating with one or more longitudinal needle lumens.

Abstract: An expandable endoluminal prosthesis may include a graft body and a support structure attached to the graft body. The graft body may include a tubular body of nonwoven electrospun fibers disposed about a longitudinal axis. A first fiber matrix segment may be attached to and extend in a transverse direction along the tubular body. A second fiber matrix segment may be attached to and extend in a longitudinal direction along the tubular body.

Abstract: An endoluminal prosthesis for placement within a body vessel may include a tubular support structure including a proximal end segment, a distal end segment, an intermediate segment positioned between the proximal end segment and the distal end segment, a lumen extending longitudinally within the support structure, a luminal surface, and an abluminal surface opposite the luminal surface. The prosthesis may include a first layer of nonwoven electrospun fibers positioned on the luminal surface of the support structure. The prosthesis may include a second layer of nonwoven electrospun fibers positioned on the abluminal surface of the support structure. At least one of the proximal end segment or the distal end segment of the support structure may be encapsulated within a covering including the first layer of nonwoven electrospun fibers and the second layer of nonwoven electrospun fibers. The intermediate segment of the support structure may be unencapsulated within the covering.

Abstract: An endoluminal prosthesis and systems and methods for making the prosthesis are provided. In one example, a patterned graft material for a prosthesis includes a network of electrospun fibers. The network of electrospun fibers may include a plurality of continuous electrospun fibers. The fibers may be collected on a collector plate using an electrospinning process to form the network of fibers. The patterned graft material also may include a plurality of openings in the network of electrospun fibers. The plurality of openings may be arranged in a pattern. The network of electrospun fibers may include a plurality of edges, each surrounding a corresponding one of the plurality of openings. Each of the plurality of edges may include at least one electrospun fiber of the network of electrospun fibers. A majority of the electrospun fibers of the plurality of edges may be continuous at the edges.