Abstract: A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I): (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable drug selected from prostaglandins, ?-blockers and mixtures thereof; L is a linker group group; and at least one co-monomer of Formula III III J represents a linking functional group, n is 2 to 8, preferably 3 to 8; Y comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched Ci to

Abstract: A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R5 is selected from hydrogen and C1 to C6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D.

Abstract: Controlling notifications based on an importance of the notifications to users is described. A service provider can receive notifications. The service provider can determine an order for sending the notifications based partly on priority levels assigned to the notifications and positions associated with presentations of the notifications. The service provider can send a first notification to at least one device in a first period of time. The service provider can determine that sending a second notification causes a conflict with a presentation policy. Accordingly, the service provider can determine a second period of time subsequent to the first period of time to send the second notification to the at least one device based partly on a lapse of a predetermined amount of time and/or an occurrence of an event, and can send the second notification to the at least one device in the second period of time.

Abstract: The present invention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety selected from quinolones, NSAIDs and mixtures thereof. The present invention also relates to methods for preparing the polymer conjugates using click cycloaddition chemical reactions, to monomer-bioactive agent conjugates suitable for preparing the polymer conjugates, and to pharmaceutical products comprising the polymer conjugates for the post-surgical care to treat or prevent infections, provide analgesia and treat inflammation.

Abstract: Controlling notifications based on an importance of the notifications to users is described. A service provider can receive notifications. The service provider can determine an order for sending the notifications based partly on priority levels assigned to the notifications and positions associated with presentations of the notifications. The service provider can send a first notification to at least one device in a first period of time. The service provider can determine that sending a second notification causes a conflict with a presentation policy. Accordingly, the service provider can determine a second period of time subsequent to the first period of time to send the second notification to the at least one device based partly on a lapse of a predetermined amount of time and/or an occurrence of an event, and can send the second notification to the at least one device in the second period of time.

Abstract: A method for moderating an electronic message includes intercepting the electronic message at a server computing device, and evaluating content of the electronic message at the server computing device to determine if the electronic message is required to enter a moderation workflow prior to delivering the electronic message to at least one recipient. The method also includes sending an approval request message from the server computing device to at least one moderator device, receiving a first moderation decision message at the server computing device from the at least one moderator, sending an update message from the server computing device to the at least one moderator to update the approval request message to include one or more properties of the first moderation decision, and removing the approval request message from the moderation workflow.

Abstract: A set of workflows are provided for supporting proper user notifications after an action is taken by the user in conjunction with an asynchronous communication service. Timing and/or type of the notifications or an action to be taken by the service is determined based on one or more of a nature of the user action that failed, a time elapsed since the action was taken, multi-action dependencies, device types, and similar characteristics enhancing user experience and reducing confusion.

Abstract: A method for moderating an electronic message includes intercepting the electronic message at a server computing device, and evaluating content of the electronic message at the server computing device to determine if the electronic message is required to enter a moderation workflow prior to delivering the electronic message to at least one recipient. The method also includes sending an approval request message from the server computing device to at least one moderator device, receiving a first moderation decision message at the server computing device from the at least one moderator, sending an update message from the server computing device to the at least one moderator to update the approval request message to include one or more properties of the first moderation decision, and removing the approval request message from the moderation workflow.