Abstract: A bra includes an adjustable body strap that has a rear portion with first and second coupling features disposed on a single side thereof, and first and second support straps that are respectively coupled at one end to the rear portion of the body strap. Each of the first and second support straps includes a fastening material, first and second fabric materials, and a flexibly resilient material. The first fabric, the flexibly resilient material, the second fabric, and the fastening material are integrally formed to define a laminated support strap of each of the first and second support straps.

Abstract: The present disclosure relates to immunomodulatory compositions that selectively activate TLR7, comprising an RNA ligand and a pharmaceutically acceptable carrier, as well as to in vitro and therapeutic uses of such immunomodulatory compositions.

Abstract: Provided are methods and compositions for the heterologous expression of a payload (e.g., DNA, RNA, protein) of interest in a target cell (e.g., cancer cell). In some cases payload delivery results in expression (e.g., by a cancer cell in vivo) of a secreted immune signal such as a cytokine, a plasma membrane-tethered affinity marker (thus resulting in an induced immune response), or a cytotoxic protein such as an apoptosis inducer (e.g., by a cancer cell in vivo). Payloads are delivered with a delivery vehicle and in some cases the delivery vehicle is a nanoparticle. In some cases a subject nanoparticle includes a targeting ligand for targeted delivery to a specific cell type/tissue type (e.g., a cancerous tissue/cell). In some embodiments, payload delivery is “personalized” in the sense that the delivery vehicle and/or payload can be designed based on patient-specific information.

Abstract: A bra includes first and second cups that are laterally spaced-apart. The first and second cups each have upper edges. First and second support straps are selectively coupled to the upper edges of the first and second cups. The first and second support straps each include a first end that has a first coupling feature and a body portion that has a second coupling feature. The second coupling feature is a reciprocal coupling feature to the first coupling feature. Each of the first and second support straps also includes a second end that has a retention feature, first and second fabrics, a pliable material, and a fastening material. The fastening material includes the first and second coupling features. The first fabric, the pliable material, the second fabric, and the fastening material are integrally formed to define a laminated support strap of each of the first and second support straps.

Abstract: A bra includes an adjustable body strap that has a rear portion with first and second coupling features disposed on a single side thereof, and first and second support straps that are respectively coupled at one end to the rear portion of the body strap. Each of the first and second support straps includes a fastening material, first and second fabric materials, and a flexibly resilient material. The first fabric, the flexibly resilient material, the second fabric, and the fastening material are integrally formed to define a laminated support strap of each of the first and second support straps.

Abstract: A brassiere and garment system includes a garment having a tubular body portion with an upper edge, wherein a rear portion of the upper edge downwardly drapes between first and second sides of the tubular body portion. First and second fasteners each include an anchor portion defining a mounting aperture and a coupling portion defining a receiving aperture disposed above the mounting aperture. The brassiere includes first and second support straps having free ends that are configured to be received through the receiving apertures of the first and second fasteners, respectively, such that the garment is suspended from the adjustable first and second straps of the brassiere in use.

Abstract: A magnetic fastener includes a female component and a male component. The female component includes a base, a hooded portion spaced from the base and formed opposite thereto, and a peripheral wall connecting the base to the hooded portion. A pocket is formed between the base and the hooded portion. The hooded portion includes a slot formed therein. A portion of the female component is magnetically attractive. The male component includes an insertion portion and a shaft extending from the insertion portion. A portion of the male component is formed by a magnet. The male component is configured to be coupled to the female component when the magnet is magnetically coupled to the portion of the female component that is magnetically attractive, the insertion portion is received within the pocket, and the shaft is received within the slot.

Abstract: A method for monitoring condition of a door on a vehicle, the door includes a first panel, a second panel, a first motor, a second motor, a first striker/latch assembly, and a second striker/latch assembly. The method includes steps of generating status indicators and communicating those indicator to a computer on the vehicle. The computer processes those status indicators to determine action regarding the vehicle.

Abstract: An apparatus for actuating a door on a vehicle, the door including a first panel and a second panel both movable between an open position and a completely closed position. A first motor is operatively connected with the first pane for moving the first panel and a second motor operatively connected with the second panel for moving the second panel. A first striker/latch assembly is disposed adjacent the first panel, and a second striker/latch assembly disposed adjacent the second panel. A computer is electrically connected with the first motor, the second motor, the first striker/latch assembly and the second striker/latch assembly.

Abstract: A magnetic fastener includes a female component and a male component. The female component includes a base, a hooded portion spaced from the base and formed opposite thereto, and a peripheral wall connecting the base to the hooded portion. A pocket is formed between the base and the hooded portion. The hooded portion includes a slot formed therein. A portion of the female component is magnetically attractive. The male component includes an insertion portion and a shaft extending from the insertion portion. A portion of the male component is formed by a magnet. The male component is configured to be coupled to the female component when the magnet is magnetically coupled to the portion of the female component that is magnetically attractive, the insertion portion is received within the pocket, and the shaft is received within the slot.

Abstract: Provided are methods and compositions for genome editing using sticky ends. Subject methods include (a) generating a staggered cut at each of two locations in genomic DNA of a target cell, thus generating two genomic staggered ends; and (b) providing/introducing a linear double stranded donor DNA that has staggered ends (i.e., sticky ends) that match/correspond to the sticky ends of the genomic DNA such that the sticky ends of the donor DNA hybridize with the sticky ends of the genomic DNA and the donor DNA is inserted into the genome. In some cases, the staggered cuts are generated by introducing into a target cell one or more sequence specific nucleases (or one or more nucleic acids encoding the one or more sequence specific nucleases).

Abstract: The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer or inflammatory conditions mediated by autoreactive B cells in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize at least one tumor antigen or B-lineage cell antigen and NKp30 and/or another activating NK receptor. In some aspects, multispecific antigen-binding constructs are provided that recognize at least two tumor antigens or two antigens expressed by B-lineage cells, NKp30, and another activating NK receptor. The multispecific antigen-binding constructs and methods disclosed herein can be used for the treatment of cancer, even a cancer characterized by a CD16 deficient microenvironment and/or characterized by target cells (e.g., cancer cells) having a low level of expression of the tumor antigen.

Abstract: The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer or inflammatory conditions mediated by autoreactive B cells in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize at least one tumor antigen or B-lineage cell antigen and NKp30 and/or another activating NK receptor. In some aspects, multispecific antigen-binding constructs are provided that recognize at least two tumor antigens or two antigens expressed by B-lineage cells, NKp30, and another activating NK receptor. The multispecific antigen-binding constructs and methods disclosed herein can be used for the treatment of cancer, even a cancer characterized by a CD16 deficient microenvironment and/or characterized by target cells (e.g., cancer cells) having a low level of expression of the tumor antigen.

Abstract: A magnetic fastener including a female component and a male component, each of the female component and the male component coupled to a magnet. When assembled, the magnet of the male component and the magnet of the female component are magnetically engaged and cooperate to militate against undesired disengagement of the magnetic fastener.

Abstract: Provided are minimal hammerhead ribozymes and catalytic strands thereof. Aspects of the present disclosure include a catalytic strand of a minimal hammerhead ribozyme, the catalytic strand including a catalytic core region, a stem I-forming region, a stem II region, and a stem III-forming region. The catalytic strand hybridizes to a target strand via the stem I-forming region and the stem III-forming region. A nucleotide (e.g., an adenine, cytosine, or a natural or non-natural nucleotide base having hydrogen bond donor and acceptor functionalities at positions analogous to those of adenine or cytosine) present in a stem II loop base pairs with a nucleotide (e.g., uracil or cytosine) at position 1.7 of the target strand. Also provided are compositions that include the catalytic strands, and methods of using the catalytic strands, e.g., in a variety of different applications, as well as kits that find use in practicing embodiments of the methods.

Abstract: An endoluminal prosthesis for placement within a body vessel may include a tubular support structure including a proximal end segment, a distal end segment, an intermediate segment positioned between the proximal end segment and the distal end segment, a lumen extending longitudinally within the support structure, a luminal surface, and an abluminal surface opposite the luminal surface. The prosthesis may include a first layer of nonwoven electrospun fibers positioned on the luminal surface of the support structure. The prosthesis may include a second layer of nonwoven electrospun fibers positioned on the abluminal surface of the support structure. At least one of the proximal end segment or the distal end segment of the support structure may be encapsulated within a covering including the first layer of nonwoven electrospun fibers and the second layer of nonwoven electrospun fibers. The intermediate segment of the support structure may be unencapsulated within the covering.

Abstract: Methods and system to diagnose central sleep apnea of a patient employ a relatively short test, combining few breathing parameters. The test is short in comparison to commonly used time-consuming and complex multi-parameter sleep studies. The patient uses a positive airway pressure device, and follows breathing cues. The occurrence of a central apnea during the delivery of breathing cues may support a diagnosis of central sleep apnea.

Abstract: A subject is prompted to consciously alter one or more breathing parameters of respiration. To prompt the subject to alter one or more breathing parameters, a pressurized flow of breathable gas is provided to the airway of the subject. One or more gas parameters of the gas in the pressurized flow of breathable gas are adjusted to provide breathing cues to the subject that encourage the subject to consciously adjust respiration such that the one or more breathing parameters are altered. Information is also conveyed to the subject through a user interface that dynamically provides information to the subject about the breathing cues.

Abstract: Provided are minimal hammerhead ribozymes and catalytic strands thereof. Aspects of the present disclosure include a catalytic strand of a minimal hammerhead ribozyme, the catalytic strand including a catalytic core region, a stem I-forming region, a stem II region, and a stem III-forming region. The catalytic strand hybridizes to a target strand via the stem I-forming region and the stem III-forming region. A nucleotide (e.g., an adenine, cytosine, or a natural or non-natural nucleotide base having hydrogen bond donor and acceptor functionalities at positions analogous to those of adenine or cytosine) present in a stem II loop base pairs with a nucleotide (e.g., uracil or cytosine) at position 1.7 of the target strand. Also provided are compositions that include the catalytic strands, and methods of using the catalytic strands, e.g., in a variety of different applications, as well as kits that find use in practicing embodiments of the methods.

Abstract: A wake-to-sleep transition for a subject is detected based on responsiveness to breathing cues provided to the subject. A pressurized flow of breathable gas to the airway of subject having one or more gas parameters that are adjusted to provide breathing cues to the subject. Based on a detected conformance of the respiration of the subject to the breathing cues, a determination is made as to whether the subject is awake or asleep.