Patents by Inventor Sara P. Gaucher

Sara P. Gaucher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targets for therapeutic intervention identified in the mitochondrial proteome
    Publication number: 20040101874
    Abstract: Mitochondrial targets for drug screening assays and for therapeutic intervention in the treatment of diseases associated with altered mitochondrial function are provided. Complete amino acid sequences [SEQ ID NOS:1-3025] of polypeptides that comprise the human heart mitochondrial proteome are provided, using fractionated proteins derived from highly purified mitochondrial preparations, to identify previously unrecognized mitochondrial molecular components.
    Type: Application
    Filed: April 4, 2003
    Publication date: May 27, 2004
    Applicants: MitoKor Inc., The Buck Institute for Age Research
    Inventors: Soumitra S. Ghosh, Eoin D. Fahy, Bing Zhang, Bradford W. Gibson, Steven W. Taylor, Gary M. Glenn, Dale E. Warnock, Sara P. Gaucher
  • Glycosylated polyamines and methods of use therefor
    Patent number: 6531454
    Abstract: Glycosylated polyamines comprising of mono- or oligo-saccharides that are glycosidically linked to an aliphatic polyamine, and pharmaceutically acceptable salts, prodrugs and derivatives thereof are provided. An exemplary glycosylated polyamine has the following structure: Glycosylated polyamines, their pharmaceutically acceptable salts, prodrugs and derivatives are useful, for example, as anticancer compounds for the treatment of a variety of cancers. Methods for synthesis of glycosylated polyamines are disclosed. In addition, metal complexes of glycosylated polyamines, the preparation of such metal complexes, analytical methods using the metal complexes are provided. Methods for detecting equatorial and axial conformation of a group other than hydrogen at the C2 position of a saccharide molecule are also provided. The compounds of the invention can be used as anti-cancer agents (e.g., against breast, ovarian, colon or renal cancers).
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: March 11, 2003
    Assignee: The Regents of the University of California
    Inventors: Julie A. Leary, Sara P. Gaucher, Steven F. Pedersen
  • Glycosylated polyamines
    Patent number: 6420344
    Abstract: Glycosylated polyamines comprising of mono- or oligo-saccharides that are glycosidically linked to an aliphatic polyamine, and pharmaceutically acceptable salts, prodrugs and derivatives thereof are provided. An exemplary glycosylated polyamine has the following structure: Glycosylated polyamines, their pharmaceutically acceptable salts, prodrugs and derivatives are useful, for example, as anticancer compounds for the treatment of a variety of cancers. Methods for synthesis of glycosylated polyamines are disclosed. In addition, metal complexes of glycosylated polyamines, the preparation of such metal complexes, analytical methods using the metal complexes are provided. Methods for detecting equatorial and axial conformation of a group other than hydrogen at the C2 position of a saccharide molecule are also provided.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: July 16, 2002
    Assignee: The Regents of the University of California
    Inventors: Julie A. Leary, Sara P. Gaucher, Steven F. Pedersen