Patents by Inventor Sara Petersen Bjørn

Sara Petersen Bjørn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for extracting quantitative information relating to an influence on a cellular response
    Patent number: 8058008
    Abstract: Cells are genetically modified to express a luminophore, e.g., a modified (F64L, S65T, Y66H) Green Fluorescent Protein (GFP, EGFP) coupled to a component of an intracellular signalling pathway such as a transcription factor, a cGMP- or cAMP-dependent protein kinase, a cyclin-, calmodulin- or phospholipid-dependent or mitogen-activated serine/threonin protein kinase, a tyrosine protein kinase, or a protein phosphatase (e.g. PKA, PKC, Erk, Smad, VASP, actin, p38, Jnk1, PKG, IkappaB, CDK2, Grk5, Zap70, p85, protein-tyrosine phosphatase 1C, Stat5, NFAT, NFkappaB, RhoA, PKB). An influence modulates the intracellular signalling pathway in such a way that the luminophore is being redistributed or translocated with the component in living cells in a manner experimentally determined to be correlated to the degree of the influence.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: November 15, 2011
    Assignee: Fisher Bioimage APS
    Inventors: Ole Thastrup, Sara Petersen Bjørn, Soren Tullin, Kasper Almholt, Kurt Scudder
  • Nucleic acids encoding fluorescent proteins and methods of using the same
    Patent number: 7476518
    Abstract: A GFP with an F64L mutation and E222G mutation is provided. This GFP has a bigger Stokes shift compared to other GFPs making it very suitable for high throughput screening due to a better resolution. This GFP also has an excitation maximum between the yellow GFP and the cyan GFP allowing for clearer band separation when used together with those GFPs. Examples include the sequences in SEQ ID NOs: 3 and 4.
    Type: Grant
    Filed: August 19, 2005
    Date of Patent: January 13, 2009
    Assignee: Fisher BioImage APS
    Inventors: Sara Petersen Bjørn, Len Pagliaro, Ole Thastrup
  • Fluorescent proteins
    Patent number: 7314915
    Abstract: The present invention relates to novel variants of the fluorescent protein GFP having improved fluorescence properties.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: January 1, 2008
    Assignee: Fisher BioImage APS
    Inventors: Ole Thastrup, Søren Tullin, Lars Kongsbak Poulsen, Sara Petersen Bjørn
  • Fluorescent proteins
    Patent number: 6818443
    Abstract: The present invention relates to novel variants of the fluorescent protein GFP having improved fluorescence properties.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: November 16, 2004
    Assignee: BioImage A/S
    Inventors: Ole Thastrup, Søren Tullin, Lars Kongsbak Poulsen, Sara Petersen Bjørn
  • Method of detecting biologically active substances
    Patent number: 6566083
    Abstract: The present invention relates to a method of detecting biologically active substances affecting intracellular processes, an isolated DNA, a vector and a cell for use in the method. More specifically, the present invention provides a method for detecting a biologically active substance that affects intracellular processes mediated through a protein kinase or a second messenger, which comprises incubating a cell with a test substance and measuring any change caused by the test substance in the flourescence of (i) a wild-type or modified green flourescent protein (GFP) having a protein kinase recognition site, (ii) a modified GFP containing a second messenger binding domain, or (iii) a hybrid polypeptide having a wild-type or modified GFP and an attached protein kinase recognition site or a second messenger binding domain.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: May 20, 2003
    Assignee: Novo Nordisk A/S
    Inventors: Ole Thastrup, Søren Tullin, Lars Kongsbak Poulsen, Sara Petersen Bjørn
  • Method for extracting quantitative information relating to an influence on a cellular response
    Patent number: 6518021
    Abstract: Cells are genetically modified to express a luminophore, e.g., a modified (F64L, S65T, Y66H) Green Flourescent Protein (GFP, EGFP) coupled to a component of an intracellular signalling pathway such as a transcription factor, a cGMP- or cAMP-dependent protein kinase, a cyclin-, calmodulin- or phospholipid-dependent or mitogen-activated serine/threonin protein kinase, a tryosine protein kinase, or a protein phosphatase (e.g. PKA, PKC, Erk, Smad, VASP, actin, p38, Jnkl, PKG, IkappaB, CDK2, Grk5, Zap70, p85, protein-tyrosine phosphatase 1C, Stat5, NFAT, NFkappaB, RhoA, PKB). An influence modulates the intracellular signaling pathway in such a way that the luminophore is being redistributed or translocated with the component in living cells in a manner experimentally determined to be correlated to the degree of influence.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: February 11, 2003
    Assignee: BioImage A/S
    Inventors: Ole Thastrup, Sara Petersen Bjørn, Soren Tullin, Kasper Almholt, Kurt Scudder
  • Fluorescent proteins
    Patent number: 6172188
    Abstract: The present invention relates to novel variants of the fluorescent protein GFP having improved fluorescence properties.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: January 9, 2001
    Inventors: Ole Thastrup, Søren Tullin, Lars Kongsbak Poulsen, Sara Petersen Bjørn