Patents by Inventor Sara Peterson Bjørn

Sara Peterson Bjørn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metabolically engineered cells for the production of pinosylvin
    Patent number: 8343739
    Abstract: A genetically engineered micro-organism having an operative metabolic pathway producing cinnamoyl-CoA and producing pinosylvin therefrom by the action of a stilbene synthase is used for pinosylvin production. Said cinnamic acid may be formed from L-phenylalanine by a L-phenylalanine ammonia lyase (PAL) which is one accepting phenylalanine as a substrate and producing cinammic acid therefrom, preferably such that if the PAL also accepts tyrosine as a substrate and forms coumaric acid therefrom, the ratio Km(phenylalanine)/Km(tyrosine) for said PAL is less than 1:1 and if said micro-organism produces a cinammate-4-hydroxylase enzyme (C4H), the ratio Kcat(PAL)/Kcat(C4H) is at least 2:1.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: January 1, 2013
    Assignee: Fluxome Sciences A/S
    Inventors: Michael Katz, Jochen Förster, Helga David, Hans Peter Schmidt, Malin Sendelius, Sara Peterson Bjørn, Thomas Thomasen Durhuus
  • METABOLICALLY ENGINEERED CELLS FOR THE PRODUCTION OF PINOSYLVIN
    Publication number: 20090317881
    Abstract: A genetically engineered micro-organism having an operative metabolic pathway producing cinnamoyl-CoA and producing pinosylvin therefrom by the action of a stilbene synthase is used for pinosylvin production. Said cinnamic acid may be formed from L-phenylalanine by a L-phenylalanine ammonia lyase (PAL) which is one accepting phenylalanine as a substrate and producing cinammic acid therefrom, preferably such that if the PAL also accepts tyrosine as a substrate and forms coumaric acid therefrom, the ratio Km(phenylalanine)/Km(tyrosine) for said PAL is less than 1:1 and if said micro-organism produces a cinammate-4-hydroxylase enzyme (C4H), the ratio Kcat(PAL)/Kcat(C4H) is at least 2:1.
    Type: Application
    Filed: July 19, 2007
    Publication date: December 24, 2009
    Applicant: FLUXOME SCIENCES A/S
    Inventors: Michael Katz, Jochen Förster, Helga David, Hans Peter Schmidt, Malin Sendelius, Sara Peterson Bjørn, Thomas Thomasen Durhuus