Patents by Inventor Sara Thorslund
Sara Thorslund has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11427851Abstract: A fluidic device has a culture chamber configured to house a 3D culture matrix comprising a culture of microorganisms. A concentration gradient of a test substance is established over the 3D culture matrix by providing respective fluid flows at different end portions of the culture chamber and comprising different concentrations of the test substance. The response of the microorganisms to the test substance is determined based on the position of a border zone in the 3D culture matrix.Type: GrantFiled: October 22, 2019Date of Patent: August 30, 2022Assignee: GRADIENTECH ABInventors: Johan Kreuger, Sara Thorslund, Zhigang Wu
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Publication number: 20200048680Abstract: A fluidic device has a culture chamber configured to house a 3D culture matrix comprising a culture of microorganisms. A concentration gradient of a test substance is established over the 3D culture matrix by providing respective fluid flows at different end portions of the culture chamber and comprising different concentrations of the test substance. The response of the microorganisms to the test substance is determined based on the position of a border zone in the 3D culture matrix.Type: ApplicationFiled: October 22, 2019Publication date: February 13, 2020Inventors: Johan KREUGER, Sara THORSLUND, Zhigang WU
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Patent number: 10487349Abstract: A fluidic device (1) has a culture chamber (10) configured to house a 3D culture matrix (2) comprising a culture of microorganisms (6). A concentration gradient of a test substance is established over the 3D culture matrix (2) by providing respective fluid flows at different end portions (12, 14) of the culture chamber (10) and comprising different concentrations of the test substance. The response of the microorganisms (6) to the test substance is determined based on the position of a border zone (5) in the 3D culture matrix (2).Type: GrantFiled: July 10, 2014Date of Patent: November 26, 2019Assignee: GRADIENTECH ABInventors: Johan Kreuger, Sara Thorslund, Zhigang Wu
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Publication number: 20160186231Abstract: A fluidic device (1) has a culture chamber (10) configured to house a 3D culture matrix (2) comprising a culture of microorganisms (6). A concentration gradient of a test substance is established over the 3D culture matrix (2) by providing respective fluid flows at different end portions (12, 14) of the culture chamber (10) and comprising different concentrations of the test substance. The response of the microorganisms (6) to the test substance is determined based on the position of a border zone (5) in the 3D culture matrix (2).Type: ApplicationFiled: July 10, 2014Publication date: June 30, 2016Inventors: Johan KREUGER, Sara THORSLUND, Zhigang WU
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Patent number: 8828332Abstract: A microfluidic capsule (1) comprises a top lid (100), a middle piece (200) and a bottom piece (300) to be assembled to enclose a microfluidic substrate (400) for analysis of cells and biochemical reactions. The middle piece (200) comprises support structures in the form of support pillars (250) and walls (240) around a central light window (220) to provide mechanical support and prevent tension-induced structural deformations. When fully assembled, light windows (120, 220, 230) in the top lid (100), middle piece (200) and bottom piece (300) allows inspection of biological and/or biochemical samples positioned in the enclosed microfluidic substrate (400).Type: GrantFiled: June 30, 2011Date of Patent: September 9, 2014Assignee: Gradientech ABInventors: Sara Thorslund, Johan Kreuger, Hugo Nguyen
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Publication number: 20130164192Abstract: A microfluidic capsule (1) comprises a top lid (100), a middle piece (200) and a bottom piece (300) to be assembled to enclose a microfluidic substrate (400) for analysis of cells and biochemical reactions. The middle piece (200) comprises support structures in the form of support pillars (250) and walls (240) around a central light window (220) to provide mechanical support and prevent tension-induced structural deformations. When fully assembled, light windows (120, 220, 230) in the top lid (100), middle piece (200) and bottom piece (300) allows inspection of biological and/or biochemical samples positioned in the enclosed microfluidic substrate (400).Type: ApplicationFiled: June 30, 2011Publication date: June 27, 2013Applicant: Gradientech ABInventors: Sara Thorslund, Johan Kreuger, Hugo Nguyen
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Patent number: 8387803Abstract: A particle sorting cell (10) comprises a cavity (12), an inlet (16) of a fluid flow (14) into the cavity, a first outlet (18) of a first part (22) of the fluid flow out from the cavity and a second outlet (20) of a second part (24) of the fluid flow out from the cavity. The second outlet is displaced from the first outlet in a first direction (Y) transverse to the flow direction (X). An acoustic generator (40) is arranged to apply an acoustic standing wave. The standing wave is transverse to the flow direction as well as to the first direction. A controller (42) is arranged to control a selective operation of the acoustic generator in dependence of an input data signal (44) associated with a particle (32) comprised in the fluid flow. The particle (32) can selectively be separated into the first outlet or the second outlet.Type: GrantFiled: August 26, 2008Date of Patent: March 5, 2013Assignee: GE Healthcare Bio-Sciences ABInventors: Sara Thorslund, Linda Johansson
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Publication number: 20120160746Abstract: A particle sorting cell (10) comprises a cavity (12), an inlet (16) of a fluid flow (14) into the cavity, a first outlet (18) of a first part (22) of the fluid flow out from the cavity and a second outlet (20) of a second part (24) of the fluid flow out from the cavity. The second outlet is displaced from the first outlet in a first direction (Y) transverse to the flow direction (X). An acoustic generator (40) is arranged to apply an acoustic standing wave. The standing wave is transverse to the flow direction as well as to the first direction. A controller (42) is arranged to control a selective operation of the acoustic generator in dependence of an input data signal (44) associated with a particle (32) comprised in the fluid flow. The particle (32) can selectively be separated into the first outlet or the second outlet.Type: ApplicationFiled: August 26, 2008Publication date: June 28, 2012Inventors: SARA THORSLUND, LINDA JOHANSSON
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Publication number: 20110217771Abstract: A fluidic culture device (100) comprises a substrate (101) of transparent polymer material with an open culture chamber (110) in the form of a hollow in a bottom surface (102) of the substrate (101). Open fluid channels (120, 130) flank the culture chamber (110) and have inlets (140, 150) and outlets (160) in a top or end surface (104, 106) of the substrate (101). Removable channel plugs (180, 190) are temporarily arranged in the portions of the fluid channels (120, 130) adjacent the culture chamber (110) to prevent culture matrix material poured into the culture chamber (110) from entering and blocking the fluid channels (120, 130). When assembling an operational culture system (230), a biological sample (210) is introduced in the culture matrix (200) and the channel plugs (180, 190) are removed. A transparent cover disk (220) is reversibly attached to the boom surface (102) to enclose the culture chamber (110) and the fluid channels (120, 130).Type: ApplicationFiled: November 6, 2009Publication date: September 8, 2011Inventors: Sara Thorslund, Johan Kreuger, Irmeli Barkefors