Abstract: The present invention relates to a long term storage stable multi-dose ready-to use or ready-to dilute pharmaceutical liquid formulation comprising pemetrexed or a pharmaceutically acceptable salt thereof, an antioxidant, a preservative, a buffering agent, and a pharmaceutically acceptable fluid. The invention also relates to a process of preparing the formulation, a kit and a method of treatment of patients having lung cancer by administering the pharmaceutical formulation to a subject in need thereof.

Abstract: The present disclosure involves systems, software, and computer implemented methods for intercepting data exchange requests and automatically imposing a hold period while the data exchange is evaluated for a user profile initiating the request. One example system includes operations to detect a data exchange request prior to completion of the attempted data exchange, the data exchange request including information defining the attempted data exchange and associated wherein the attempted data exchange is associated with a particular user profile. A portion of the information is transmitted to a data exchange analysis system for execution of a user profile-specific data exchange analysis based on the information and a status of the user profile. A hold state is initiated for the data exchange request while the analysis is performed. The results of the analysis are presented and a confirmation to proceed is required before allowing the attempted data exchange to be processed.

Abstract: A pharmaceutical long acting depot composition is provided as an aid to smoking cessation treatment. The formulation comprises a therapeutically effective amount of varenicline or its pharmaceutically acceptable derivative and pharmaceutically acceptable excipients. The process of preparation of the formulation is also provided.

Abstract: A method, apparatus and system for measuring a temperature can involve measuring a voltage with a resistance temperature detector using a variable excitation current, and deriving a process temperature from the voltage measured by the resistance temperature detector. The process temperature can be further derived by applying a plurality of values of the variable excitation current, measuring corresponding values of voltage, and estimating a resistance by applying a least square estimation. The process temperature can also be derived by applying a different value of the variable excitation current at every iteration, using a recursive least square estimation to measure a resistance, and using confidence intervals for instrument diagnostics.

Abstract: A data management device, communication system and methods for tagging data in a data table and triggering automated action. A data management device receives from a first data provider one or more records of a data table, each record comprising a plurality of fields. The data table is associated with an account having one or more authorized users. The plurality of fields each has a value set by the first data provider. The data manger determines one or more tags for the one or more records in accordance with a plurality of autotagging rules. The data manger appends the one or more records to include one or more tag fields corresponding to the one or more tags for the one or more records. The appended records are stored in a database. One or more automated actions may be triggered based on one or more tag fields of one or more of the plurality of records.

Abstract: A system and method for updating a component of a virtual computing system in a hyperconverged system includes installing, by a processor executing computer-readable instructions stored on a memory of a lifecycle manager of the virtual computing system, a software package on a node of the virtual computing system for updating the component of the virtual computing system, and booting, by the processor, the component into an update environment based on the software package. The software package decouples a dependency of the lifecycle manager on the update environment. The system and method also include updating, by the processor, the component in the update environment and booting, by the processor, the component out of the update environment into an operating environment upon completion of the update of the component.

Abstract: A system and method for updating a component of a virtual computing system in a hyperconverged system includes installing, by a processor executing computer-readable instructions stored on a memory of a lifecycle manager of the virtual computing system, a software package on a node of the virtual computing system for updating the component of the virtual computing system, and booting, by the processor, the component into an update environment based on the software package. The software package decouples a dependency of the lifecycle manager on the update environment. The system and method also include updating, by the processor, the component in the update environment and booting, by the processor, the component out of the update environment into an operating environment upon completion of the update of the component.

Abstract: The present invention relates to the formulation of midazolam. In particular, the invention provides new midazolam formulation for intranasal administration. These formulations contain midazolam in a high concentration from about 1% to about 10% w/w of the formulation and process of preparation thereof.

Abstract: A method, apparatus and system for measuring a temperature can involve measuring a voltage with a resistance temperature detector using a variable excitation current, and deriving a process temperature from the voltage measured by the resistance temperature detector. The process temperature can be further derived by applying a plurality of values of the variable excitation current, measuring corresponding values of voltage, and estimating a resistance by applying a least square estimation. The process temperature can also be derived by applying a different value of the variable excitation current at every iteration, using a recursive least square estimation to measure a resistance, and using confidence intervals for instrument diagnostics.

Abstract: The present invention relates to a long term storage stable multi-dose ready-to use or ready-to dilute pharmaceutical liquid formulation comprising pemetrexed or a pharmaceutically acceptable salt thereof, an antioxidant, a preservative, a buffering agent, and a pharmaceutically acceptable fluid. The invention also relates to a process of preparing the formulation, a kit and a method of treatment of patients having lung cancer by administering the pharmaceutical formulation to a subject in need thereof.

Abstract: A pharmaceutical long acting depot composition is provided as an aid to smoking cessation treatment. The formulation comprises a therapeutically effective amount of varenicline or its pharmaceutically acceptable derivative and pharmaceutically acceptable excipients. The process of preparation of the formulation is also provided.

Abstract: A device may determine a behavioral pattern of an account over a past time period based on data relating to one or more transactions associated with the account. The device may identify one or more quantitative features of the behavioral pattern and one or more spatial features of the behavioral pattern. The device may determine an account type cluster to which the account belongs, based on the one or more quantitative features and the one or more spatial features identified. The device may determine, based on the account type cluster that is determined, a model for processing the behavioral pattern. The device may predict, using the model that is determined, an amount of funds that is likely to remain in the account during a future time period. The device may perform one or more actions based on the amount of funds that is predicted.

Abstract: A method includes obtaining different measurements of voltages across terminals of a field device coupled to an I/O loop. The voltage measurements are associated with corresponding loop currents flowing through the I/O loop. The method also includes identifying a baseline loop resistance measurement of the I/O loop using the voltage measurements and the loop currents. The method further includes obtaining additional measurements of voltages across the terminals of the field device. The additional voltage measurements are associated with additional corresponding loop currents flowing through the I/O loop. The method also includes identifying additional loop resistance measurements of the I/O loop using the additional voltage measurements and the additional loop currents. In addition, the method includes detecting a problem with the I/O loop based on the baseline loop resistance measurement and the additional loop resistance measurements.

Abstract: A method and system are provided for processing context data for interaction sessions for providing a subset of the context data for a first interaction session. The method includes detecting the first interaction session between a request initiator and a request service provider, and obtaining context data of a plurality of other interaction sessions. The context data is related to activity of the request initiator. The method also includes selecting the subset of the context data based on at least one of relevance, similarities and differences to at least one of the first interaction session and type of interaction channel. The subset of the context data is then provided for the first interaction session.

Abstract: The present invention relates to a long term storage stable multi-dose ready-to use or ready-to dilute pharmaceutical liquid formulation comprising pemetrexed or a pharmaceutically acceptable salt thereof, an antioxidant, a preservative, a buffering agent, and a pharmaceutically acceptable fluid. The invention also relates to a process of preparing the formulation, a kit and a method of treatment of patients having lung cancer by administering the pharmaceutical formulation to a subject in need thereof.

Abstract: The present disclosure involves systems, software, and computer implemented methods for personalizing interactions within a conversational interface based on an input context. One example system performs operations including receiving a conversational input received via a conversational interface. The conversational input is analyzed to determine an intent and lexical personality score based on the input's characteristics. A set of responsive content is determined and includes a set of initial tokens representing an initial response. A set of synonym tokens associated with at least some of the initial tokens are identified, and at least one synonym token associated with a similar lexical personality score to the input is determined. At least one of the initial tokens are replaced with the determined synonym token to generate a modified version of the set of response content. The modified version of the response is then transmitted to a device in response to the input.

Abstract: Systems and methods are provided for, are provided for analyzing each of a plurality of documents related to a person to identify content attributes that occur in a dictionary for behavior or personality traits, calculating an initial score for each behavior and personality trait related to the identified content attributes, calculating trait metrics for each behavior or personality trait by combining initial scores for each behavior or personality trait, providing the trait metrics as input to a rule based scoring and machine learning system, obtaining, from the rule based scoring and machine learning system, a trustworthiness score of the person output from the rule based scoring and machine learning system, receiving an indication that a second person trusts the person, creating a relationship between the second person and the person, and adjusting the trustworthiness score of the person based on, at least, a trustworthiness score of the second person.

Abstract: Methods and devices for generated and handling an alert are described. In one aspect, an electronic device includes an input interface and an output interface. The electronic device also includes a memory storing an application and a processor coupled to the input interface, the output interface and the memory. The processor is configured to generate a selectable alert on the output interface while the electronic device is in a device lock mode. The selectable alert is associated with the secure application. The processor is also configured to, while the electronic device is in the device lock mode, receive, from the input interface, a signal representing a command to activate the selectable alert. The processor is also configured to, responsive to receiving the command to activate the selectable alert, execute a secure event in the secure application while the electronic device remains in the device lock mode.

Abstract: Disclosed herein are improved formulations for the cabazitaxel. The formulations exhibit increased storage stability relative to other formulations, and are simpler for health care providers to prepare and administer to patients.

Abstract: A pharmaceutical long acting depot composition is provided as an aid to smoking cessation treatment. The formulation comprises a therapeutically effective amount of varenicline or its pharmaceutically acceptable derivative and pharmaceutically acceptable excipients. The process of preparation of the formulation is also provided.