Abstract: The present invention provides a formulation of fenofibrate with enhanced oral bioavailability, simplicity of design and manufacture and absence of food effect. The formulation comprises fenofibrate dissolved in a lipophilic surfactant, with a hydrophilic surfactant optionally added. The formulation can be effectively used in the management and treatment of conditions such as hypertriglyceridemia, hypercholesterolemia and mixed dyslipidemia, and can also be effective at lower doses as compared to commercially available products. The invention additionally relates to the process of manufacture of the formulation and to dosage forms comprising the same.

Abstract: The invention relates to a modified release pharmaceutical composition comprising ramipril or pharmaceutically acceptable salts thereof and pharmaceutically acceptable excipient(s) wherein pharmaceutical composition is bioequivalent to conventional immediate release formulation of ramipril administered twice daily. The invention further relates to a modified release pharmaceutical composition comprising: an immediate release component comprising ramipril or pharmaceutically acceptable salts thereof and a modified release component comprising ramipril or pharmaceutically acceptable salts thereof. The invention further relates to the process for the preparation of modified release pharmaceutical composition of ramipril.

Abstract: The present invention discloses compositions having particles comprising, inorganic element; one or more active ingredient and optionally a release rate modulating agent, suitable for the delivery of active ingredients to human and animal tissues. The particles are nanoparticles or microparticles or mixtures thereof, made preferably by sol-gel method. The compositions are useful for application to the topical or mucosal surfaces preferably in the form of creams, gels, lotions, dry powders, spray, foam and other suitable forms.

Abstract: The present invention provides a modified release dosage form of tacrolimus that releases two or more amount of tacrolimus upon oral administration, the first amount of tacrolimus releases from the immediate release dosage unit substantially immediately within 0-2 hours followed by a time interval ranging from about 1-10 hours during which substantially no amount of tacrolimus is released from the dosage form, after which a second amount of tacrolimus is released wherein said second amount is released from the delayed release dosage unit either immediately e.g. within 0-2 hours or over a period of time ranging from about 2-12 hours from its initial release from the delayed release dosage unit. The dosage form may further comprise additional amount of tacrolimus to provide additional pulse of tacrolimus. The dosage forms of tacrolimus exhibit improved bioavailability and reduced flux or fluctuation over existing composition of tacrolimus. A method of preparing the dosage forms is also described.

Abstract: The present invention is concerned with a system for spatially and temporally programmable delivery of an active agent. When administered orally, the System can be retained in the gastric region for a prolonged period of time. It comprises of a core (I), one or more layers (II, IV, V) coated over the core and a preformed hollow space (III). The invention also concerns with a process for preparation of the System and a method for treating/preventing diseases, by administering to a subject in need thereof, the System of the invention.

Abstract: The invention provides a method and a composition for producing an anti-androgenic effect in a mammal. The method comprises administering a modified release pharmaceutical composition of bicalutamide to a mammal, with a reduced dosing frequency, for improved patient convenience and compliance. The composition of the invention also provides for a higher bioavailability and improved pharmacokinetic profile as compared to a conventional bicalutamide composition.

Abstract: A method of configuring a mobile device allows an administrator to select multiple installation items from a set of possible installation items to include in a deployment package. At least one of the installation items includes parameters provided by an administrator that are requested from the administrator based on a configuration file associated with the installment items. The deployment package is transferred to a mobile device and the parameter values are extracted and are used to configure the mobile device.

Abstract: Methods for extraction of carotenoids from carotenoid-containing plant material using an extraction solvent comprising ethyl lactate. The invention is also directed to products obtained thereby. In the method, a sample of dry, particulate carotenoid-containing plant material is contacted with the ethyl lactate extraction solvent to extract the carotenoids. The method also includes the use of an ethyl lactate-ethanol blend as the extraction solvent. After extraction, the solvent containing the extracted carotenoids is separated from the extracted plant solids and treated to separate the dissolved carotenoids from the extraction solvent and obtain a carotenoid-containing concentrate. The concentrated carotenoid product may be used directly or may be subjected to further treatment. After removal of the dissolved carotenoids, the extraction solvent can be recycled for further use.

Abstract: The invention provides a composition for delivering active agents through transmucosal administration, more particularly through the buccal mucosa. The composition is a unique transmucosal disk (10) which has two compartments (14) and (18); the compartments consist of at least one active agent and at least one mucoadhesive agent and both the compartments are adapted to be in contact with the mucosal membrane. The invention also provides for transmucosal administration of an active agent and method of treatment of diseases in a subject in need of such treatment.

Abstract: Given a three legged network setup, the method will automatically check necessary settings to ensure that a business application can be set up to be available over the Internet.

Abstract: This invention describes a post-recognition procedure to group text recognized by an Optical Character Reader (OCR) from a document image into zones. Once the recognized text and the corresponding word bounding boxes for each word of the text are received, the procedure described dilates (expands) these word bounding boxes by a factor and records those which cross. Two word bounding boxes will cross upon dilation if the corresponding words are very close to each other on the original document. The text is then grouped into zones using the rule that two words will belong to the same zone if their word bounding boxes cross upon dilation. The text zones thus identified are sorted and returned.

Abstract: A method of configuring a mobile device allows an administrator to select multiple installation items from a set of possible installation items to include in a deployment package. At least one of the installation items includes parameters provided by an administrator that are requested from the administrator based on a configuration file associated with the installment items. The deployment package is transferred to a mobile device and the parameter values are extracted and are used to configure the mobile device.

Abstract: A method for reforming a sulfur-containing carbonaceous fuel in which the sulfur-containing carbonaceous fuel is mixed with H2O and an oxidant, forming a fuel/H2O/oxidant mixture. The fuel H2O/oxidant mixture is brought into contact with a catalyst composition comprising a dehydrogenation portion, an oxidation portion and a hydrodesulfurization portion, resulting in formation of a hydrogen-containing gas stream.

Abstract: A method for reforming a sulfur-containing carbonaceous fuel in which the sulfur-containing carbonaceous fuel is mixed with H2O and an oxidant, forming a fuel/H2O/oxidant mixture. The fuel H2O/oxidant mixture is brought into contact with a catalyst composition comprising a dehydrogenation portion, an oxidation portion and a hydrodesulfurization portion, resulting in formation of a hydrogen-containing gas stream.

Abstract: A multi-part catalyst composition having a dehydrogenation portion, an oxidation portion and a hydrodesulfurization portion. The catalyst composition is suitable for reforming a sulfur-containing carbonaceous fuel.

Abstract: A tractor belt adapted to be trained over and driven and supported by sprockets in a mechanism for advancing and positioning a strip of material having hole-in-line perforations, the belt comprising a wire-cored band having perforation engaging lugs integral with and projecting from one surface of the band and sprocket engaging lugs integral with and projecting from the opposite surface of the band. A method for making such a belt.