Patents by Inventor Saradha Avantsa
Saradha Avantsa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200240883Abstract: This disclosure provides a biological sample processing system and methods for processing biological samples. The processing may include one or both of removing wax from wax-embedded biological samples and applying a reagent to biological samples. Aspects of the dewaxing technique and the technique for applying the reagent may be combined to achieve energy efficiencies. Additional efficiency may be achieved by recirculating heated reagent. A hybrid power system may use a source of stored power to supplement external power at times of peak demand. Uniform distribution of liquids across a surface of the biological samples may be achieved by self-leveling using an inclinometer.Type: ApplicationFiled: April 15, 2020Publication date: July 30, 2020Applicant: Biocare Medical, LLCInventors: David Abraham Basiji, Eric Andrew Warner, Saradha Avantsa, Hoa Thuong Nguyen, Smitha Sreedhar, Thomas Marion Maxwell, Ziggy Q. Kotchetkov, Kathlyn Leigh Rettig, Deidra Imani Jackson, Ravishankar Melkote, Zhiweng Chang, Maria Lourdes Teixeira
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Patent number: 10656057Abstract: This disclosure provides a biological sample processing system and methods for processing biological samples. The processing may include one or both of removing wax from wax-embedded biological samples and applying a reagent to biological samples. Aspects of the dewaxing technique and the technique for applying the reagent may be combined to achieve energy efficiencies. Additional efficiency may be achieved by recirculating heated reagent. A hybrid power system may use a source of stored power to supplement external power at times of peak demand. Uniform distribution of liquids across a surface of the biological samples may be achieved by self-leveling using an inclinometer.Type: GrantFiled: April 28, 2017Date of Patent: May 19, 2020Assignee: Biocare Medical, LLCInventors: David Abraham Basiji, Eric Andrew Warner, Saradha Avantsa, Hoa Thuong Nguyen, Smitha Sreedhar, Thomas Marion Maxwell, Ziggy Q. Kotchetkov, Kathlyn Leigh Rettig, Deidra Imani Jackson, Ravishankar Melkote, Zhiweng Chang, Maria Lourdes Teixeira
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Publication number: 20170315032Abstract: This disclosure provides a biological sample processing system and methods for processing biological samples. The processing may include one or both of removing wax from wax-embedded biological samples and applying a reagent to biological samples. Aspects of the dewaxing technique and the technique for applying the reagent may be combined to achieve energy efficiencies. Additional efficiency may be achieved by recirculating heated reagent. A hybrid power system may use a source of stored power to supplement external power at times of peak demand. Uniform distribution of liquids across a surface of the biological samples may be achieved by self-leveling using an inclinometer.Type: ApplicationFiled: April 28, 2017Publication date: November 2, 2017Inventors: David Abraham Basiji, Eric Andrew Warner, Saradha Avantsa, Hoa Thuong Nguyen, Smitha Sreedhar, Thomas Marion Maxwell, Ziggy Q. Kotchetlov, Kathlyn Leigh Rettig, Deidra Imani Jackson, Ravishankar Melkote, Zhiweng Chang, Maria L. Lourdes Teixeira
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Patent number: 9442049Abstract: Systems and methods of sample and staining processing including compression and dynamic movement of liquids in a fluidically moving substantially contained liquid bridge perhaps between a hydrophobic wand and a hydrophilic sample support element. Embodiments may include low volume reagent and perhaps even low volume buffer wash in sample processing. In addition, antibodies can be conjugated with nanoparticles and can be used in sample processing. Exposing a sample with or without movement to AC, DC, or even a permanent magnet field may improve staining. Staining with nanoparticle reagents could be quantified using a microscope with a magnetometer below the slide viewing area. The detection of nanoparticles attached to the chemistry may facilitate the quantification of cancerous cells stained in the tissue.Type: GrantFiled: July 9, 2013Date of Patent: September 13, 2016Assignee: Biocare Medical, LLCInventors: Stephen Barker, Saradha Avantsa
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Methods and systems for efficient automatic slide staining in immunohistochemistry sample processing
Patent number: 8765476Abstract: Automated sample processing systems may include onboard efficient high-speed mixing of at least two components with an automatic vertical force fluidic turbulent component mixer of which a mixed component may be aspirated and high-speed dispensed in a mixing vial. Other aspects may include single sweep applying a multi-treatment cleaning cycle to at least one slide. A multi-treatment cleaning cycle may include a washing treatment and a drying treatment. In yet other aspects the present invention may include an automated recovery sample processing system with the capability of detecting at least one immediate condition of a fortuitously terminated automatic sample processing run and perhaps even an automatic terminated sample processing run reconstruction calculator.Type: GrantFiled: December 22, 2009Date of Patent: July 1, 2014Assignee: Biocare Medical, LLCInventors: Saradha Avantsa, Ravishankar Melkote, Thomas Maxwell, Geoffrey Cook -
Publication number: 20130309688Abstract: Systems and methods of sample and staining processing including compression and dynamic movement of liquids in a fluidically moving substantially contained liquid bridge perhaps between a hydrophobic wand and a hydrophilic sample support element. Embodiments may include low volume reagent and perhaps even low volume buffer wash in sample processing. In addition, antibodies can be conjugated with nanoparticles and can be used in sample processing. Exposing a sample with or without movement to AC, DC, or even a permanent magnet field may improve staining. Staining with nanoparticle reagents could be quantified using a microscope with a magnetometer below the slide viewing area. The detection of nanoparticles attached to the chemistry may facilitate the quantification of cancerous cells stained in the tissue.Type: ApplicationFiled: July 9, 2013Publication date: November 21, 2013Inventors: Stephen Barker, Saradha Avantsa
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Patent number: 8501434Abstract: Systems and methods of sample (1) and staining processing including compression and dynamic movement of liquids (3) in a fluidically moving substantially contained liquid bridge (6) perhaps between a hydrophobic wand (4) and a hydrophilic sample support element (2). Embodiments may include low volume reagent and perhaps even low volume buffer wash in sample processing. In addition, antibodies can be conjugated with nanoparticles (64) and can be used in sample processing. Exposing a sample with or without movement to AC, DC, or even a permanent magnet field may improve staining. Staining with nanoparticle reagents could be quantified using a microscope with a magnetometer below the slide viewing area. The detection of nanoparticles attached to the chemistry may facilitate the quantification of cancerous cells stained in the tissue.Type: GrantFiled: May 3, 2012Date of Patent: August 6, 2013Assignee: Biocare, LLCInventors: Stephen Barker, Saradha Avantsa
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Publication number: 20120214191Abstract: Systems and methods of sample (1) and staining processing including compression and dynamic movement of liquids (3) in a fluidically moving substantially contained liquid bridge (6) perhaps between a hydrophobic wand (4) and a hydrophilic sample support element (2). Embodiments may include low volume reagent and perhaps even low volume buffer wash in sample processing. In addition, antibodies can be conjugated with nanoparticles (64) and can be used in sample processing. Exposing a sample with or without movement to AC, DC, or even a permanent magnet field may improve staining. Staining with nanoparticle reagents could be quantified using a microscope with a magnetometer below the slide viewing area. The detection of nanoparticles attached to the chemistry may facilitate the quantification of cancerous cells stained in the tissue.Type: ApplicationFiled: May 3, 2012Publication date: August 23, 2012Applicant: BIOCARE MEDICAL, LLCInventors: Stephen Barker, Saradha Avantsa
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Methods and Systems for Efficient Automatic Slide Staining in Immunohistochemistry Sample Processing
Publication number: 20110151504Abstract: Automated sample processing systems may include onboard efficient high-speed mixing of at least two components with an automatic vertical force fluidic turbulent component mixer of which a mixed component may be aspirated and high-speed dispensed in a mixing vial. Other aspects may include single sweep applying a multi-treatment cleaning cycle to at least one slide. A multi-treatment cleaning cycle may include a washing treatment and a drying treatment. In yet other aspects the present invention may include an automated recovery sample processing system with the capability of detecting at least one immediate condition of a fortuitously terminated automatic sample processing run and perhaps even an automatic terminated sample processing run reconstruction calculator.Type: ApplicationFiled: December 22, 2009Publication date: June 23, 2011Applicant: BIOCARE MEDICAL, LLCInventors: Saradha Avantsa, Ravishankar Melkote, Thomas Maxwell, Geoffrey Cook