Patents by Inventor Sarah Burroughs Tencza

Sarah Burroughs Tencza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microbead-based test methods for fluorescence imaging systems
    Patent number: 7482167
    Abstract: The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: January 27, 2009
    Assignee: Cellomics, Inc.
    Inventors: Paul Sammak, Gustavo Rosania, Lawrence J. Zana, Kim Ippolito, Jason Bush, Alex Friedman, Sarah Burroughs Tencza, Ravi Kapur
  • Peptide biosensors for anthrax protease
    Patent number: 7410769
    Abstract: The present invention provides a protease biosensor that can be used to detect the presence of the lethal factor protease from Bacillus anthracis, as well as methods for using the protease biosensor.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: August 12, 2008
    Assignee: Cellomics Inc.
    Inventor: Sarah Burroughs-Tencza
  • System for cell-based screening
    Publication number: 20060094868
    Abstract: The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions.
    Type: Application
    Filed: October 17, 2005
    Publication date: May 4, 2006
    Inventors: Kenneth Giuliano, Gary Bright, Keith Olson, Sarah Burroughs-Tencza
  • Microbead-based test plates and test methods for fluorescence imaging systems
    Publication number: 20050176056
    Abstract: The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.
    Type: Application
    Filed: March 11, 2005
    Publication date: August 11, 2005
    Inventors: Paul Sammak, Gustavo Rosania, Lawrence Zana, Kim Ippolito, Jason Bush, Alex Friedman, Sarah Burroughs Tencza, Ravi Kapur
  • Microbead-based test plates and test methods for fluorescence imaging systems
    Patent number: 6905881
    Abstract: The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: June 14, 2005
    Inventors: Paul Sammak, Gustavo Rosania, Lawrence J. Zana, Kim Ippolito, Jason Bush, Alex Friedman, Sarah Burroughs Tencza, Ravi Kapur
  • System for cell-based screening
    Patent number: 6756207
    Abstract: The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect particular biological functions.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: June 29, 2004
    Assignee: Cellomics, Inc.
    Inventors: Kenneth A. Giuliano, Gary Bright, Keith Olson, Sarah Burroughs Tencza
  • Peptide biosensors for anthrax protease
    Publication number: 20030166028
    Abstract: The present invention provides a protease biosensor that can be used to detect the presence of the lethal factor protease from Bacillus anthracis, as well as methods for using the protease biosensor.
    Type: Application
    Filed: November 22, 2002
    Publication date: September 4, 2003
    Inventor: Sarah Burroughs-Tencza
  • Microbead-based test plates and test methods for fluorescence imaging systems
    Publication number: 20020098588
    Abstract: The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface.
    Type: Application
    Filed: November 30, 2001
    Publication date: July 25, 2002
    Inventors: Paul Sammak, Gustavo Rosania, Lawrence J. Zana, Kim Ippolito, Jason Bush, Alex Friedman, Sarah Burroughs Tencza, Ravi Kapur
  • Peptide biosensors for anthrax protease
    Publication number: 20020076741
    Abstract: The present invention provides a protease biosensor that can be used to detect the presence of the lethal factor protease from Bacillus anthracis, as well as methods for using the protease biosensor.
    Type: Application
    Filed: February 9, 2001
    Publication date: June 20, 2002
    Inventor: Sarah Burroughs Tencza
  • Antimicrobial peptides
    Patent number: 5945507
    Abstract: The invention is directed to antimicrobial peptides which correspond in sequence to selective amino acid sequences in viral transmembrane proteins. In particular, the proteins are derived from lentiviruses, primarily HIV and SIV. The peptides comprise arginine-rich sequences, which, when modeled for secondary structure, display a high amphipathicity and hydrophobic moment. They are highly inhibitory to microorganisms, while being significantly less active in regard to mammalian cells. As a result, the peptides of the invention may be defined as selective antimicrobial agents. The invention is also directed to antimicrobial peptides which are structural and functional analogs and homologs of the peptides and which exhibit selective inhibitory activity towards microorganisms. The invention is also directed to pharmaceutical compositions comprising the antimicrobial peptides of the invention and to methods for their use in inhibiting microbial growth and treatment of microbial infections.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: August 31, 1999
    Assignee: University of Pittsburgh
    Inventors: Ronald C. Montelaro, Sarah Burroughs Tencza, Timothy A. Mietzner
  • Antimicrobial peptides
    Patent number: 5714577
    Abstract: The invention is directed to antimicrobial peptides which correspond in sequence to selective amino acid sequences in viral transmembrane proteins. In particular, the proteins are derived from lentiviruses, primarily HIV and SIV. The peptides comprise arginine-rich sequences, which, when modeled for secondary structure, display a high amphipathicity and hydrophobic moment. They are highly inhibitory to microorganisms, while being significantly less active in regard to mammalian cells. As a result, the peptides of the invention may be defined as selective antimicrobial agents. The invention is also directed to antimicrobial peptides which are structural and functional analogs and homologs of the peptides and which exhibit selective inhibitory activity towards microorganisms. The invention is also directed to pharmaceutical compositions comprising the antimicrobial peptides of the invention and to methods for their use in inhibiting microbial growth and treatment of microbial infections.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: February 3, 1998
    Assignee: University of Pittsburgh
    Inventors: Ronald C. Montelaro, Sarah Burroughs Tencza, Timothy A. Mietzner