Patents by Inventor Sarah C. Garrett-Thomson

Sarah C. Garrett-Thomson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof
    Patent number: 11339201
    Abstract: The present disclosure provides variant PD-L1 immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: May 24, 2022
    Assignee: Albert Einstein College of Medicine
    Inventors: Sarah C. Garrett-Thomson, Steven C. Almo, Ronald D. Seidel, III
  • Methods for high throughput receptor:ligand identification
    Patent number: 11226339
    Abstract: Methods and systems for high-throughput Identification of receptor:ligand interactions are provided. Throughout this application various publications are referred to in parentheses. Full citations for these references may be found at the end of the specification. The disclosures of these publications, and all patents, patent application publications and books referred to herein, are hereby incorporated by reference in their entirety into the subject application to more fully describe the art to which the subject invention pertains.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: January 18, 2022
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
    Inventors: Steven C. Almo, Ronald D. Seidel, III, Brandan S. Hillerich, Sarah C. Garrett-Thomson, James D. Love
  • METHODS FOR HIGH THROUGHPUT RECEPTOR:LIGAND IDENTIFICATION
    Publication number: 20200011875
    Abstract: Methods and systems for high-throughput Identification of receptor: ligand interactions are provided. Throughout this application various publications are referred to in parentheses. Full citations for these references may be found at the end of the specification. The disclosures of these publications, and all patents, patent application publications and books referred to herein, are hereby incorporated by reference in their entirety into the subject application to more fully describe the art to which the subject invention pertains.
    Type: Application
    Filed: July 25, 2018
    Publication date: January 9, 2020
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE
    Inventors: Steven C. Almo, Ronald D. Seidel, III, Brandan S. Hillerich, Sarah C. Garrett-Thomson, James D. Love
  • VARIANT PD-L1 POLYPEPTIDES, T-CELL MODULATORY MULTIMERIC POLYPEPTIDES, AND METHODS OF USE THEREOF
    Publication number: 20190153065
    Abstract: The present disclosure provides variant PD-L1 immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.
    Type: Application
    Filed: May 17, 2017
    Publication date: May 23, 2019
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
    Inventors: Sarah C. Garrett-Thomson, Steven C. Almo, Ronald D. Seidel III
  • Methods for high throughput receptor:ligand identification
    Patent number: 10048271
    Abstract: Methods and systems for high-throughput identification of receptor:ligand interactions are provided.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: August 14, 2018
    Assignee: Albert Einstein College of Medicine, Inc.
    Inventors: Steven C. Almo, Ronald D. Seidel, III, Brandan S. Hillerich, Sarah C. Garrett-Thomson, James D. Love
  • METHODS FOR HIGH THROUGHPUT RECEPTOR:LIGAND IDENTIFICATION
    Publication number: 20160011204
    Abstract: Methods and systems for high-throughput identification of receptor:ligand interactions are provided.
    Type: Application
    Filed: December 5, 2013
    Publication date: January 14, 2016
    Inventors: Steven C. Almo, Ronald D. Seidel, III, Brandan S. Hillerich, Sarah C. Garrett-Thomson, James D. Love