Abstract: The present invention relates to synthetic receptors for ionophoric compounds, such as ionophoric toxins. Hence, the invention provides synthetic molecules capable of binding different ionophoric compounds, thereby being suitable for use in the detection, isolation and detoxification of such ionophoric compounds. The present invention further provides the use of such synthetic receptors in human and veterinary medicine, such as in the diagnosis, prevention and/or treatment of disorders caused by such ionophoric compounds. Finally, the invention provides methods of preparing such synthetic receptors for ionophoric compounds.

Abstract: The present invention relates to synthetic receptors for ionophoric compounds, such as ionophoric toxins. Hence, the invention provides synthetic molecules capable of binding different ionophoric compounds, thereby being suitable for use in the detection, isolation and detoxification of such ionophoric compounds. The present invention further provides the use of such synthetic receptors in human and veterinary medicine, such as in the diagnosis, prevention and/or treatment of disorders caused by such ionophoric compounds. Finally, the invention provides methods of preparing such synthetic receptors for ionophoric compounds.

Abstract: This disclosure relates to determining the stress level experienced by fish over a long period of time, which can be used in assessing the welfare status of fish. More, in particular, this disclosure relates to the usage of scales as well as other calcified tissue such as otoliths, spines and soft fin ray sampled from fish to quantify glucocorticoid levels in the scales/matrix. The levels of the glucocorticoids, such as cortisol or corticosterone, build up over time in scales and reflect long-lasting and stressful conditions that the fish have undergone during their lives and that have affected their level of stress. Hence, in vitro methods are disclosed herein that quantify the level of chronic stress in fish using scales as a logistic feasible, and non-invasive matrix for accurate and precise quantification of stress hormones.

Abstract: This disclosure relates to determining the stress level experienced by fish over a long period of time, which can be used in assessing the welfare status of fish. More, in particular, this disclosure relates to the usage of scales as well as other calcified tissue such as otoliths, spines and soft fin ray sampled from fish to quantify glucocorticoid levels in the scales/matrix. The levels of the glucocorticoids, such as cortisol or corticosterone, build up over time in scales and reflect long-lasting and stressful conditions that the fish have undergone during their lives and that have affected their level of stress. Hence, in vitro methods are disclosed herein that quantify the level of chronic stress in fish using scales as a logistic feasible, and non-invasive matrix for accurate and precise quantification of stress hormones.