Abstract: A system includes a sheet flexible material having a contact surface adapted to be placed on an outer surface of a patient's body. A plurality of sensing apparatuses have respective sensing surfaces distributed across the contact surface of the sheet. One or more of the sensing apparatuses include a multimodal sensing apparatus. Each multimodal sensing apparatus includes a monolithic substrate carrying a transducer, circuitry and an electrophysiological sensor. The transducer is coupled to the circuitry and configured to at least sense acoustic energy from a transducer location of the sheet. The electrophysiological sensor is also coupled to the circuitry, and the sensor is configured to at least sense electrophysiological signals from a sensor location of the sheet, in which the sensor location has a known spatial position relative to the transducer location.

Abstract: An example system for use in ablating target tissue includes memory configured to store anatomical and/or physiological information of a patient and processing circuitry communicatively coupled to the memory. The processing circuitry is configured to, based on the anatomical information and/or the physiological information, determine ablation parameters, the ablation parameters including a suggested positioning of at least energy delivery element of at least one catheter and/or an amount of energy to be delivered via the at least one energy delivery element to the target tissue during ablation. The processing circuitry is configured to output, for display, a representation of at least one of a suggested positioning of the at least one energy delivery element during the ablation, a representation of the target tissue, or a representation of the predicted tissue volume that will be ablated after delivery of ablation energy.

Abstract: Various embodiments of a system for guiding an instrument through a region of a patient are disclosed. The system includes an instrument and a controller that is adapted to receive ultrasound image data from an ultrasound sensor, receive EM tracking data from an EM tracking system, and identify a physiological landmark of the region of the patient based on the ultrasound image data. The controller is further adapted to determine at least one of a position, orientation, or trajectory of the instrument based on the EM tracking data and generate a graphical user interface showing at least one of the position, orientation, or trajectory of the instrument in relation to a plane of the ultrasound image data, and a target zone that is registered with the physiological landmark.

Abstract: In an example, a system includes an ultrasound sensor configured to transmit ultrasound energy and receive ultrasound energy reflected in a region of a patient and one or more processors configured to generate a reference ultrasound image of the region of the patient based on a portion of the ultrasound energy that was received by the ultrasound sensor prior to a medical instrument or medical device causing obstruction in the received ultrasound energy, generate a live ultrasound image based on a current portion of the received ultrasound energy obtained by the ultrasound sensor, register the reference ultrasound image and the live ultrasound image, and control a display device to display the reference ultrasound image with at least a portion of the live ultrasound image.

Abstract: In an example, a system includes an ultrasound sensor configured to transmit ultrasound energy and receive ultrasound energy reflected in a region of a patient and one or more processors configured to generate a reference ultrasound image of the region of the patient based on a portion of the ultrasound energy that was received by the ultrasound sensor prior to a medical instrument or medical device causing obstruction in the received ultrasound energy, generate a live ultrasound image based on a current portion of the received ultrasound energy obtained by the ultrasound sensor, register the reference ultrasound image and the live ultrasound image, and control a display device to display the reference ultrasound image with at least a portion of the live ultrasound image.

Abstract: Various embodiments of a system for guiding an instrument through a region of a patient are disclosed. The system includes an instrument and a controller that is adapted to receive ultrasound image data from an ultrasound sensor, receive EM tracking data from an EM tracking system, and identify a physiological landmark of the region of the patient based on the ultrasound image data. The controller is further adapted to determine at least one of a position, orientation, or trajectory of the instrument based on the EM tracking data and generate a graphical user interface showing at least one of the position, orientation, or trajectory of the instrument in relation to a plane of the ultrasound image data, and a target zone that is registered with the physiological landmark.

Abstract: Various embodiments of a system for guiding an instrument through a region of a patient are disclosed. The system includes an instrument and a controller that is adapted to receive ultrasound image data from an ultrasound sensor, receive EM tracking data from an EM tracking system, and identify a physiological landmark of the region of the patient based on the ultrasound image data. The controller is further adapted to determine at least one of a position, orientation, or trajectory of the instrument based on the EM tracking data and generate a graphical user interface showing at least one of the position, orientation, or trajectory of the instrument in relation to a plane of the ultrasound image data, and a target zone that is registered with the physiological landmark.

Abstract: A method of ablating an epicardial tissue region, including positioning a medical device adjacent the epicardial tissue region, the medical device having a first electrode, a second electrode, and a third electrode located in between the first and second electrodes; delivering an irrigation fluid to the tissue region; and ablating at least a portion of the tissue region by sequentially activating the third electrode in a monopolar radiofrequency delivery mode and activating the first and second electrodes in a bipolar radiofrequency delivery mode.

Abstract: A method of ablating an epicardial tissue region, including positioning a medical device adjacent the epicardial tissue region, the medical device having a first electrode, a second electrode, and a third electrode located in between the first and second electrodes; delivering an irrigation fluid to the tissue region; and ablating at least a portion of the tissue region by sequentially activating the third electrode in a monopolar radiofrequency delivery mode and activating the first and second electrodes in a bipolar radiofrequency delivery mode.

Abstract: A method of ablating an epicardial tissue region, including positioning a medical device adjacent the epicardial tissue region, the medical device having a first electrode, a second electrode, and a third electrode located in between the first and second electrodes; delivering an irrigation fluid to the tissue region; and ablating at least a portion of the tissue region by sequentially activating the third electrode in a monopolar radiofrequency delivery mode and activating the first and second electrodes in a bipolar radiofrequency delivery mode.

Abstract: A method of ablating an epicardial tissue region, including positioning a medical device adjacent the epicardial tissue region, the medical device having a first electrode, a second electrode, and a third electrode located in between the first and second electrodes; delivering an irrigation fluid to the tissue region; and ablating at least a portion of the tissue region by sequentially activating the third electrode in a monopolar radiofrequency delivery mode and activating the first and second electrodes in a bipolar radiofrequency delivery mode.