Patents by Inventor Sarah E. THACKER

Sarah E. THACKER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STEM-LOOP COMPOSITIONS AND METHODS FOR INHIBITING VASCULAR ENDOTHELIAL GROWTN FACTOR
    Publication number: 20220098591
    Abstract: The application discloses methods and compositions for inhibiting functions associated with vascular endothelial growth factor-A (VEGF-A). The methods and compositions may involve the use of pan-variant specific aptamers for binding to VEGF-A, and preventing or reducing association of VEGF-A with Flt-1, KDR, or Nrp-1. The methods and compositions may include one or more aptamers that bind to receptor binding face of VEGF-A. The methods and compositions may include one or more aptamers that bind to a receptor binding domain of VEGF-A. The application further provides anti-VEGF-A aptamers for the treatment of ocular diseases or disorders. In some cases, the anti-VEGF-A aptamers may have a stem-loop secondary structure.
    Type: Application
    Filed: January 10, 2020
    Publication date: March 31, 2022
    Applicants: DRIVE THERAPEUTICS LLC, ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
    Inventors: Carl ERICKSON, Christopher P. RUSCONI, Matthew LEVY, Keith E. MAIER, Sarah E. THACKER, Derek PARKS