Patents by Inventor Sarah Elizabeth Bettigole

Sarah Elizabeth Bettigole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IRE1 small molecule inhibitors
    Patent number: 11945784
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: April 2, 2024
    Assignee: Cornell University
    Inventors: Joseph P. Vacca, Sarah Elizabeth Bettigole
  • IRE1 SMALL MOLECULE INHIBITORS
    Publication number: 20230271935
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Application
    Filed: February 28, 2023
    Publication date: August 31, 2023
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • IRE1 small molecule inhibitors
    Patent number: 11634403
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Grant
    Filed: February 15, 2021
    Date of Patent: April 25, 2023
    Assignee: Cornell University
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • COMBINATION THERAPIES WITH IRE1 SMALL MOLECULE INHIBITORS
    Publication number: 20220265656
    Abstract: Provided herein are methods of using IRE1 small molecule inhibitors in combination therapies for treating cancer in a subject. The IRE1 small molecule inhibitors described herein may be used in combination therapies for treating solid and hematologic cancers.
    Type: Application
    Filed: May 15, 2020
    Publication date: August 25, 2022
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • IRE1 SMALL MOLECULE INHIBITORS
    Publication number: 20220251065
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Application
    Filed: February 15, 2021
    Publication date: August 11, 2022
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • TREATMENT OF FIBROSIS WITH IRE1 SMALL MOLECULE INHIBITORS
    Publication number: 20220227730
    Abstract: Provided herein are methods of using IRE1 small molecule inhibitors in combination therapies for treating fibrosis in a subject.
    Type: Application
    Filed: May 15, 2020
    Publication date: July 21, 2022
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • IRE1 SMALL MOLECULE INHIBITORS
    Publication number: 20220024878
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Application
    Filed: December 2, 2019
    Publication date: January 27, 2022
    Inventors: Joseph P. Vacca et al., Sarah Elizabeth Bettigole
  • IRE1 SMALL MOLECULE INHIBITORS
    Publication number: 20210284628
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Application
    Filed: May 6, 2021
    Publication date: September 16, 2021
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • SMALL MOLECULE IRE1-ALPHA INHIBITORS
    Publication number: 20210238167
    Abstract: Described herein are IRE1? inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds. Exemplary compounds are provided throughout the application.
    Type: Application
    Filed: March 30, 2021
    Publication date: August 5, 2021
    Inventors: Laurie H. Glimcher, Sarah Elizabeth Bettigole, Juan Rodrigo Cubillos-Ruiz, Joseph P. Vacca
  • Small molecule IRE1-? inhibitors
    Patent number: 10988461
    Abstract: Described herein are IRE1? inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds. Exemplary compounds are provided throughout the application.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: April 27, 2021
    Assignee: Cornell University
    Inventors: Laurie H. Glimcher, Sarah Elizabeth Bettigole, Juan Rodrigo Cubillos-Ruiz, Joseph P. Vacca
  • IRE1 small molecule inhibitors
    Patent number: 10961218
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: March 30, 2021
    Assignee: Cornell University
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • IRE1 Small Molecule Inhibitors
    Publication number: 20200392106
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Application
    Filed: July 16, 2020
    Publication date: December 17, 2020
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • SMALL MOLECULE IRE1-ALPHA INHIBITORS
    Publication number: 20190016706
    Abstract: Described herein are IRE1? inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds. Exemplary compounds are provided throughout the application.
    Type: Application
    Filed: August 29, 2018
    Publication date: January 17, 2019
    Inventors: Laurie H. Glimcher, Sarah Elizabeth Bettigole, Juan Rodrigo Cubillos-Ruiz, Joseph P. Vacca
  • Small molecule IRE1-? inhibitors
    Patent number: 10125123
    Abstract: Described herein are IRE1? inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds. Exemplary compounds are provided throughout the application.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: November 13, 2018
    Assignee: CORNELL UNIVERSITY
    Inventors: Laurie H. Glimcher, Sarah Elizabeth Bettigole, Juan Rodrigo Cubillos Ruiz, Joseph P. Vacca
  • SMALL MOLECULE IRE1-ALPHA INHIBITORS
    Publication number: 20170253590
    Abstract: Described herein are IRE1? inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds. Exemplary compounds are provided throughout the application.
    Type: Application
    Filed: March 3, 2017
    Publication date: September 7, 2017
    Inventors: Laurie H. Glimcher, Sarah Elizabeth Bettigole, Juan Rodrigo Cubillos Ruiz, Joseph P. Vacca
  • SMALL MOLECULE IRE1-ALPHA INHIBITORS
    Publication number: 20170252350
    Abstract: Described herein are IRE1? in inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds. Exemplary compounds are provided throughout the application.
    Type: Application
    Filed: March 3, 2017
    Publication date: September 7, 2017
    Inventors: Laurie H. Glimcher, Sarah Elizabeth Bettigole, Juan Rodrigo Cubillos Ruiz