Abstract: The present disclosure relates to IL-34 antibodies, compositions comprising the same, and methods of using the antibodies and or compositions thereof for treating immune-mediated diseases such as neurodegenerative diseases, for example Alzheimer's Disease or a tauopathy disease.

Abstract: An endotracheal tube securement device is disclosed. The device provides a sanitary and secure way to retain aft endotracheal tube. The device employs bite wedges to prevent a patient from biting the endotracheal tube, while providing an unobtrusive, comfortable and secure means for maintaining the endotracheal tube in place. The device is less visually traumatic than current arrangements. The device is small, with little to no facial contact, providing minimal obstruction of the oral cavity for hygiene and clinical management. The device has a first limb and a second limb joined at a junction that forms a rest for the endotracheal tube. There is a tube retainer attached to the tube rest. A first strut protrudes from the first limb to retain a first bite wedge, and a second strut protrudes from the second limb to retain a second bite wedge. A suction feature may also be provided.