Patents by Inventor Sarah Ferber

Sarah Ferber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of transdifferentiation and methods of use thereof
    Patent number: 11617769
    Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: April 4, 2023
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • THREE DIMENSIONAL CLUSTERS OF TRANSDIFFERENTIATED CELLS, COMPOSITIONS AND METHODS THEREOF
    Publication number: 20210171915
    Abstract: The present disclosure provides compositions and methods for providing a cell replacement therapy to treat various diseases, including pancreatic diseases and diabetes. Specifically, the disclosure provides three-dimensional (3D) cell clusters of transdifferentiated insulin producing cells attached to scaffolds, such as a polysaccharide matrix, in order to provide a cell replacement therapy.
    Type: Application
    Filed: March 6, 2019
    Publication date: June 10, 2021
    Applicants: Orgenesis Inc., B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD. AT BEN GURION UNIVERSITY, TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTRE AND SERVICES LTD.
    Inventors: Efrat ASSA KUNIK, Smadar COHEN, Alon MONSONEGO, Sarah FERBER
  • Transdifferentiated cell populations and methods of use thereof
    Patent number: 10975354
    Abstract: Disclosed herein are methods for manufacturing transdifferentiated populations of non-pancreatic human insulin producing cells, and methods for enriching populations of non-pancreatic ?-cells for cells comprising an enriched capacity for transcription factor-induced transdifferentiation into a pancreatic ?-cell phenotype and function.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: April 13, 2021
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • Cell populations, methods of transdifferentiation and methods of use thereof
    Patent number: 10947509
    Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic ?-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: March 16, 2021
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • METHODS OF TRANSDIFFERENTIATION AND METHODS OF USE THEREOF
    Publication number: 20200297777
    Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
    Type: Application
    Filed: April 1, 2020
    Publication date: September 24, 2020
    Applicants: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah FERBER
  • Methods of transdifferentiation and methods of use thereof
    Patent number: 10668107
    Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: June 2, 2020
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • TRANSDIFFERENTIATED CELL POPULATIONS AND METHODS OF USE THEREOF
    Publication number: 20200140825
    Abstract: Disclosed herein are methods for manufacturing transdifferentiated populations of non-pancreatic human insulin producing cells, and methods for enriching populations of non-pancreatic ?-cells for cells comprising an enriched capacity for transcription factor-induced transdifferentiation into a pancreatic ?-cell phenotype and function.
    Type: Application
    Filed: November 7, 2019
    Publication date: May 7, 2020
    Applicants: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah FERBER
  • COMPOSITIONS AND METHODS FOR PROVIDING CELL REPLACEMENT THERAPY
    Publication number: 20200109370
    Abstract: Disclosed is a three-dimensional (3D) cell cluster comprising transdifferentiated adult mammalian non-pancreatic beta cells having a mature pancreatic beta cell phenotype and function and a scaffold, wherein said transdifferentiated cells have an enhanced mature pancreatic beta cell phenotype compared to a 3D cell cluster without a scaffold and to similarly transdifferentiated cells cultured as a two-dimensional (2D) monolayer.
    Type: Application
    Filed: May 27, 2018
    Publication date: April 9, 2020
    Applicants: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah FERBER
  • METHODS OF TRANSDIFFERENTIATION AND METHODS OF USE THEREOF
    Publication number: 20190134097
    Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
    Type: Application
    Filed: November 29, 2018
    Publication date: May 9, 2019
    Applicants: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah FERBER
  • Methods of transdifferentiation and methods of use thereof
    Patent number: 10179151
    Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: January 15, 2019
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • CELL POPULATIONS, METHODS OF TRANSDIFFERENTIATION AND METHODS OF USE THEREOF
    Publication number: 20180340146
    Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic ?-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.
    Type: Application
    Filed: April 25, 2018
    Publication date: November 29, 2018
    Applicants: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah FERBER
  • Cell populations, methods of transdifferentiation and methods of use thereof
    Patent number: 9982236
    Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic ?-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: May 29, 2018
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
    Patent number: 9481894
    Abstract: Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: November 1, 2016
    Assignee: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • METHODS OF TRANSDIFFERENTIATION AND METHODS OF USE THEREOF
    Publication number: 20160220616
    Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
    Type: Application
    Filed: December 30, 2015
    Publication date: August 4, 2016
    Inventor: Sarah Ferber
  • CELL POPULATIONS, METHODS OF TRANSDIFFERENTIATION AND METHODS OF USE THEREOF
    Publication number: 20160130559
    Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic ?-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.
    Type: Application
    Filed: June 13, 2014
    Publication date: May 12, 2016
    Inventor: SARAH FERBER
  • METHODS OF INDUCING REGULATED PANCREATIC HORMONE PRODUCTION IN NON-PANCREATIC ISLET TISSUES
    Publication number: 20150017727
    Abstract: Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production.
    Type: Application
    Filed: July 14, 2014
    Publication date: January 15, 2015
    Inventor: Sarah Ferber
  • Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
    Patent number: 8778899
    Abstract: Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: July 15, 2014
    Inventor: Sarah Ferber
  • Methods of Inducing Regulated Pancreatic Hormone Production in Non-Pancreatic Islet Tissues
    Publication number: 20120329710
    Abstract: Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production.
    Type: Application
    Filed: December 29, 2011
    Publication date: December 27, 2012
    Inventor: Sarah Ferber
  • Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
    Patent number: 8119405
    Abstract: Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: February 21, 2012
    Inventor: Sarah Ferber
  • Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
    Publication number: 20050090465
    Abstract: Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production.
    Type: Application
    Filed: May 12, 2004
    Publication date: April 28, 2005
    Inventor: Sarah Ferber