Patents by Inventor Sarah Gilbert
Sarah Gilbert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11857640Abstract: Recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors are provided. In particular, the an adenovirus vector having a capsid derived from chimpanzee adenovirus AdY25, wherein the capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest are provided.Type: GrantFiled: April 15, 2020Date of Patent: January 2, 2024Assignee: Oxford University Innovation LimitedInventors: Matthew Douglas James Dicks, Matthew Guy Cottingham, Adrian Vivian Sinton Hill, Sarah Gilbert
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Publication number: 20210310027Abstract: The invention relates to methods for generating a recombinant adenovirus comprising a nucleotide sequence encoding a heterologous gene of interest for use as a vaccine comprising the steps of inserting the heterologous gene of interest into the adenovirus genome by recombining terminal protein complexed adenovirus genomic DNA (TPC-Ad gDNA) with a polynucleotide comprising a nucleotide sequence encoding the gene of interest and having 5? and 3? ends that are homologous to the insertion site sequence of the adenovirus genomic DNA in an in vitro recombination reaction, transfecting cells growing in individual vessels with a dilution of the in vitro recombination reaction mixture from (i) such that a number of such individual vessels contain a single cell that is infected by a recombinant adenovirus comprising the nucleotide sequence encoding the heterologous gene of interest, and identifying those individual vessels in which a single cell has been infected by the recombinant adenovirus comprising the nucleotideType: ApplicationFiled: August 30, 2019Publication date: October 7, 2021Inventors: Sarah GILBERT, Susan Jane MORRIS
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Publication number: 20200360533Abstract: Recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors are provided. In particular, the an adenovirus vector having a capsid derived from chimpanzee adenovirus AdY25, wherein the capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest are provided.Type: ApplicationFiled: April 15, 2020Publication date: November 19, 2020Inventors: Matthew Douglas James Dicks, Matthew Guy Cottingham, Adrian Vivian Sinton Hill, Sarah Gilbert
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Patent number: 10646587Abstract: Recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors are provided. In particular, the an adenovirus vector having a capsid derived from chimpanzee adenovirus AdY25, wherein the capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest are provided.Type: GrantFiled: June 20, 2017Date of Patent: May 12, 2020Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Matthew Douglas James Dicks, Matthew Guy Cottingham, Adrian Vivian Sinton Hill, Sarah Gilbert
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Patent number: 10286060Abstract: The invention relates to a composition suitable for inducing a T cell mediated immune response against an influenza virus in a vertebrate, said composition comprising nucleic acid encoding one or more epitopes of one or more internal proteins of influenza virus, wherein said composition comprises nucleic acid encoding at least two said epitopes, at least one epitope being from each of two or more internal proteins of influenza virus. The invention also relates to uses of same and to methods involving same.Type: GrantFiled: October 24, 2014Date of Patent: May 14, 2019Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Sarah Gilbert, Adrian V. S. Hill, Anne Moore
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Patent number: 10124048Abstract: An adenoviral vector comprising a promoter further comprising a fragment of the 5? untranslated region of the CMV IE1 gene including intron A and a nucleic acid sequence encoding a pathogen or tumor antigen for use as a medicament.Type: GrantFiled: April 27, 2015Date of Patent: November 13, 2018Assignee: Oxford University Innovation LimitedInventors: Simon Draper, Arturo Reyes, Saranya Sridhar, Adrian Hill, Sarah Gilbert, Anna Goodman
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Publication number: 20180000966Abstract: Recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors are provided. In particular, the an adenovirus vector having a capsid derived from chimpanzee adenovirus AdY25, wherein the capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest are provided.Type: ApplicationFiled: June 20, 2017Publication date: January 4, 2018Inventors: Matthew Douglas James Dicks, Matthew Guy Cottingham, Adrian Vivian Sinton Hill, Sarah Gilbert
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Patent number: 9714435Abstract: The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors. In particular, the present invention provides an adenovirus vector comprising a capsid derived from chimpanzee adenovirus AdY25, wherein said capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest.Type: GrantFiled: May 25, 2012Date of Patent: July 25, 2017Assignee: OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Matthew Douglas James Dicks, Matthew Guy Cottingham, Adrian Vivian Sinton Hill, Sarah Gilbert
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Publication number: 20150297700Abstract: An adenoviral vector comprising a promoter further comprising a fragment of the 5? untranslated region of the CMV IE1 gene including intron A and a nucleic acid sequence encoding a pathogen or tumour antigen for use as a medicament.Type: ApplicationFiled: April 27, 2015Publication date: October 22, 2015Inventors: Simon Draper, Arturo Reyes, Saranya Sridhar, Adrian Hill, Sarah Gilbert, Anna Goodman
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Patent number: 9017696Abstract: An adenoviral vector comprising a promoter further comprising a fragment of the 5? untranslated region of the CMV IE1 gene including intron A and a nucleic acid sequence encoding a pathogen or tumor antigen for use as a medicament.Type: GrantFiled: April 10, 2008Date of Patent: April 28, 2015Assignee: Isis Innovation LimitedInventors: Simon Draper, Arturo Reyes, Saranya Sridhar, Adrian Hill, Sarah Gilbert, Anna Goodman
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Publication number: 20150110831Abstract: The invention relates to a composition suitable for inducing a T cell mediated immune response against an influenza virus in a vertebrate, said composition comprising nucleic acid encoding one or more epitopes of one or more internal proteins of influenza virus, wherein said composition comprises nucleic acid encoding at least two said epitopes, at least one epitope being from each of two or more internal proteins of influenza virus. The invention also relates to uses of same and to methods involving same.Type: ApplicationFiled: October 24, 2014Publication date: April 23, 2015Inventors: Sarah Gilbert, Adrian V.S. Hill, Anne Moore
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Publication number: 20150044766Abstract: The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors. In particular, the present invention provides an adenovirus vector comprising a capsid derived from chimpanzee adenovirus AdY25, wherein said capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest.Type: ApplicationFiled: May 25, 2012Publication date: February 12, 2015Inventors: Matthew Douglas James Dicks, Matthew Guy Cottingham, Adrian Vivian Sinton Hill, Sarah Gilbert
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Publication number: 20120058138Abstract: An adenoviral vector comprising a promoter further comprising a fragment of the 5? untranslated region of the CMV IE1 gene including intron A and a nucleic acid sequence encoding a pathogen or tumour antigen for use as a medicament.Type: ApplicationFiled: April 10, 2008Publication date: March 8, 2012Inventors: Simon Draper, Arturo Reyes, Saranya Sridhar, Adrian Hill, Sarah Gilbert, Anna Goodman
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Publication number: 20100322896Abstract: This invention relates to the use of a molecular adjuvant to generate an immune response in a host. In particular, the molecular adjuvant may be a TLR signalling pathway component, a co-stimulatory molecule, an NKG2D ligand, IL- or IL-15.Type: ApplicationFiled: October 7, 2008Publication date: December 23, 2010Inventors: Adrian Vivian Sinton Hill, David Wyllie, Karen Colbjorn Larsen, Alexandra Jane Spencer, Matthew Cottingham, Sarah Gilbert
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Publication number: 20100285050Abstract: The invention relates to a composition suitable for inducing a T cell mediated immune response against an influenza virus in a vertebrate, said composition comprising nucleic acid encoding one or more epitopes of one or more internal proteins of influenza virus, wherein said composition comprises nucleic acid encoding at least two said epitopes, at least one epitope being from each of two or more internal proteins of influenza virus. The invention also relates to uses of same and to methods involving same.Type: ApplicationFiled: September 29, 2008Publication date: November 11, 2010Applicant: Isis Innovation LimitedInventors: Sarah Gilbert, Adrian V.S. Hill, Anne Moore
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Publication number: 20050025747Abstract: The present invention relates to a fowlpox virus genome which has modifications in one or more wild-type FPV genes. The present invention also relates to a viral particle comprising such a genome and its use to deliver a nucleotide of interest (NOI) to a target cell. The present invention also relates to vaccination methods, particularly a method which comprises administering a priming composition (which comprises a first non-replicating viral vector) and a boosting composition (which comprises a second non-replicating viral vector) to a subject to treat and/or prevent a disease.Type: ApplicationFiled: May 27, 2004Publication date: February 3, 2005Applicant: Isis Innovation Ltd.Inventors: Stephen Laidlaw, Mike Skinner, Adrian Hill, Sarah Gilbert, Richard Anderson
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Publication number: 20040018177Abstract: There is provided a method of inducing a CD4+ T-cell response against a target antigen, by administering a composition a source of one or more CD4+ epitopes is a non-replicating or replication impaired recombinant poxvirus vector.Type: ApplicationFiled: July 15, 2003Publication date: January 29, 2004Inventors: Adrian V.S. Hill, Helen McShane, Sarah Gilbert, Joerg Schneider
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Patent number: D583706Type: GrantFiled: November 14, 2007Date of Patent: December 30, 2008Inventor: Sarah Gilbert