Patents by Inventor Sarah Hamren

Sarah Hamren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods For Detecting Phosphorylated Alpha-Synuclein
    Publication number: 20230228772
    Abstract: The invention provides methods of detecting alpha-synuclein using a capture antibody and a reporter antibody. The capture antibody binds preferentially to full-length alpha-synuclein phosphorylated at residue 129 (PS129 alpha-synuclein) over unphosphorylated full-length alpha-synuclein. The 11A5 antibody is an example of a suitable capture antibody. The reporter antibody binds to an epitope within residues 40-55 of alpha-synuclein. The 23E8 antibody is an example of such an antibody. Because only a small proportion of alpha-synuclein is phosphorylated high sensitivity of detection below picomolar is advantageous.
    Type: Application
    Filed: January 26, 2023
    Publication date: July 20, 2023
    Inventors: Robin BARBOUR, Lynn R. ZIESKE, Sarah HAMREN
  • Methods For Detecting Phosphorylated Alpha-Synuclein
    Publication number: 20210165000
    Abstract: The invention provides methods of detecting alpha-synuclein using a capture antibody and a reporter antibody. The capture antibody binds preferentially to full-length alpha-synuclein phosphorylated at residue 129 (PS129 alpha-synuclein) over unphosphorylated full-length alpha-synuclein. The 11A5 antibody is an example of a suitable capture antibody. The reporter antibody binds to an epitope within residues 40-55 of alpha-synuclein. The 23E8 antibody is an example of such an antibody. Because only a small proportion of alpha-synuclein is phosphorylated high sensitivity of detection below picomolar is advantageous.
    Type: Application
    Filed: October 30, 2020
    Publication date: June 3, 2021
    Inventors: Robin Barbour, Lynn R. Zieske, Sarah Hamren
  • Methods for detecting phosphorylated alpha-synuclein
    Patent number: 10852309
    Abstract: The invention provides methods of detecting alpha-synuclein using a capture antibody and a reporter antibody. The capture antibody binds preferentially to full-length alpha-synuclein phosphorylated at residue 129 (PS129 alpha-synuclein) over unphosphorylated full-length alpha-synuclein. The 11A5 antibody is an example of a suitable capture antibody. The reporter antibody binds to an epitope within residues 40-55 of alpha-synuclein. The 23E8 antibody is an example of such an antibody. Because only a small proportion of alpha-synuclein is phosphorylated high sensitivity of detection below picomolar is advantageous.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: December 1, 2020
    Assignee: PROTHENA BIOSCIENCES LIMITED
    Inventors: Robin Barbour, Lynn R. Zieske, Sarah Hamren