Patents by Inventor Sarah J. Cox

Sarah J. Cox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymer-based lipid nanodiscs and macrodiscs
    Patent number: 11092605
    Abstract: The disclosure provides a lipid nanodisc including a lipid bilayer having two opposing hydrophilic faces and a hydrophobic edge between the hydrophilic faces, and a copolymer encircling the hydrophobic edge of the lipid bilayer, the copolymer including a first monomeric unit including a pendant aromatic group, and a second monomeric unit including a pendant hydrophilic group, wherein the first monomeric unit and the second monomeric unit are present in the copolymer is a molar ratio ranging from 1:1 to 3:1 for the first monomeric unit:the second monomeric unit. The disclosure further provides a method of making the polymer-based lipid nanodiscs of the disclosure and methods of characterizing membrane proteins using the polymer-based lipid nanodiscs of the disclosure.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: August 17, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Ayyalusamy Ramamoorthy, Thirupathi Ravula, Nathaniel Z. Hardin, Sarah J. Cox
  • Polymer-Based Lipid Nanodiscs And Macrodiscs
    Publication number: 20190154698
    Abstract: The disclosure provides a lipid nanodisc including a lipid bilayer having two opposing hydrophilic faces and a hydrophobic edge between the hydrophilic faces, and a copolymer encircling the hydrophobic edge of the lipid bilayer, the copolymer including a first monomeric unit including a pendant aromatic group, and a second monomeric unit including a pendant hydrophilic group, wherein the first monomeric unit and the second monomeric unit are present in the copolymer is a molar ratio ranging from 1:1 to 3:1 for the first monomeric unit:the second monomeric unit. The disclosure further provides a method of making the polymer-based lipid nanodiscs of the disclosure and methods of characterizing membrane proteins using the polymer-based lipid nanodiscs of the disclosure.
    Type: Application
    Filed: November 21, 2018
    Publication date: May 23, 2019
    Inventors: Ayyalusamy Ramamoorthy, Venkata Sudheer Ramadugu, Thirupathi Ravula, Nathaniel Z. Hardin, Sarah J. Cox