Patents by Inventor Sarah M. Assmann

Sarah M. Assmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sensitive and Accurate Genome-wide Profiling of RNA Structure In Vivo
    Publication number: 20220267838
    Abstract: The invention provides improved methods for determining the structure of RNA molecules with increased sensitivity, improved data quality, reduced ligation bias, and improved read coverage, incorporating the removal of undesired bi-products and ligation using a fast, efficient, and low-sequence bias hybridization-ligation method.
    Type: Application
    Filed: November 13, 2018
    Publication date: August 25, 2022
    Inventors: Philip C. Bevilacqua, Sarah M. Assmann, Zhao Su, Laura Ritchey, David Mitchell
  • Low sequence bias single-stranded DNA ligation
    Patent number: 10640828
    Abstract: The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin) and a 3?-overhang region such that the overhang is able to hybridize to nucleotides present in the 3? end of the acceptor molecule.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: May 5, 2020
    Assignee: The Penn State Research Foundation
    Inventors: Philip C. Bevilacqua, Sarah M. Assmann, Yiliang Ding, Chun Kit Kwok
  • Low Sequence Bias Single-Stranded DNA Ligation
    Publication number: 20180030494
    Abstract: The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin) and a 3?-overhang region such that the overhang is able to hybridize to nucleotides present in the 3? end of the acceptor molecule.
    Type: Application
    Filed: October 17, 2017
    Publication date: February 1, 2018
    Inventors: Philip C. Bevilacqua, Sarah M. Assmann, Yiliang Ding, Chun Kit Kwok
  • Low sequence bias single-stranded DNA ligation
    Patent number: 9816120
    Abstract: The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin) and a 3?-overhang region such that the overhang is able to hybridize to nucleotides present in the 3? end of the acceptor molecule.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: November 14, 2017
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Philip C. Bevilacqua, Sarah M. Assmann, Yiliang Ding, Chun Kit Kwok
  • Low Sequence Bias Single-Stranded DNA Ligation
    Publication number: 20140193860
    Abstract: The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin) and a 3?-overhang region such that the overhang is able to hybridize to nucleotides present in the 3? end of the acceptor molecule.
    Type: Application
    Filed: January 9, 2014
    Publication date: July 10, 2014
    Applicant: The Penn State Research Foundation
    Inventors: Philip C. Bevilacqua, Sarah M. Assmann, Yiliang Ding, Chun Kit Kwok
  • METHODS AND COMPOSITIONS RELATING TO CONROLLED INDUCTION OF PLANT SENESCENCE
    Publication number: 20110191894
    Abstract: Methods and compositions for promoting senescence in plants are provided. Methods and compositions for promoting senescence in plants by increased expression of an exogenous or endogenous abscisic-acid-activated protein kinase-interacting protein, AKIP. In specific embodiments, transgenic plants are provided expressing increased abscisic-acid-activated protein kinase-interacting protein, AKIP, during the developmental stage of senescence, thereby promoting enhanced plant senescence.
    Type: Application
    Filed: August 4, 2010
    Publication date: August 4, 2011
    Applicant: The Penn State Research Foundation
    Inventors: Sarah M. Assmann, Cha Young Kim, Jerome Bove, John Kuk Na
  • Compositions and methods for regulating abscisic acid-induced closure of plant stomata
    Publication number: 20080163391
    Abstract: A novel gene, AAPK, is disclosed. Loss of function of the protein encoded by AAPK is associated with reduced sensitivity to abscisic acid-induced stomatal closure in plants. Also disclosed are transgenic plants and mutants having altered sensitivity to abscisic acid-mediated transpiration and other desirable agronomic features. The regulation of transpiration provided by the present invention is different from that of previously described mechanisms to control transpiration in plants.
    Type: Application
    Filed: March 26, 2007
    Publication date: July 3, 2008
    Inventors: Sarah M. Assmann, Jiaxu Li
  • Compositions and methods for regulating abscisic acid-induced closure of plant stomata
    Patent number: 7211436
    Abstract: A novel gene, AAPK, is disclosed. Loss of function of the protein encoded by AAPK is associated with reduced sensitivity to abscisic acid-induced stomatal closure in plants. Also disclosed are transgenic plants and mutants having altered sensitivity to abscisic acid-mediated transpiration and other desirable agronomic features. The regulation of transpiration provided by the present invention is different from that of previously described mechanisms to control transpiration in plants.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: May 1, 2007
    Assignee: The Penn State Research Foundation
    Inventors: Sarah M. Assmann, Jiaxu Li