Patents by Inventor Sarah McFarland

Sarah McFarland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Improved Filamentous Fungal Host Cells
    Publication number: 20220025422
    Abstract: The present invention relates to an isolated variant Ire1 polypeptide, comprising (a) an amino acid substitution at position 153 of the Trichoderma reesei Ire1 polypeptide of SEQ ID NO: 2; or (b) an amino acid substitution at a position corresponding to position 153 of the Trichoderma reesei Ire1 of SEQ ID NO: 2 and has at least 70%, but less than 100%, sequence identity to the amino acid sequence of SEQ ID NO: 2. The present invention also relates to a recombinant filamentous fungal host cell comprising the mutated ire1 gene encoding the variant Ire1 polypeptide for producing a secreted heterologous polypeptide of interest, a method for producing the secreted heterologous polypeptide of interest in the recombinant filamentous fungal host cell, and a method of improving the productivity or yield of the secreted heterologous polypeptide of interest in the recombinant filamentous fungal host cell.
    Type: Application
    Filed: November 26, 2019
    Publication date: January 27, 2022
    Inventors: Suchindra Maiyuran, Sarah McFarland
  • Recombinant microorganisms for production C4-dicarboxylic acids
    Patent number: 8663956
    Abstract: Provided herein are host cells comprising carbonic anhydrase activity, wherein the cells are capable of producing C4-dicarboxylic acid. Also provided are methods of producing C4-dicarboxylic acid comprising (a) cultivating the host cells having carbonic anhydrase activity in a medium under suitable conditions to produce C4-dicarboxylic acid; and (b) recovering the C4-dicarboxylic acid.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: March 4, 2014
    Assignee: Novozymes, Inc.
    Inventors: Sarah McFarland, Stephen Brown, Sheryl Luttringer
  • C4 dicarboxylic acid production in filamentous fungi
    Patent number: 8617859
    Abstract: The present invention relates to methods of producing C4 dicarboxylic acids, such as malic acid, comprising: (a) cultivating a host cell comprising a polynucleotide encoding a C4 dicarboxylic acid transporter; and (b) recovering the C4 dicarboxylic acid. The present invention also relates to methods for increasing C4 dicarboxylic acid production, as well as host cells comprising the polynucleotides.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: December 31, 2013
    Assignee: Novozymes, Inc.
    Inventors: Sarah McFarland, Amanda Fischer
  • C4 DICARBOXYLIC ACID PRODUCTION IN FILAMENTOUS FUNGI
    Publication number: 20130089902
    Abstract: The present invention relates to methods of producing C4 dicarboxylic acids, such as malic acid, comprising: (a) cultivating a host cell comprising a polynucleotide encoding a C4 dicarboxylic acid transporter; and (b) recovering the C4 dicarboxylic acid. The present invention also relates to methods for increasing C4 dicarboxylic acid production, as well as host cells comprising the polynucleotides.
    Type: Application
    Filed: June 2, 2011
    Publication date: April 11, 2013
    Applicant: Novozymes, Inc.
    Inventors: Sarah McFarland, Amanda Fischer
  • Recombinant Microorganisms for Production C4-Dicarboxylic Acids
    Publication number: 20130059353
    Abstract: Provided herein are host cells comprising carbonic anhydrase activity, wherein the cells are capable of producing C4-dicarboxylic acid. Also provided are methods of producing C4-dicarboxylic acid comprising (a) cultivating the host cells having carbonic anhydrase activity in a medium under suitable conditions to produce C4-dicarboxylic acid; and (b) recovering the C4-dicarboxylic acid.
    Type: Application
    Filed: August 17, 2012
    Publication date: March 7, 2013
    Applicant: NOVOZYMES, INC.
    Inventors: Sarah McFarland, Stephen Brown, Sheryl Luttringer