Patents by Inventor Sarah Milne

Sarah Milne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prevention of N-terminal truncation in IgG light chains
    Patent number: 10618952
    Abstract: We discovered that recombinant antibody light chains having a murine secretory leader sequence and an SYE motif at the N-terminus are truncated during post-translational processing. This disclosure provides two protein engineering solutions: to alter the SYE amino acid sequence of the Lc N-terminus to other alternatives; or to change the secretory leader peptide sequence. We have shown that both of these solutions are effective for preventing N-terminal light chain truncation.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: April 14, 2020
    Assignee: MedImmune Limited
    Inventors: Nicholas J. Bond, Suzanne J. Gibson, Diane Hatton, Daniel R. Higazi, Sarah Milne, Mariana Alessia Sheriff
  • PREVENTION OF N-TERMINAL TRUNCATION IN IGG LIGHT CHAINS
    Publication number: 20180251525
    Abstract: We discovered that recombinant antibody light chains having a murine secretory leader sequence and an SYE motif at the N-terminus are truncated during post-translational processing. This disclosure provides two protein engineering solutions: to alter the SYE amino acid sequence of the Lc N-terminus to other alternatives; or to change the secretory leader peptide sequence. We have shown that both of these solutions are effective for preventing N-terminal light chain truncation.
    Type: Application
    Filed: October 28, 2016
    Publication date: September 6, 2018
    Inventors: Nicholas J. Bond, Suzanne J. Gibson, Diane Hatton, Daniel R. Higazi, Sarah Milne, Mariana Alessia Sheriff