Patents by Inventor Sarah P. Thayer

Sarah P. Thayer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method For Inducing Beta Cell Neogenesis From Epithelial Cells
    Publication number: 20090305987
    Abstract: The invention provides a method of inducing ?-cell neogenesis from epithelial cells. The method includes the step of exposing epithelial cells that have a disrupted G1-S cell cycle transition to a hedgehog protein in an amount effective to stimulate ?-cell neogenesis from the epithelial cells. Cells resulting from the method are insulin-positive and express pancreatic progenitor cell markers including Pdx-1 and ngn3. ?-cell population expansion is observed when the method is carried out in either in vitro or in vivo settings.
    Type: Application
    Filed: May 18, 2009
    Publication date: December 10, 2009
    Applicant: The General Hospital Corporation
    Inventors: Sarah P. Thayer, Jennifer LaFemina Fowler, Andrew L. Warshaw, Carlos Fernandez-del Castillo