Abstract: Disclosed herein is an endotracheal tube cuff having a first layer, a second layer, and one or more sensors in a space between the first and second layers. The one or more sensors are operable to measure pressure between the endotracheal tube cuff and a tracheal wall of a patient. Also disclosed herein are methods of detecting a leak and preventing ischemia using the endotracheal tube cuff.

Abstract: A hot-fill plastic container has a polygonal (e.g., hex-shape) sidewall portion and a plurality of panels in a sidewall portion that are configured to flex in response to an internal vacuum pressure. Further, in embodiments, the container may be suitable for hot filling while having a container weight that may be 20% to 30%, or even higher percentages, below current comparative conventional weights for a plastic container that is intended to hold an equivalent volume of contents. In embodiments, the panels may be configured, e.g., adjusted or “tuned,” to provide a desired (e.g., reduced or extended) shelf-life.