Patents by Inventor Sarah R. Wayland
Sarah R. Wayland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8552173Abstract: The present invention relates to compositions useful as probes and in other applications and methods of their use. In some embodiments, nucleotides are prepared and functionalized with dyes. In some embodiments a first molecule is functionalized with an alkynyl group, a second molecule is functionalized with an azide group, and said first and second molecules are mixed under conditions to form a conjugate with a 1,2,3-triazol group. In further embodiments, a nucleotide is functionalized with an alkynyl group, a dye is functionalized with an azide group, and mixing the nucleotide and the dye forms a conjugate capable of emitting light.Type: GrantFiled: August 22, 2011Date of Patent: October 8, 2013Assignee: Third Wave Technologies, Inc.Inventors: Zbigniev Skrzypczynski, Sarah R. Wayland
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Publication number: 20120010395Abstract: The present invention relates to compositions useful as probes and in other applications and methods of their use. In some embodiments, nucleotides are prepared and functionalized with dyes. In some embodiments a first molecule is functionalized with an alkynyl group, a second molecule is functionalized with an azide group, and said first and second molecules are mixed under conditions to form a conjugate with a 1,2,3-triazol group. In further embodiments, a nucleotide is functionalized with an alkynyl group, a dye is functionalized with an azide group, and mixing the nucleotide and the dye forms a conjugate capable of emitting light.Type: ApplicationFiled: August 22, 2011Publication date: January 12, 2012Applicant: THIRD WAVE TECHNOLOGIES, INC.Inventors: Zbigniew Skrzypczynski, Sarah R. Wayland
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Patent number: 8003771Abstract: The present invention relates to compositions useful as probes and in other applications and methods of their use. In some embodiments, nucleotides are prepared and functionalized with dyes. In some embodiments a first molecule is functionalized with an alkynyl group, a second molecule is functionalized with an azide group, and said first and second molecules are mixed under conditions to form a conjugate with a 1,2,3-triazol group. In further embodiments, a nucleotide is functionalized with an alkynyl group, a dye is functionalized with an azide group, and mixing the nucleotide and the dye forms a conjugate capable of emitting light.Type: GrantFiled: March 1, 2010Date of Patent: August 23, 2011Assignee: Third Wave Technologies, Inc.Inventors: Zbigniew Skrzypczynski, Sarah R Wayland
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Publication number: 20100152431Abstract: The present invention relates to compositions useful as probes and in other applications and methods of their use. In some embodiments, nucleotides are prepared and functionalized with dyes. In some embodiments a first molecule is functionalized with an alkynyl group, a second molecule is functionalized with an azide group, and said first and second molecules are mixed under conditions to form a conjugate with a 1,2,3-triazol group. In further embodiments, a nucleotide is functionalized with an alkynyl group, a dye is functionalized with an azide group, and mixing the nucleotide and the dye forms a conjugate capable of emitting light.Type: ApplicationFiled: March 1, 2010Publication date: June 17, 2010Applicant: THIRD WAVE TECHNOLOGIES, INC.Inventors: Zbigniew Skrzypczynski, Sarah R. Wayland
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Patent number: 7678542Abstract: The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge of the material. The present invention further provides methods for separating and characterizing molecules based on the charge differentials between modified and unmodified materials.Type: GrantFiled: June 3, 2008Date of Patent: March 16, 2010Assignee: Third Wave Technologies, Inc.Inventors: Victor Lyamichev, Zbigniev Skrzypczynski, Hatim T. Allawi, Sarah R. Wayland, Tsetska Y. Takova, Bruce P. Neri, James R. Prudent, Jeff G. Hall
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Patent number: 7674924Abstract: The present invention relates to compositions useful as probes and in other applications and methods of their use. In some embodiments, nucleotides are prepared and functionalized with dyes. In some embodiments a first molecule is functionalized with an alkynyl group, a second molecule is functionalized with an azide group, and said first and second molecules are mixed under conditions to form a conjugate with a 1,2,3-triazol group. In further embodiments, a nucleotide is functionalized with an alkynyl group, a dye is functionalized with an azide group, and mixing the nucleotide and the dye forms a conjugate capable of emitting light.Type: GrantFiled: May 22, 2007Date of Patent: March 9, 2010Assignee: Third Wave Technologies, Inc.Inventors: Zbigniev Skrzypczynski, Sarah R. Wayland
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Publication number: 20090078574Abstract: The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge of the material. The present invention further provides methods for separating and characterizing molecules based on the charge differentials between modified and unmodified materials.Type: ApplicationFiled: June 3, 2008Publication date: March 26, 2009Applicant: THIRD WAVE TECHNOLOGIES, INC.Inventors: Victor Lyamichev, Zbigniev Skrzypczynski, Hatim T. Allawi, Sarah R. Wayland, Tsetska Y. Takova, Bruce P. Neri, James R. Prudent, Jeff G. Hall
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Patent number: 7462451Abstract: The present invention relates to compositions and methods for the preparation of modified nucleic acids. In particular, the present invention provides novel reagents and chemistries for the generation of linkers, modified phosphoramidites, and modified solid supports.Type: GrantFiled: April 26, 2005Date of Patent: December 9, 2008Assignee: Third Wave Technologies, Inc.Inventors: Zbigniev Skrzypczynski, Sarah R. Wayland
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Publication number: 20080182980Abstract: The present invention relates to compositions and methods for the preparation of modified nucleic acids. In particular, the present invention provides novel reagents and chemistries for the generation of linkers and modified phosphoramidates.Type: ApplicationFiled: November 20, 2007Publication date: July 31, 2008Applicant: THIRD WAVE TECHNOLOGIES, INC.Inventors: Zbigniev Skrzypczynski, Sarah R. Wayland
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Patent number: 7384746Abstract: The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge of the material. The present invention further provides methods for separating and characterizing molecules based on the charge differentials between modified and unmodified materials.Type: GrantFiled: June 23, 2004Date of Patent: June 10, 2008Assignee: Third Wave Technologies, Inc.Inventors: Victor Lyamichev, Zbigniev Skrzypczynski, Hatim T. Allawi, Sarah R. Wayland, Tsetska Y. Takova, Bruce P. Neri, James R. Prudent, Jeff G. Hall
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Patent number: 7297780Abstract: The present invention relates to compositions and methods for the preparation of modified nucleic acids. In particular, the present invention provides novel reagents and chemistries for the generation of linkers and modified phosphoramidates.Type: GrantFiled: January 6, 2004Date of Patent: November 20, 2007Inventors: Zbigniev Skrzypczynski, Sarah R. Wayland
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Publication number: 20040219576Abstract: The present invention relates to compositions and methods for the preparation of modified nucleic acids. In particular, the present invention provides novel reagents and chemistries for the generation of linkers and modified phosphoramidates.Type: ApplicationFiled: January 6, 2004Publication date: November 4, 2004Applicant: Third Wave Technologies, Inc.Inventors: Zbigniev Skrzypczynski, Sarah R. Wayland
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Patent number: 6780982Abstract: The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge of the material. The present invention further provides methods for separating and characterizing molecules based on the charge differentials between modified and unmodified materials.Type: GrantFiled: February 6, 2001Date of Patent: August 24, 2004Assignee: Third Wave Technologies, Inc.Inventors: Victor Lyamichev, Zbigniew Skrzpczynski, Hatim T. Allawi, Sarah R. Wayland, Tsetska Takova, Bruce P. Neri
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Publication number: 20020128465Abstract: The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or decrease the net charge of the material. The present invention further provides methods for separating and characterizing molecules based on the charge differentials between modified and unmodified materials.Type: ApplicationFiled: February 6, 2001Publication date: September 12, 2002Applicant: Third Wave Technologies, Inc.Inventors: Victor Lyamichev, Zbigniew Skrzpczynski, Hatim T. Allawi, Sarah R. Wayland, Tsetska Takova, Bruce P. Neri