Abstract: An intravaginal culture device includes an outer housing configured for vaginal insertion. The outer housing includes an upper portion that removably couples with a lower portion. A first inner vessel is located at the upper portion and is configured to house a first plurality of embryos. A second inner vessel is located at the lower portion and is configured to house a second plurality of embryos.

Abstract: RNA polymerase I (Pol I) is a dedicated polymerase for the transcription of the 47S ribosomal RNA precursor subsequently processed into the mature 5.8S, 18S and 28S ribosomal RNAs and assembled into ribosomes in the nucleolus. Pol I activity is commonly deregulated in human cancers. Based on the discovery of lead molecule BMH-21, a series of pyridoquinazolinecarboxamides were synthesized as inhibitors of Pol I and activators of the destruction of RPA194, the Pol I large catalytic subunit protein. The present invention identifies a set of bioactive compounds, including purified stereoisomers, that potently cause RPA194 degradation that function in a tightly constrained chemical space. Pharmaceutical compositions comprising these compounds and their uses in cancer and other Pol I related diseases is also provided.

Abstract: A carrier device for removably coupling to a vehicle hitch for supporting a carrier is provided. The carrier device includes a hitch connector and a riser support coupled to the hitch connector. A cross support is coupled to the riser support and configured to move between a first position and a second position. The cross support includes a pair of arms configured to couple to the carrier.