Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: An apparatus for controlling precursor flow. The apparatus may include a processor; and a memory unit coupled to the processor, including a flux control routine. The flux control routine may be operative on the processor to monitor the precursor flow and may include a flux calculation processor to determine a precursor flux value based upon a change in detected signal intensity received from a cell of a gas delivery system to deliver a precursor.

Abstract: An apparatus for controlling precursor flow. The apparatus may include a processor; and a memory unit coupled to the processor, including a flux control routine. The flux control routine may be operative on the processor to monitor the precursor flow and may include a flux calculation processor to determine a precursor flux value based upon a change in detected signal intensity received from a cell of a gas delivery system to deliver a precursor.

Abstract: Systems, methods, and computer program products relating to clustering unstructured data. A set of unstructured documents is tokenized to produce a plurality of tokens. A frequency at which terms appear in the plurality of tokens is analyzed, to generate a vocabulary of terms. A vocabulary indices matrix is generated based on the generated vocabulary of terms. The matrix relates to the set of unstructured documents. A plurality of rows in the vocabulary indices matrix are matched to generate a plurality of clusters for the set of unstructured documents.

Abstract: An apparatus for controlling precursor flow. The apparatus may include a processor; and a memory unit coupled to the processor, including a flux control routine. The flux control routine may be operative on the processor to monitor the precursor flow and may include a flux calculation processor to determine a precursor flux value based upon a change in detected signal intensity received from a cell of a gas delivery system to deliver a precursor.

Abstract: An apparatus for controlling precursor flow. The apparatus may include a processor; and a memory unit coupled to the processor, including a flux control routine. The flux control routine may be operative on the processor to monitor the precursor flow and may include a flux calculation processor to determine a precursor flux value based upon a change in detected signal intensity received from a cell of a gas delivery system to deliver a precursor.

Abstract: Systems, methods, and computer program products relating to clustering unstructured data. A set of unstructured documents is tokenized to produce a plurality of tokens. A frequency at which terms appear in the plurality of tokens is analyzed, to generate a vocabulary of terms. A vocabulary indices matrix is generated based on the generated vocabulary of terms. The matrix relates to the set of unstructured documents. A plurality of rows in the vocabulary indices matrix are matched to generate a plurality of clusters for the set of unstructured documents.

Abstract: An apparatus for controlling precursor flow. The apparatus may include a processor; and a memory unit coupled to the processor, including a flux control routine. The flux control routine may be operative on the processor to monitor the precursor flow and may include a flux calculation processor to determine a precursor flux value based upon a change in detected signal intensity received from a cell of a gas delivery system to deliver a precursor.

Abstract: The disclosed systems and methods provide security for goods during transport and can help generate necessary customs and other government forms based on the requirements for each country or jurisdiction into which the cargo shipment travels during transport. Declarations forms customized to the cargo shipment and based on the individual requirements of the countries can be generated along with guides to help inspect the goods, provide a secure chain of custody for the goods, and manage cargo with multiple shipments.

Abstract: The present invention provides a method, system, and computer program product for improved functionality within an instant messaging system. A user's identification is authorized when the user logs on to a current device. A determination that the user is logged on to another, original, device is made. Applicable instant messaging user preferences from the original device are copied and applied to the current device.

Abstract: A computer controlled interactive television system comprising receiving apparatus for and storing a transmitted data stream representative of television programs of defined duration originally broadcast at defined times comprising apparatus for receiving and storing the transmitted data, a television display in combination with apparatus enabling a user to select the presentation of one of said stored television programs on the television display and apparatus responsive to a user selection of a stored program for presenting the selected television program on the television display. This is representative of a standard PVR or DVR operation.

Abstract: Methods are provided for treating an infection by Gram-positive bacteria in a mammal, by administering to the mammal an effective amount of a compound that binds noncovalently in the minor groove of duplex DNA, the compound being identified by a number of DNA binding parameters and, in many instances, being a polyaromatic compound.