Abstract: The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: In an indirect interaction input device, z-information can be considered in defining a user interaction model for the device. Any measurement of displacement in a z-direction can be used, if such information is available from the input device. The pressure data can be used to define states of interaction, with transitions between these states determined by various thresholds. The device can provide raw or normalized data, and can provide state information or data defining its thresholds that specify state transitions. This information can be provided as an attribute of a contact point provided by the device. Data can be normalized across various similar devices. Applications can use the raw pressure data from the device for their own purposes, or rely on the device itself or host operating system software to interpret the pressure data according to thresholds and states.

Abstract: In an indirect interaction input device, z-information can be considered in defining a user interaction model for the device. Any measurement of displacement in a z-direction can be used, if such information is available from the input device. The pressure data can be used to define states of interaction, with transitions between these states determined by various thresholds. The device can provide raw or normalized data, and can provide state information or data defining its thresholds that specify state transitions. This information can be provided as an attribute of a contact point provided by the device. Data can be normalized across various similar devices. Applications can use the raw pressure data from the device for their own purposes, or rely on the device itself or host operating system software to interpret the pressure data according to thresholds and states.

Abstract: Systems and methods authenticate a device to operate within an enterprise system with an enterprise policy. An agent, installed on the device, analyzes the device to determine profile information of the device. The determined profile information is sent to a type 2 super peer that verifies whether the profile information conforms to the enterprise policy. If the profile information conforms to the enterprise policy, an agent trust credential is generated, within the type 2 super peer, for the agent, based upon the profile information, and issued to the agent. Authenticity of the device is verified based upon the agent trust credential. If the device is authenticated, communications with the device are permitted. If the device is not authenticated, communications with the device is prevented. In another embodiment, a method restores a device to conform to a system policy. A snapshot of critical components of the device is taken while the device is in compliance with the system policy.

Abstract: A computer system receives and stores information relating to actual past financial results, expected future trends in financial results, and anticipated effects of initiatives intended to change the expected trends. The system processes the information and generates first and second forecast data. The first forecast data indicates forecast financial results without considering the effects of the initiative. The second forecast data indicates forecast financial results that reflect expected results of the initiatives. The first and second forecast data are stored and subsequently displayed to users.

Abstract: Systems and methods authenticate a device to operate within an enterprise system with an enterprise policy. An agent, installed on the device, analyzes the device to determine profile information of the device. The determined profile information is sent to a type 2 super peer that verifies whether the profile information conforms to the enterprise policy. If the profile information conforms to the enterprise policy, an agent trust credential is generated, within the type 2 super peer, for the agent, based upon the profile information, and issued to the agent. Authenticity of the device is verified based upon the agent trust credential. If the device is authenticated, communications with the device are permitted. If the device is not authenticated, communications with the device is prevented. In another embodiment, a method restores a device to conform to a system policy. A snapshot of critical components of the device is taken while the device is in compliance with the system policy.

Abstract: A system and method protect an electronic network. One or more agents are installed within the electronic network and perform an initial assessment of the electronic network to determine normal activity. The electronic network is then monitored for abnormal activity using the agents, and protected by blocking the abnormal activity using the agents.

Abstract: An apparatus and method for non-intrusive collection of off-gas data in a steelmaking furnace includes structure and steps for transmitting a laser beam through the off-gas produced by a steelmaking furnace, for controlling the transmitting to repeatedly scan the laser beam through a plurality of wavelengths in its tuning range, and for detecting the laser beam transmitted through the off-gas and converting the detected laser beam to an electrical signal. The electrical signal is processed to determine characteristics of the off-gas that are used to analyze and/or control the steelmaking process.