Abstract: Disclosed are prodrugs of anthracyclines (such as doxorubicin) and derivatives thereof that are selectively cleaved and activated by fibroblast activating protein (FAP). The prodrugs are useful for targeted delivery of “warhead” anthracycline or anthracycline derivative to FAP-expressing tissues, including cancer (e.g., solid tumors). Also provided are pharmaceutical compounds comprising the prodrugs, as well as methods of using the prodrugs to treat a disorder characterized by FAP upregulation, e.g., cancer undesirable fibrosis and undesirable inflammation.

Abstract: The present application provides sulfonyl amide compounds, which are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

Abstract: A method, system, and computer program product are provided. During creating a document by a creation module, the content of the document is analyzed. Sources used while creating the document are analyzed using NLP, sentiment analysis, tone analysis, speech-to-text, and visual recognition. The sources are associated with a location in the document. Sources are filtered out based on a degree of correlation to the document. Sources are linked to the document where a correlation is found between the document and the sources. The linked sources are stored in a database for recall. During a presentation of the document, upon receiving a question, the question is analyzed to determine a relevant logical section of the document, and the relevant sources are retrieved.

Abstract: A real-time performance management may be used for cycling. A first computing device retrieves profile data related to a cyclist. The first computing device receives sensor readings from one or more sensors. A first sensor of the one or more sensors detects cyclist tilt. Profile data and the sensor readings from the one or more sensors determine cyclist status. A notification based on the determined cyclist status communicates to a user.

Abstract: In an apparatus for hazardous chemical detection in a microwave oven, a microwave oven comprises an electromagnetic wave shielding material, at least one chemiresistor, a microcontroller, and a digital display, wherein the at least one chemiresistor is overlaid by the electromagnetic wave shielding material, and the microcontroller is electronically coupled to the digital display. In an approach to detect the release of a hazardous chemical during a cooking cycle in a microwave oven, a processor receives a reading from at least one chemiresistor, wherein the at least one chemiresistor is configured to detect a chemical. A processor determines whether a pre-set threshold is met. In response to the pre-set threshold being met, a processor sends an alert.

Abstract: In one example implementation according to aspects of the present disclosure, a computer-implemented method includes receiving a list of items to be purchased by a user. The method further includes performing an analysis of the list of items based at least in part on a cost for each item of the list of items at each of a plurality of stores, a distance of travel to each of the plurality of stores, and promotional discounts for one or more of the items of the list of items at each of the plurality of stores. The method further includes generating a table of recommendations based on the analysis. Each recommendation of the table of recommendations can include a description, a total travel distance, and a total cost.

Abstract: A method, system, and computer program product are provided. During creating a document by a creation module, the content of the document is analyzed. Sources used while creating the document are analyzed using NLP, sentiment analysis, tone analysis, speech-to-text, and visual recognition. The sources are associated with a location in the document. Sources are filtered out based on a degree of correlation to the document. Sources are linked to the document where a correlation is found between the document and the sources. The linked sources are stored in a database for recall. During a presentation of the document, upon receiving a question, the question is analyzed to determine a relevant logical section of the document, and the relevant sources are retrieved.

Abstract: Embodiments described herein are directed to computer-implemented methods, systems, and computer program products for calculating a metric using natural language processing tokens. A non-limiting example of the computer-implemented method includes parsing, by a processing device, user content using a natural language processing technique to extract tokens. The method further includes filtering, by the processing device, the tokens relating to a natural language processing criterion. The method further includes calculating, by the processing device, a metric based at least in part on the filtered tokens. The method further includes determining, by the processing device, whether to take an action by applying the metric to a set of rules. The method further includes taking the action responsive to determining to take the action.

Abstract: Embodiments described herein are directed to computer-implemented methods, systems, and computer program products for calculating a metric using natural language processing tokens. A non-limiting example of the computer-implemented method includes parsing, by a processing device, user content using a natural language processing technique to extract tokens. The method further includes filtering, by the processing device, the tokens relating to a natural language processing criterion. The method further includes calculating, by the processing device, a metric based at least in part on the filtered tokens. The method further includes determining, by the processing device, whether to take an action by applying the metric to a set of rules. The method further includes taking the action responsive to determining to take the action.

Abstract: In an apparatus for hazardous chemical detection in a microwave oven, a microwave oven comprises an electromagnetic wave shielding material, at least one chemiresistor, a microcontroller, and a digital display, wherein the at least one chemiresistor is overlaid by the electromagnetic wave shielding material, and the microcontroller is electronically coupled to the digital display. In an approach to detect the release of a hazardous chemical during a cooking cycle in a microwave oven, a processor receives a reading from at least one chemiresistor, wherein the at least one chemiresistor is configured to detect a chemical. A processor determines whether a pre-set threshold is met. In response to the pre-set threshold being met, a processor sends an alert.

Abstract: Methods, systems, and computer program products for providing reminders to users based on voice recognition are provided. Aspects include monitoring, via a microphone of a user device, a communication of a user. Aspects also include determining an identity of a person communicating with the user based on a voice signature of the person. Aspects further include providing a notification to the user based on a determination that the user has a reminder event for the person.

Abstract: Technical solutions are described for selecting and retrieving, by a media retrieval system, media items for displaying. An example method for selecting and retrieving the media items includes monitoring a conversation of a user via a user device, and extracting a conversation topic from the conversation. The method further includes determining that a metadata database of a media storage associated with the user includes the conversation topic. The method further includes adding, in response, to a topic match database, from the media storage, an identity of a media item matching with the conversation topic, and adding, to a list of media items to be played back by a media display device, the topic match database. Further yet, the method includes playing back, by the media display device, the media item.

Abstract: Methods, systems and computer program products providing traffic light status notifications to drivers are provided. Aspects include determining that a first vehicle, operated by the driver, is approaching a traffic light and receiving, by the first vehicle, traffic light status data from one or more second vehicles in a vicinity of the traffic light via vehicle-to-vehicle communication. Aspects also include obtaining a traffic light pattern for the traffic light from a traffic light pattern database and determining a predicted status of the traffic light at a time when the first vehicle will reach the traffic light based on a speed of the first vehicle, the traffic light status data, and the traffic light pattern. Aspects further include notifying the driver of the predicted status of the traffic light.

Abstract: A computer monitors a plurality of social media communications. The computer identifies a first social media communication of the plurality of social media communications. The computer evaluates the first social media communication for a first communication emergency level. The computer identifies a first location associated with the first social media communication. The computer groups the first social media communication into a location group based, at least in part, on the identified first location. The computer evaluates a location group emergency level, based, at least in part, on the first communication emergency level of the first social media communication. The computer determines the location group emergency level exceeds a threshold value. The computer issues an emergency warning alert in response to determining that the location group emergency level exceeds the threshold value.

Abstract: Technical solutions are described for selecting and retrieving, by a media retrieval system, media items for displaying. An example method for selecting and retrieving the media items includes monitoring a conversation of a user via a user device, and extracting a conversation topic from the conversation. The method further includes determining that a metadata database of a media storage associated with the user includes the conversation topic. The method further includes adding, in response, to a topic match database, from the media storage, an identity of a media item matching with the conversation topic, and adding, to a list of media items to be played back by a media display device, the topic match database. Further yet, the method includes playing back, by the media display device, the media item.

Abstract: The present invention provides a computer implemented method, a system, and a computer program product for verifying a writing of a user. In an exemplary embodiment, the present invention includes in response to receiving a writing on a pressure sensing touchpad logically coupled a computer system, recording a position and a pressure of one or more points of the writing via a pressure sensing touchscreen, executing a set of logical operations normalizing the writing, comparing the normalized writing to one or more stored writing parameters, executing a set of logical operations determining the normalized writing is within a tolerance of writing parameter deviation limits, thereby verifying the writing, and in response to determining the writing is within the tolerance of writing parameter deviation limits, storing, by the computer system, a value indicating that the writing is valid.

Abstract: Methods, systems and computer program products providing traffic light status notifications to drivers are provided. Aspects include determining that a first vehicle, operated by the driver, is approaching a traffic light and receiving, by the first vehicle, traffic light status data from one or more second vehicles in a vicinity of the traffic light via vehicle-to-vehicle communication. Aspects also include obtaining a traffic light pattern for the traffic light from a traffic light pattern database and determining a predicted status of the traffic light at a time when the first vehicle will reach the traffic light based on a speed of the first vehicle, the traffic light status data, and the traffic light pattern. Aspects further include notifying the driver of the predicted status of the traffic light.

Abstract: Aspects of the invention include identifying a user at an electronic device and accessing a profile of the user. The profile includes previously displayed data flagged as causing a negative reaction by the user when displayed to the user. New data for display is received at the electronic device. The new data is analyzed to determine whether it includes at least a subset of the previously displayed data flagged as causing a negative reaction by the user. The new data is displayed on a display of the electronic device based on determining that the new data does not include at least a subset of the previously displayed data flagged as causing a negative reaction. Otherwise, the new data is modified by removing the at least a subset of the previously displayed data from the new data and the modified data is displayed on the display of the electronic device.

Abstract: In one example implementation according to aspects of the present disclosure, a computer-implemented method includes receiving a list of items to be purchased by a user. The method further includes performing an analysis of the list of items based at least in part on a cost for each item of the list of items at each of a plurality of stores, a distance of travel to each of the plurality of stores, and promotional discounts for one or more of the items of the list of items at each of the plurality of stores. The method further includes generating a table of recommendations based on the analysis. Each recommendation of the table of recommendations can include a description, a total travel distance, and a total cost.

Abstract: Methods, systems, and computer program products for providing reminders to users based on voice recognition are provided. Aspects include monitoring, via a microphone of a user device, a communication of a user. Aspects also include determining an identity of a person communicating with the user based on a voice signature of the person. Aspects further include providing a notification to the user based on a determination that the user has a reminder event for the person.