Abstract: Methods for treating B-cell malignancies such as relapsed and/or refractory B-cell malignancies with a population of genetically engineered T cells expressing a chimeric antigen receptor (CAR) targeting CD19 and having multiple genetic edits, including a disrupted TRAC gene, a disrupted ?2M gene, a disrupted Regnase 1 gene, and/or a disrupted TGFBRII gene.

Abstract: Ultrasound imaging is a non-invasive, non-radioactive, and low cost technology for diagnosis and identification of implantable medical devices in real time. Developing new ultrasound activated coatings is important to broaden the utility of in vivo marking by ultrasound imaging. Ultrasound responsive macro-phase segregated micro-composite thin films were developed to be coated on medical devices composed of multiple materials and with multiple shapes and varying surface area. The macro-phase segregated films having silica micro-shells in polycyanoacrylate produces strong color Doppler signals with the use of a standard clinical ultrasound transducer. Electron microscopy showed a macro-phase separation during slow curing of the cyanoacrylate adhesive, as air-filled silica micro-shells were driven to the surface of the film. The air sealed in the hollow space of the silica shells acted as an ultrasound contrast agent and echo decorrelation of air exposed to ultrasound waves produces color Doppler signals.

Abstract: A system can be provided for increasing loudness of an audio signal to present a perceived loudness to a listener that is greater than a loudness provided natively by a loudspeaker. The system can include one or more of the following: a frequency suppressor, a loudness adjuster, an equalizer, and a distortion control module. The frequency suppressor can increase headroom in the audio signal by filtering out low and/or high frequencies. The loudness adjuster can calculate a loudness of the audio signal and apply a gain to the audio signal to increase the loudness. The equalizer can further increase headroom by attenuating portions of a passband of the loudspeaker's frequency response. The distortion control module can induce partial harmonic distortion in the audio signal to further increase loudness.

Abstract: A system can be provided for increasing loudness of an audio signal to present a perceived loudness to a listener that is greater than a loudness provided natively by a loudspeaker. The system can include one or more of the following: a frequency suppressor, a loudness adjuster, an equalizer, and a distortion control module. The frequency suppressor can increase headroom in the audio signal by filtering out low and/or high frequencies. The loudness adjuster can calculate a loudness of the audio signal and apply a gain to the audio signal to increase the loudness. The equalizer can further increase headroom by attenuating portions of a passband of the loudspeaker's frequency response. The distortion control module can induce partial harmonic distortion in the audio signal to further increase loudness.

Abstract: A system can be provided for increasing loudness of an audio signal to present a perceived loudness to a listener that is greater than a loudness provided natively by a loudspeaker. The system can include one or more of the following: a frequency suppressor, a loudness adjuster, an equalizer, and a distortion control module. The frequency suppressor can increase headroom in the audio signal by filtering out low and/or high frequencies. The loudness adjuster can calculate a loudness of the audio signal and apply a gain to the audio signal to increase the loudness. The equalizer can further increase headroom by attenuating portions of a passband of the loudspeaker's frequency response. The distortion control module can induce partial harmonic distortion in the audio signal to further increase loudness.

Abstract: A method for processing audio signals can include receiving left and right front audio signals and left and right rear audio signals, where the left and right rear audio signals. In addition, the method can include applying at least one front perspective filter to each of the left and right front audio signals to yield filtered left and right front output signals, where the left and right front output signals each drive a front speaker. Moreover, the method can include applying at least one rear perspective filter to each of the left and right rear audio signals to yield left and right rear output signals, where the left and right rear output signals each drive a rear speaker to simulate a rear surround sound effect when positioned in front of a listener.

Abstract: A method for processing audio signals can include receiving left and right front audio signals and left and right rear audio signals, where the left and right rear audio signals. In addition, the method can include applying at least one front perspective filter to each of the left and right front audio signals to yield filtered left and right front output signals, where the left and right front output signals each drive a front speaker. Moreover, the method can include applying at least one rear perspective filter to each of the left and right rear audio signals to yield left and right rear output signals, where the left and right rear output signals each drive a rear speaker to simulate a rear surround sound effect when positioned in front of a listener.

Abstract: A system can be provided for increasing loudness of an audio signal to present a perceived loudness to a listener that is greater than a loudness provided natively by a loudspeaker. The system can include one or more of the following: a frequency suppressor, a loudness adjuster, an equalizer, and a distortion control module. The frequency suppressor can increase headroom in the audio signal by filtering out low and/or high frequencies. The loudness adjuster can calculate a loudness of the audio signal and apply a gain to the audio signal to increase the loudness. The equalizer can further increase headroom by attenuating portions of a passband of the loudspeaker's frequency response. The distortion control module can induce partial harmonic distortion in the audio signal to further increase loudness.

Abstract: A system can be provided for increasing loudness of an audio signal to present a perceived loudness to a listener that is greater than a loudness provided natively by a loudspeaker. The system can include one or more of the following: a frequency suppressor, a loudness adjuster, an equalizer, and a distortion control module. The frequency suppressor can increase headroom in the audio signal by filtering out low and/or high frequencies. The loudness adjuster can calculate a loudness of the audio signal and apply a gain to the audio signal to increase the loudness. The equalizer can further increase headroom by attenuating portions of a passband of the loudspeaker's frequency response. The distortion control module can induce partial harmonic distortion in the audio signal to further increase loudness.

Abstract: A method for processing audio signals can include applying at least one front perspective filter to each of left and right front audio signals to yield filtered left and right front output signals, where the left and right front output signals each drive a front speaker. Moreover, the method can include applying at least one rear perspective filter to each of left and right rear audio signals to yield left and right rear output signals, where the left and right rear output signals each drive a rear speaker to simulate a rear surround sound effect when positioned in front of a listener.

Abstract: A method for processing audio signals can include receiving left and right front audio signals, where the left and right front audio signals including information about front spatial position of sound sources relative to a listener. The method can also include receiving left and right rear audio signals, where the left and right rear audio signals include information about rear spatial position of sound sources relative to a listener. In addition, the method can include applying at least one front perspective filter to each of the left and right front audio signals to yield filtered left and right front output signals, where the left and right front output signals each drive a front speaker.

Abstract: A system can be provided for increasing loudness of an audio signal to present a perceived loudness to a listener that is greater than a loudness provided natively by a loudspeaker. The system can include one or more of the following: a frequency suppressor, a loudness adjuster, an equalizer, and a distortion control module. The frequency suppressor can increase headroom in the audio signal by filtering out low and/or high frequencies. The loudness adjuster can calculate a loudness of the audio signal and apply a gain to the audio signal to increase the loudness. The equalizer can further increase headroom by attenuating portions of a passband of the loudspeaker's frequency response. The distortion control module can induce partial harmonic distortion in the audio signal to further increase loudness.