Patents by Inventor Sarala Balachandran

Sarala Balachandran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Insulin-Like Growth Factor-1 Receptor Inhibitors
    Publication number: 20140045832
    Abstract: The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating Insulin-Like-Growth Factor I Receptor and Insulin Receptor. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
    Type: Application
    Filed: April 19, 2012
    Publication date: February 13, 2014
    Applicants: PIRAMAL ENTERPRISES LIMITED, MERCK SHARP & DOHME CORP.
    Inventors: Sarala Balachandran, Christopher J. Dinsmore, Abhijit Roychowdhury, Rajiv Sharma, Ram Asrey Vishwakarma
  • Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors
    Patent number: 8420666
    Abstract: The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: April 16, 2013
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Sonali Rudra, Nidhi Gupta, Lalit Kumar Baregama, Ritu Agarwal, Vinayak Vasantrao Khairnar, Mandadapu Raghu Ramaiah, Venkata P. Palle, Sarala Balachandran, Atul Kondaskar, Manohar Salla, Abhijit Ray, Sunanda G. Dastidar, Lalitha Vijaykrishnan
  • PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS
    Publication number: 20110130403
    Abstract: The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors.
    Type: Application
    Filed: March 13, 2008
    Publication date: June 2, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Sonali Rudra, Nidhi Gupta, Lalit Kumar Baregama, Ritu Agarwal, Mandadapu Raghuramaiah, Vinayak Vasantrao Khairnar, Venkata P. Palle, Sarala Balachandran, Abhijit Ray, Sunada G. Dastidar, Lalitha Vijaykrishnan
  • Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
    Patent number: 7915286
    Abstract: The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type IV selective inhibitors are provided. Prepared compounds correspond to structure XIV Formula (XIV).
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: March 29, 2011
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Venkata P. Palle, Sarala Balachandran, Nidhi Gupta, Vinayak Vasantrao Khairnar, Mandadapu Raghuramaiah, Abhijit Ray, Sunanda Ghose Dastidar
  • INHIBITORS OF PHOSPHODIESTERASE TYPE-IV
    Publication number: 20110021473
    Abstract: The present invention relates to catechol derivatives of formula (I), which can be used as inhibitors of phosphodiesterase (PDPI) type 4 or type 7, Compounds disclosed herein can be useful in the treatment of CNS disorders, inflammatory diseases such as, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type 4 or type 7 inhibitors.
    Type: Application
    Filed: September 22, 2007
    Publication date: January 27, 2011
    Inventors: Sonali Rudra, Nidhi Gupta, Lalit Kumar Baregama, Ritu Agarwal, Vinayak Vasantrao Khairnar, Saswati Chakladar, Mandadapu Raghu Ramaiah, Nagarajan Muthukamal, Sarala Balachandran, Sarika Ramnani, Venkata P. Palle, Sunanda G. Dastidar, Abhijit Ray, Lalitha Vijaykrishan, Jitendra Sattigeri
  • PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS
    Publication number: 20100292196
    Abstract: The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors.
    Type: Application
    Filed: March 14, 2008
    Publication date: November 18, 2010
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Sonali Rudra, Nidhi Gupta, Lalit Kumar Baregama, Ritu Agarwal, Vinayak Vasantrao Khairnar, Mandadapu Raghu Ramaiah, Venkata P. Palle, Sarala Balachandran, Atul Kondaskar, Manohar Salla, Abhijit Ray, Sunanda G. Dastidar, Lalitha Vijaykrishnan
  • Inhibitors of phosphodiesterase type-IV
    Patent number: 7825147
    Abstract: The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.
    Type: Grant
    Filed: August 30, 2004
    Date of Patent: November 2, 2010
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Venkata P. Palle, Sarala Balachandran, Mohammad Salman, Gagan Kukreja, Nidhi Gupta, Abhijit Ray, Sunanda G. Dastidar
  • Substituted indazoles as inhibitors of phosphodiesterase type-IV
    Patent number: 7781460
    Abstract: The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: August 24, 2010
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Venkata Palle, Sarala Balachandran, Lalit Kumar Baregama, Saswati Chakladar, Sarika Ramnani, Nagarajan Muthukamal, Abhijit Ray, Sunanda G. Dastidar
  • PHOSPHODIESTERASE INHIBITORS
    Publication number: 20100029728
    Abstract: The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Compounds disclosed herein can be useful in the treatment of CNS diseases, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and their use as PDE type IV selective inhibitors, are provided.
    Type: Application
    Filed: September 22, 2007
    Publication date: February 4, 2010
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Sarala Balachandran, Nidhi Gupta, Vinayak Vasantrao Khairnar, Sonali Rudra, Venkata P. Palle, Sunanda G. Dastidar
  • SUBSTITUTED PYRAZOLO [3,4-B]PYRIDINES AS PHOSPHODIESTERASE INHIBITORS
    Publication number: 20100022571
    Abstract: The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type IV selective inhibitors are provided. Prepared compounds correspond to structure XIV.
    Type: Application
    Filed: September 18, 2006
    Publication date: January 28, 2010
    Inventors: Venkata P. Palle, Sarala Balachandran, Nidhi Gupta, Vinayak Vasantrao Khairnar, Mandadapu Raghuramaiah, Abhijit Ray, Sunanda Ghose Dastidar
  • SUBSTITUTED PYRAZOLO [3,4-B] PYRIDINES AS PHOSPHODIESTERASE INHIBITORS
    Publication number: 20090306129
    Abstract: The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type IV selective inhibitors are provided. Prepared compounds correspond to structure XIV Formula (XIV).
    Type: Application
    Filed: September 11, 2006
    Publication date: December 10, 2009
    Inventors: Venkata P. Palle, Sarala Balachandran, Nidhi Gupta, Vinayak Vasantrao Khairnar, Mandadapu Raghuramaiah, Abhijit Ray, Sunanda Ghose Dastidar
  • INHIBITORS OF PHOSPHODIESTERASE TYPE-IV
    Publication number: 20090221566
    Abstract: The present invention relates to oxazine derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CMS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors.
    Type: Application
    Filed: October 5, 2006
    Publication date: September 3, 2009
    Inventors: Venkata P. Palle, Sarala Balachandran, Sarika Ramnani, Abhijit Ray, Sunanda G. Dastidar
  • CONDENSED ISOXALINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE TYPE - IV
    Publication number: 20090048247
    Abstract: The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.
    Type: Application
    Filed: February 13, 2006
    Publication date: February 19, 2009
    Inventors: Venkata P. Palle, Sarala Balachandran, Nidhi Gupta, Nagarajan Muthukamal, Mandadapu Raghu Ramaiah, Manoj Kumar Khera, Lailt Kumar Baregama, Vinayak Vasantrao Khairnar, Abhijit Ray, Sunanda G. Dastidar
  • Substituted Indazoles as Inhibitors of Phosphodiesterase Type-Iv
    Publication number: 20080312285
    Abstract: The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors.
    Type: Application
    Filed: August 30, 2006
    Publication date: December 18, 2008
    Inventors: Venkata Palle, Sarala Balachandran, Lalit Kumar Baregama, Saswati Chakladar, Sarika Ramnani, Nagarajan Muthukamal, Abhijit Ray, Sunanda G. Dastidar
  • Phosphodiesterase Inhibitors
    Publication number: 20080280926
    Abstract: The present invention relates to purine derivatives, which can be used as selective phosphodiesterase (PDE) type IV inhibitors. Compounds disclosed herein can be useful in the treatment of asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Also provided are processes for the preparation of disclosed compounds, pharmaceutical composition containing the disclosed compounds and their use as selective phosphodiesterase (PDE) type IV inhibitors.
    Type: Application
    Filed: December 16, 2004
    Publication date: November 13, 2008
    Inventors: Venkata P. Palle, Sarala Balachandran, Mohammad Salman, Gagan Kukreja, Lalit Kumar Baregama, Abhijit Ray, Sunanda Ghosh Dastidar
  • Inhibitors of phosphodiesterase type-IV
    Publication number: 20080009535
    Abstract: The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.
    Type: Application
    Filed: March 27, 2006
    Publication date: January 10, 2008
    Inventors: Sarala Balachandran, Nidhi Gupta, Nagarajan Muthukaman, Vinayak Khairnar, Sarika Ramnani, Lalit Baregama, Saswati Chakladar, Mandadapu Raghu Ramaiah, Ritu Agarwal, Sunanda Dastidar, Abhijit Ray
  • Phosphodiesterase Inhibitors
    Publication number: 20070259874
    Abstract: The present invention relates to isoxazoline derivatives and their analogues, which can be used as phosphodiesterase (PDE) type IV selective inhibitors. Compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases, especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and their use as PDE type IV selective inhibitors, are provided.
    Type: Application
    Filed: November 26, 2004
    Publication date: November 8, 2007
    Inventors: Venkata Palle, Sarala Balachandran, Nidhi Gupta, Gagan Kukreja, Manoj Khera, Lalit Baregama, Raghuramaiah Mandadapu, Abhijit Ray, Sunanda Dastidar
  • Inhibitors of phophodiesterase type-IV
    Publication number: 20050075383
    Abstract: The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.
    Type: Application
    Filed: August 30, 2004
    Publication date: April 7, 2005
    Inventors: Venkata Palle, Sarala Balachandran, Mohammad Salman, Gagan Kukreja, Nidhi Gupta, Abhijit Ray, Sunanda Dastidar