Abstract: A system and method for generating a total health index and recommending an actionable intervention for managing a health risk of a patient is disclosed. The method includes receiving user-generated data, clinical data, and pharmacy data in association with a patient, determining a social health index score based on the user-generated data, determining a clinical risk index score based on the clinical data, determining a medication adherence index score based on the pharmacy data, determining, using a machine learning model on one or more of the social health index score, the clinical risk index score, and the medication adherence index score, a total health index score and an actionable intervention for managing a health risk in association with the patient based on the total health index score, and automatically initiating the actionable intervention.