Patents by Inventor Saraswati V. Sukumar

Saraswati V. Sukumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220364177
    Abstract: In accordance with some embodiments, the present invention comprises use of a rapid and accurate QM-MSP and cMethDNA methylation marker-based assays to quickly distinguish between cancer and benign/normal tissues in a biological sample from a subject suspected of having cancer. Methods for detecting breast, colon, and lung cancers in biological samples of suspect tissues and fluids are also provided to assist in triaging subjects suspected of having cancer for expedited biopsy and pathology review in low resource settings.
    Type: Application
    Filed: June 18, 2020
    Publication date: November 17, 2022
    Inventors: Saraswati V. Sukumar, Mary Jo Fackler, Bradley Downs
  • Patent number: 10316361
    Abstract: To better understand the biology of hormone receptor-positive and negative breast cancer and to identify methylated gene markers of disease progression, a genome-wide methylation array analysis was performed on 103 primary invasive breast cancers and 21 normal breast samples using the Illumina Infinium HumanMethylation27 array that queried 27,578 CpG loci. Forty CpG loci showed differential methylation specific to either ER-positive or ER-negative tumors. Each of the 40 ER-subtype-specific loci was validated in silico using an independent, publicly available methylome dataset from The Cancer Genome Atlas (TCGA). In addition, 100 methylated CpG loci were identified that were significantly associated with disease progression. Arrays containing the ER-subtype-specific loci and their use in methods of diagnosis and treatment of breast cancer are provided.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: June 11, 2019
    Assignee: THE JOHN HOPKINS UNIVERSITY
    Inventors: Saraswati V. Sukumar, Christopher Benedict Umbricht, Antonio C. Wolff, Mary Jo Steele Fackler, Zhe Zhang, Leslie M. Cope, Kala Visvanathan, Peng Huang
  • Publication number: 20140221242
    Abstract: To better understand the biology of hormone receptor-positive and negative breast cancer and to identify methylated gene markers of disease progression, a genome-wide methylation array analysis was performed on 103 primary invasive breast cancers and 21 normal breast samples using the Illumina Infinium HumanMethylation27 array that queried 27,578 CpG loci. Forty CpG loci showed differential methylation specific to either ER-positive or ER-negative tumors. Each of the 40 ER-subtype-specific loci was validated in silico using an independent, publicly available methylome dataset from The Cancer Genome Atlas (TCGA). In addition, 100 methylated CpG loci were identified that were significantly associated with disease progression. Arrays containing the ER-subtype-specific loci and their use in methods of diagnosis and treatment of breast cancer are provided.
    Type: Application
    Filed: July 16, 2012
    Publication date: August 7, 2014
    Applicant: THE JOHN HOPKINS UNIVERSITY
    Inventors: Saraswati V. Sukumar, Christopher Benedict Umbricht, Antonio C. Wolff, Mary Jo Steele Fackler, Zhe Zhang, Leslie M. Cope, Kala Visvanathan, Peng Huang
  • Patent number: 8093013
    Abstract: Methods of diagnosis, prognosis, and treatment of breast cancer, and of metastatic brain cancer, are provided The diagnostic and prognostic methods involve the immunohistochemical detection of the level of expression of the proteins claudin 1, 3, 4, and 7 in tissue or cell samples. Claudins 1 and 7 are underexpressed in the majority of breast cancers, and claudins 3 and 4 are overexpressed. The methods of treatment involve the use of Clostridium perfringens enterotoxin (or a variant thereof) to lyse metastatic cancer cells in the brain and bone that overexpress claudins 3 and 4.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: January 10, 2012
    Assignee: The Johns Hopkins University
    Inventors: Saraswati V. Sukumar, Scott L. Kominsky
  • Publication number: 20090155278
    Abstract: Methods of diagnosis, prognosis, and treatment of breast cancer, and of metastatic brain cancer, are provided The diagnostic and prognostic methods involve the immunohistochemical detection of the level of expression of the proteins claudin 1, 3, 4, and 7 in tissue or cell samples. Claudins 1 and 7 are underexpressed in the majority of breast cancers, and claudins 3 and 4 are overexpressed. The methods of treatment involve the use of Clostridium perfringens enterotoxin (or a variant thereof) to lyse metastatic cancer cells in the brain and bone that overexpress claudins 3 and 4.
    Type: Application
    Filed: March 7, 2008
    Publication date: June 18, 2009
    Inventors: Saraswati V. Sukumar, Scott L. Kominsky
  • Publication number: 20010021701
    Abstract: The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The methods comprise contacting the ductal epithelium of the exocrine gland with an epithelium-destroying gent, preferably by ductal cannulation, so as to realize a prophylactic or therapeutic effect.
    Type: Application
    Filed: December 21, 2000
    Publication date: September 13, 2001
    Inventor: Saraswati V. Sukumar