Patents by Inventor Sarbjot Singh Sokhi

Sarbjot Singh Sokhi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AN IMPROVED PROCESS FOR THE PREPARATION OF SEMAGLUTIDE SIDE CHAIN
    Publication number: 20230295077
    Abstract: The present invention relates to an improved process for the preparation of a compound of Formula (1), The invention also provides improved processes for the preparation of intermediates used in the synthesis of Formula (1). The compound of Formula (1) is used in the synthesis of Semaglutide.
    Type: Application
    Filed: April 9, 2021
    Publication date: September 21, 2023
    Applicant: FRESENIUS KABI ONCOLOGY LIMITED
    Inventors: Maneesh Kumar PANDEY, Sonu Prasad SHUKLA, Sachin NAIN, Sandeep SANDEEP, Sridhar MALE, Sarbjot Singh SOKHI, Govind SINGH, Saswata LAHIRI, Walter CABRI
  • PROCESS FOR THE PREPARATION OF PROPOFOL
    Publication number: 20230174444
    Abstract: The present provides a simple, convenient and time-efficient process for the preparation of propofol. Particularly, the present invention provides an improved process for the preparation of propofol using a heterocyclic base for the decarboxylation reaction. The present invention provides a time-efficient process for the preparation of propofol with high yield and purity.
    Type: Application
    Filed: March 25, 2021
    Publication date: June 8, 2023
    Applicant: FRESENIUS KABI ONCOLOGY LTD.
    Inventors: Ashwani Kumar SHARMA, Manish PANDEY, Abhishek GIRI, Sarbjot Singh SOKHI, Govind SINGH, Saswata LAHIRI, Walter CABRI
  • Process for the preparation of boronic acid esters
    Patent number: 11667654
    Abstract: The present invention relates to an improved process for the preparation of a compound of formula (I), wherein PG1 may be independently selected from tert-butyloxycarbonyl (Boc), phthaloyl, 9-fluorenylmethyloxycarbonyl (Fmoc), triphenylmethyl (Trityl), carboxybenzyl (Cbz), trifluoroacetyl, benzyl (Bn), benzylidene, methanesulfonyl (Mesyl), toluene sulfonyl (Tosyl) or acyl; its isolation as solid and use for the preparation of the compound of formula (IV), in particular the compound of formula (IV) i.e. [(1R)-3-methyl-1[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl) amino]propyl]amino]butyl] boronic acid with more than 99.95% chiral purity, as measured by HPLC.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: June 6, 2023
    Assignee: Fresenius Kabi Oncology Ltd.
    Inventors: Maneesh Kumar Pandey, Raj Narayan Tiwari, Sonu Shukla, Sarbjot Singh Sokhi, Govind Singh, Saswata Lahiri, Walter Cabri
  • Process for the preparation of ribociclib and its salts
    Patent number: 11440912
    Abstract: The invention relates to a process for the preparation of ribociclib of formula V or its salts. The invention provides novel crystalline forms of ribociclib succinate and ribociclib trifluoroacetate. The present invention also relates to pharmaceutical compositions comprising a crystalline form of ribociclib succinate and at least a pharmaceutically acceptable carrier. It further relates to the use of such compositions in the treatment of cancer.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: September 13, 2022
    Assignee: FRESENIUS KABI ONCOLOGY LTD
    Inventors: Sarbjot Singh Sokhi, Govind Singh, Saswata Lahiri, Maneesh Kumar Pandey, Raj Narayan Tiwari, Sonu Shukla, Sachin Musmade, Heena Dua, Walter Cabri
  • Process for purification of carfilzomib intermediate
    Patent number: 11078231
    Abstract: The present invention relates to a process for the purification of compound of formula II, wherein X may be independently selected from trifluoroacetic acid, hydrochloric acid, hydrobromic acid, p-toluene sulfonic acid and phosphoric acid; its isolation as solid and use for the preparation of carfilzomib.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: August 3, 2021
    Assignee: FRESENIUS KABI ONCOLOGY LTD
    Inventors: Walter Cabri, Saswata Lahiri, Govind Singh, Sarbjot Singh Sokhi, Maneesh Kumar Pandey, Raj Narayan Tiwari, Sonu Prasad Shukla
  • AN IMPROVED PROCESS FOR THE PREPARATION OF RIBOCICLIB AND ITS SALTS
    Publication number: 20200277295
    Abstract: The invention relates to a process for the preparation of ribociclib of formula V or its salts. The invention provides novel crystalline forms of ribociclib succinate and ribociclib trifluoroacetate. The present invention also relates to pharmaceutical compositions comprising a crystalline form of ribociclib succinate and at least a pharmaceutically acceptable carrier. It further relates to the use of such compositions in the treatment of cancer.
    Type: Application
    Filed: October 26, 2018
    Publication date: September 3, 2020
    Applicant: FRESENIUS KABI ONCOLOGY LIMITED
    Inventors: Sarbjot Singh SOKHI, Govind SINGH, Saswata LAHIRI, Maneesh Kumar PANDEY, Raj Narayan TIWARI, Sonu SHUKLA, Sachin MUSMADE, Heena DUA, Walter CABRI
  • AN IMPROVED PROCESS FOR THE PREPARATION OF BORONIC ACID ESTERS
    Publication number: 20200031850
    Abstract: The present invention relates to an improved process for the preparation of a compound of formula (I), wherein PG1 may be independently selected from tert-butyloxycarbonyl (Boc), phthaloyl, 9-fluorenylmethyloxycarbonyl (Fmoc), triphenylmethyl (Trityl), carboxybenzyl (Cbz), trifluoroacetyl, benzyl (Bn), benzylidene, methanesulfonyl (Mesyl), toluene sulfonyl (Tosyl) or acyl; its isolation as solid and use for the preparation of the compound of formula (IV), in particular the compound of formula (IV) i.e. [(1R)-3-methyl-1[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl) amino]propyl]amino]butyl] boronic acid with more than 99.95% chiral purity, as measured by HPLC.
    Type: Application
    Filed: February 19, 2018
    Publication date: January 30, 2020
    Applicant: FRESENIUS KABI ONCOLOGY LIMITED
    Inventors: Maneesh Kumar PANDEY, Raj Narayan TIWARI, Sonu SHUKLA, Sarbjot Singh SOKHI, Govind SINGH, Saswata LAHIRI, Walter CABRI
  • A PROCESS FOR PURIFICATION OF CARFILZOMIB INTERMEDIATE
    Publication number: 20190218249
    Abstract: The present invention relates to a process for the purification of compound of formula II, wherein X may be independently selected from trifluoroacetic acid, hydrochloric acid, hydrobromic acid, p-toluene sulfonic acid and phosphoric acid; its isolation as solid and use for the preparation of carfilzomib.
    Type: Application
    Filed: September 13, 2017
    Publication date: July 18, 2019
    Applicant: FRESENIUS KABI ONCOLOGY LIMITED
    Inventors: Walter CABRI, Saswata LAHIRI, Govind SINGH, Sarbjot Singh SOKHI, Maneesh Kumar PANDEY, Raj Narayan TIWARI, Sonu Prasad SHUKLA
  • Process for purification of Carfilzomib
    Patent number: 10253066
    Abstract: The present invention relates to a process for the purification of Carfilzomib of Formula I that reduces the level of an acetamide impurity of Formula II preferably below 0.10 wt %.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: April 9, 2019
    Assignee: FRESENIUS KABI ONCOLOGY LIMITED
    Inventors: Maneesh Kumar Pandey, Raj Narayan Tiwari, Sarbjot Singh Sokhi, Govind Singh, Saswata Lahiri, Walter Cabri
  • A PROCESS FOR PURIFICATION OF CARFILZOMIB
    Publication number: 20180002377
    Abstract: The present invention relates to a process for the purification of Carfiizomib of Formula I that reduces the level of an acetamide impurity of Formula II preferably below 0.10 wt %. Formula I Formula II.
    Type: Application
    Filed: December 1, 2015
    Publication date: January 4, 2018
    Inventors: Maneesh Kumar Pandey, Raj Narayan Tiwari, Sarbjot Singh Sokhi, Govind Singh, Saswata Lahiri, Walter Cabri
  • Process for the preparation of febuxostat
    Patent number: 8916713
    Abstract: An improved and efficient process for the preparation of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (febuxostat) that is substantially free from amide by-product is provided.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: December 23, 2014
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Pranab Chatterjee, Asok Nath, Sarbjot Singh Sokhi, Mohan Prasad
  • PROCESS FOR THE PREPARATION OF FEBUXOSTAT
    Publication number: 20130245278
    Abstract: An improved and efficient process for the preparation of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (febuxostat) that is substantially free from amide by-product is provided.
    Type: Application
    Filed: July 15, 2011
    Publication date: September 19, 2013
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Pranab Chatterjee, Asok Nath, Sarbjot Singh Sokhi, Mohan Prasad