Patents by Inventor Sarka POKORNA

Sarka POKORNA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VARIANTS OF BETA-GLUCOCEREBROSIDASE FOR USE IN TREATING GAUCHER DISEASE
    Publication number: 20230132790
    Abstract: A genetically modified human beta-glucocerebrosidase (GCase) is disclosed. The genetically modified GCase comprising an amino acid sequence at least 85% identical to SEQ ID NO: 2; and comprising mutations at coordinates L34P, K224N/G, T369E and N370D, where the coordinates correspond to said SEQ ID NO: 2; and capable of catalyzing hydrolysis of a glycolipid glucosylceramide (GlcCer). Pharmaceutical compositions comprising the genetically modified GCase and therapeutic methods of using same are also disclosed.
    Type: Application
    Filed: March 29, 2021
    Publication date: May 4, 2023
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Anthony H. FUTERMAN, Israel SILMAN, Joel L. SUSSMAN, Sarel FLEISHMAN, Adi GOLDENZWEIG, Sarka POKORNA, Yaacov ASHANI, Olga KHERSONSKY